論文

査読有り
2015年10月

The inhibitory effect of locally injected dexmedetomidine on carrageenan-induced nociception in rats

EUROPEAN JOURNAL OF PHARMACOLOGY
  • Yuka Honda
  • ,
  • Hitoshi Higuchi
  • ,
  • Yoshikazu Matsuoka
  • ,
  • Akiko Yabuki-Kawase
  • ,
  • Minako Ishii-Maruhama
  • ,
  • Yumiko Tomoyasu
  • ,
  • Shigeru Maeda
  • ,
  • Hiroshi Morimatsu
  • ,
  • Takuya Miyawaki

764
開始ページ
215
終了ページ
219
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.ejphar.2015.06.054
出版者・発行元
ELSEVIER SCIENCE BV

Recent studies showed that the administration of dexmedetomidine relieved hyperalgesia in the presence of neuropathic pain. These findings have led to the hypothesis that the local administration of dexmedetomidine is useful for relieving acute inflammatory nociception, such as postoperative pain. Thus, we evaluated the inhibitory effect of locally injected dexmedetomidine on acute inflammatory nociception. Acute inflammatory nociception was induced by an intraplantar injection of 1% carrageenan into the hindpaws of rats, and dexmedetomidine was also injected combined with carrageenan. The paw withdrawal threshold based on von Frey filament stimulation was measured until 12 h after injection. We compared the area under the Lime-curve (AUC) between carrageenan and carrageenan with dexmedetomidine. To clarify that the action of dexmedetomidine was via alpha(2)-adrenoceptors, we evaluated the effect of yohimbine, a selective antagonist of alpha(2)-adrenoceptors, on the anti-nociception of dexmedetomidine. As the results, the intraplantar injection of carrageenan with over 10 mu M dexmedetomidine significantly increased AUC, compared to that with only carrageenan injection. This effect of dexmedetomidine was reversed by the addition of yohimbine to carrageenan and dexmedetomidine. These results demonstrated that the locally injected dexmedetomidine was effective against carrageenan-induced inflammatory nociception via alpha(2)-adrenoceptors. The findings suggest that the local injection of dexmedetomidine is useful for relieving local acute inflammatory nociception. (C) 2015 Elsevier B.V. All rights reserved,

Web of Science ® 被引用回数 : 5

リンク情報
DOI
https://doi.org/10.1016/j.ejphar.2015.06.054
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26160316
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000362987800027&DestApp=WOS_CPL

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