論文

査読有り
2014年12月1日

Hemodynamic changes by drug interaction of adrenaline with chlorpromazine

Anesthesia Progress
  • Hitoshi Higuchi
  • ,
  • Akiko Yabuki
  • ,
  • Minako Ishii-Maruhama
  • ,
  • Yumiko Tomoyasu
  • ,
  • Shigeru Maeda
  • ,
  • Takuya Miyawaki

61
4
開始ページ
150
終了ページ
154
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2344/0003-3006-61.4.150
出版者・発行元
Allen Press Inc.

Adrenaline (epinephrine) is included in dental local anesthesia for the purpose of vasoconstriction. In Japan, adrenaline is contraindicated for use in patients receiving antipsychotic therapy, because the combination of adrenaline and an antipsychotic is considered to cause severe hypotension
however, there is insufficient evidence supporting this claim. The purpose of the present study was to clarify the changes in hemodynamics caused by drug interaction between adrenaline and an antipsychotic and to evaluate the safety of the combined use of adrenaline and an antipsychotic in an animal study. Male Sprague-Dawley rats were anesthetized with sodium pentobarbital. A catheter was inserted into the femoral artery to measure blood pressure and pulse rate. Rats were pretreated by intraperitoneal injection of chlorpromazine or chlorpromazine and propranolol, and after 20 minutes, saline or 1 of 3 different doses of adrenaline was administered by intraperitoneal injection. Changes in the ratio of mean arterial blood pressure and pulse rate were measured after the injection of adrenaline. Significant hypotension and tachycardia were observed after the injection of adrenaline in the chlorpromazine-pretreated rats. These effects were in a dose-dependent manner, and 100 μg/kg adrenaline induced significant hemodynamic changes. Furthermore, in the chlorpromazine and propranolol-pretreated rats, modest hypertension was induced by adrenaline, but hypotension and tachycardia were not significantly shown. Hypotension was caused by a drug interaction between adrenaline and chlorpromazine through the activation of the β-adrenergic receptor and showed a dose-dependent effect. Low-dose adrenaline similar to what might be used in human dental treatment did not result in a significant homodynamic change.

リンク情報
DOI
https://doi.org/10.2344/0003-3006-61.4.150
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25517550

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