The release of histamine induced by C. albicans was significantly higher in asthmatics aged 21-30 yr, 41-50 yr and 61+ years old compared with the age-matched groups of healthy subjects. The level of C. albicans specific IgG was significantly higher in asthmatics aged 41-50 years old compared with age-matched group of healthy subjects. No significant difference was found among any age groups of healthy and asthmatic subjects. The increased level of C. albicans specific IgG seemed not to be of significance in the pathogenesis of asthma.