論文

国際誌
2020年

Short-term and long-term comparisons of laparoscopy-assisted proximal gastrectomy with esophagogastrostomy by the double-flap technique and laparoscopy-assisted total gastrectomy for proximal gastric cancer.

PloS one
  • Tomoko Tsumura
  • Shinji Kuroda
  • Masahiko Nishizaki
  • Satoru Kikuchi
  • Yoshihiko Kakiuchi
  • Nobuo Takata
  • Atene Ito
  • Megumi Watanabe
  • Kazuya Kuwada
  • Shunsuke Kagawa
  • Toshiyoshi Fujiwara
  • 全て表示

15
11
開始ページ
e0242223
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0242223

BACKGROUND: Although proximal gastrectomy (PG) is a recognized surgical procedure for early proximal gastric cancer, total gastrectomy (TG) is sometimes selected due to concern about severe gastroesophageal reflux. Esophagogastrostomy by the double-flap technique (DFT) is an anti-reflux reconstruction after PG, and its short-term effectiveness has been reported. However, little is known about the long-term effects on nutritional status and quality of life (QOL). METHODS: Gastric cancer patients who underwent laparoscopy-assisted PG (LAPG) with DFT or laparoscopy-assisted TG (LATG) between April 2011 and March 2014 were retrospectively analyzed. Body weight (BW), body mass index (BMI), and prognostic nutritional index (PNI) were reviewed to assess nutritional status, and the Postgastrectomy Syndrome Assessment Scale (PGSAS)-45 was used to assess QOL. RESULTS: A total of 36 patients (LATG: 17, LAPG: 19) were enrolled. Four of 17 LATG patients (24%) were diagnosed with Stage ≥II after surgery, and half received S-1 adjuvant chemotherapy. BW and PNI were better maintained in LAPG than in LATG patients until 1-year follow-up. Seven of 16 LATG patients (44%) were categorized as "underweight (BMI<18.5 kg/m2)" at 1-year follow-up, compared to three of 18 LAPG patients (17%; p = 0.0836). The PGSAS-45 showed no significant difference in all QOL categories except for decreased BW (p = 0.0132). Multivariate analysis showed that LATG was the only potential risk factor for severe BW loss (odds ratio: 3.03, p = 0.0722). CONCLUSIONS: LAPG with DFT was superior to LATG in postoperative nutritional maintenance, and can be the first option for early proximal gastric cancer.

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0242223
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33180871
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660475
ID情報
  • DOI : 10.1371/journal.pone.0242223
  • PubMed ID : 33180871
  • PubMed Central 記事ID : PMC7660475

エクスポート
BibTeX RIS