2020年3月10日
Auditory steady-state response at 20Hz and 40Hz in young typically developing children and children with autism spectrum disorder.
Psychiatry and clinical neurosciences
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- 巻
- 74
- 号
- 6
- 開始ページ
- 354
- 終了ページ
- 361
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/pcn.12998
AIM: The early detection of autistic tendencies in children is essential for providing proper care and education. The auditory steady- state response (ASSR) provides a passive, non-invasive technique for assessing neural synchrony at specific response frequencies in many mental disorders, including autism spectrum disorder (ASD), but few studies have investigated its use in young children. This study investigated the ASSR to 20 and 40 Hz in typically developing (TD) children and children with ASD aged 5-7 years. METHODS: The participants were 23 children with ASD and 32 TD children aged 5-7 years. Using a custom-made magnetoencephalography, we measured ASSR at 20 and 40 Hz, compared the results between the groups, and evaluated the association with intellectual function as measured by Kaufmann Assessment Battery for Children (K-ABC). RESULTS: Responses to 20 and 40 Hz were clearly detected in both groups with no significant difference identified. Consistent with previous findings, right dominance of the 40 Hz ASSR was observed in both groups. In the TD children, the right- side 40 -Hz ASSR was correlated with age. K-ABC score was correlated with the left-side 40-Hz ASSR in both groups. CONCLUSIONS: Right-dominant ASSR was successfully detected in young children in young TD children and children with ASD. No difference in ASSR was observed between the children with ASD and the TD children, although the right-side 40-Hz ASSR increased with age only in the TD children. Left-side 40-Hz ASSR was associated with intelligence score in both groups. This article is protected by copyright. All rights reserved.
- ID情報
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- DOI : 10.1111/pcn.12998
- PubMed ID : 32155301