Cellular Physiology and Biochemistry Vol.47(No.5) 1936-1950 Jul 2018 [Refereed]
In this study, we demonstrated that neutrophil differentiation is regulated by ER stress/UPR that is supported by mitochondrial ATP supply, in which IRE1-XBP1 activation is essential. Our findings provide the evidence that mitochondrial energy met...
Journal of Bioscience and Bioengineering Vol.Volume 125(No.Issue 4) 365-496 Apr 2018 [Refereed]
The conventional two-dimensional (2D) in vitro culture system is frequently used to analyze the gene expression with or without extracellular signals. However, the cells derived from primary culture and cell lines frequently deviate the gene expre...
Biochemical and Biophysical Research Communications Vol.497(No.2) 719-725 Feb 2018 [Refereed]
AK2 is an adenylate phosphotransferase that localizes at the intermembrane spaces of the mitochondria, and its mutations cause a severe combined immunodeficiency with neutrophil maturation arrest named reticular dysgenesis (RD). Although the dysfu...
Journal of Experimental & Clinical Cancer Research Vol.35(No.1) 48-48 Mar 2016 [Refereed]
Background: Adenylate kinase is a key enzyme in the high-energy phosphoryl transfer reaction in living cells. Anisoform of this enzyme, adenylate kinase 4 (AK4), is localized in the mitochondrial matrix and is believed to beinvolved in stress, dru...
Oral Diseases Vol.22(No.2) 132-139 Jan 2016 [Refereed]
OBJECTIVE:Disruption of the third zinc finger domain of specificity protein 6 (SP6) presents an enamel-specific defect in a rat model of amelogenesis imperfecta (AMI rats). To understand the molecular basis of amelogenesis imperfecta caused by the...
Miyoshi K, Horiguchi T, Tanimura A, Hagita H, Noma T
BioMed research international 2015 121575-121575 Aug 2015 [Refereed]
Oral mucosa is a useful material for regeneration therapy with the advantages of its accessibility and versatility regardless of age and gender. However, little is known about the molecular characteristics of oral mucosa. Here we report the first ...
Stem cells international 2015 165867-165867 Jun 2015 [Refereed]
Stem cell therapy appears to be promising for restoring damaged or irreparable lung tissue. However, establishing a simple and reproducible protocol for preparing lung progenitor populations is difficult because the molecular basis for alveolar ep...
Higashi K, Hazama S, Araki A, Yoshimura K, Iizuka N, Yoshino S, Noma T, Oka M
International journal of oncology 45(4) 1412-1420 Oct 2014 [Refereed]
A therapeutic vaccine against minimal residual cancer cells is needed for the treatment of patients with colorectal cancer. Several gene therapy studies have revealed that the combination of a suicide gene and cytokine gene might induce effective ...
Yanuaryska RD, Miyoshi K, Adiningrat A, Horiguchi T, Tanimura A, Hagita H, Noma T
The journal of medical investigation : JMI 61(3-4) 306-317 Aug 2014 [Refereed]
Sp6 is a transcription factor of the SP/KLF family and an indispensable regulator of the morphological dynamics of ameloblast differentiation during tooth development. However, the underlying molecular mechanisms remain unclear. We have previously...
Tanimura A, Horiguchi T, Miyoshi K, Hagita H, Noma T
PloS one 9(2) e89916-e89916 Feb 2014 [Refereed]
Adenine nucleotide dynamics in the mitochondrial intermembrane space (IMS) play a key role in oxidative phosphorylation. In a previous study, Drosophila adenylate kinase isozyme 2 (Dak2) knockout was reported to cause developmental lethality at th...
