NOMA Takafumi

J-GLOBAL         Last updated: Dec 26, 2018 at 08:39
NOMA Takafumi
The University of Tokushima
Institute of Health Biosciences The University of Tokushima Graduate School, Department of Molecular Biology
Job title
Medical Doctor(Kyoto University)

Research Areas


Awards & Honors

Jan 2004
Analysis for structure and function of adenylate kinase isozymes, 康楽賞, The Koraku Foundation
Winner: Takafumi Noma

Published Papers

Ayako Tanimura, Keiko Miyoshi, Taigo Horiguchi, Hiroko Hagita, Koichi Fujisawa, Takafumi Noma
Cellular Physiology and Biochemistry   Vol.47(No.5) 1936-1950   Jul 2018   [Refereed]
In this study, we demonstrated that neutrophil differentiation is regulated by ER stress/UPR that is supported by mitochondrial ATP supply, in which IRE1-XBP1 activation is essential. Our findings provide the evidence that mitochondrial energy met...
Yosi Dian Arinawati, Keiko Miyoshi, Ayako Tanimura, Taigo Horiguchi, Hiroko Hagita, Takafumi Noma
Journal of Bioscience and Bioengineering   Vol.Volume 125(No.Issue 4) 365-496   Apr 2018   [Refereed]
The conventional two-dimensional (2D) in vitro culture system is frequently used to analyze the gene expression with or without extracellular signals. However, the cells derived from primary culture and cell lines frequently deviate the gene expre...
Koichi Oshima, Norikazu Saiki, Michihiro Tanaka, Hiromi Imamura, Akira Niwa, Ayako Tanimura, Ayako Nagahashi, Akiyoshi Hirayama, Keisuke Okita, Akitsu Hotta, Shuichi Kitayama, Mitsujiro Osawa, Shin Kaneko, Akira Watanabe, Isao Asaka, Wataru Fujibuchi, Kohsuke Imai, Hiromasa Yabe, Yoshiro Kamachi, Junichi Hara, Seiji Kojima, Masaru Tomita, Tomoyoshi Soga, Takafumi Noma, Shigeaki Nonoyama, Tatsutoshi Nakahata, K Megumu Saito
Biochemical and Biophysical Research Communications   Vol.497(No.2) 719-725   Feb 2018   [Refereed]
AK2 is an adenylate phosphotransferase that localizes at the intermembrane spaces of the mitochondria, and its mutations cause a severe combined immunodeficiency with neutrophil maturation arrest named reticular dysgenesis (RD). Although the dysfu...
Fujisawa Koichi, Terai Shuji, Takami Taro, Yamamoto Naoki, Yamasaki Takahiro, Matsumoto Toshihiko, Yamaguch Kazuhito, Owada Yuji, Nishina Hiroshi, Takafumi Noma, Sakaida Isao
Journal of Experimental & Clinical Cancer Research   Vol.35(No.1) 48-48   Mar 2016   [Refereed]
Background: Adenylate kinase is a key enzyme in the high-energy phosphoryl transfer reaction in living cells. Anisoform of this enzyme, adenylate kinase 4 (AK4), is localized in the mitochondrial matrix and is believed to beinvolved in stress, dru...
A Adiningrat, Ayako Tanimura, Keiko Miyoshi, Hiroko Hagita, RD Yanuaryska, Arinawati Yosi Dian, Taigo Horiguchi, Takafumi Noma
Oral Diseases   Vol.22(No.2) 132-139   Jan 2016   [Refereed]
OBJECTIVE:Disruption of the third zinc finger domain of specificity protein 6 (SP6) presents an enamel-specific defect in a rat model of amelogenesis imperfecta (AMI rats). To understand the molecular basis of amelogenesis imperfecta caused by the...
Miyoshi K, Horiguchi T, Tanimura A, Hagita H, Noma T
BioMed research international   2015 121575-121575   Aug 2015   [Refereed]
Oral mucosa is a useful material for regeneration therapy with the advantages of its accessibility and versatility regardless of age and gender. However, little is known about the molecular characteristics of oral mucosa. Here we report the first ...
Kondo H, Miyoshi K, Sakiyama S, Tangoku A, Noma T
Stem cells international   2015 165867-165867   Jun 2015   [Refereed]
Stem cell therapy appears to be promising for restoring damaged or irreparable lung tissue. However, establishing a simple and reproducible protocol for preparing lung progenitor populations is difficult because the molecular basis for alveolar ep...
Higashi K, Hazama S, Araki A, Yoshimura K, Iizuka N, Yoshino S, Noma T, Oka M
International journal of oncology   45(4) 1412-1420   Oct 2014   [Refereed]
A therapeutic vaccine against minimal residual cancer cells is needed for the treatment of patients with colorectal cancer. Several gene therapy studies have revealed that the combination of a suicide gene and cytokine gene might induce effective ...
Yanuaryska RD, Miyoshi K, Adiningrat A, Horiguchi T, Tanimura A, Hagita H, Noma T
The journal of medical investigation : JMI   61(3-4) 306-317   Aug 2014   [Refereed]
Sp6 is a transcription factor of the SP/KLF family and an indispensable regulator of the morphological dynamics of ameloblast differentiation during tooth development. However, the underlying molecular mechanisms remain unclear. We have previously...
Tanimura A, Horiguchi T, Miyoshi K, Hagita H, Noma T
PloS one   9(2) e89916-e89916   Feb 2014   [Refereed]
Adenine nucleotide dynamics in the mitochondrial intermembrane space (IMS) play a key role in oxidative phosphorylation. In a previous study, Drosophila adenylate kinase isozyme 2 (Dak2) knockout was reported to cause developmental lethality at th...


Tetsuo Ichikawa, Takafumi Noma, Keiko Miyoshi, Keisuke Nishigawa, Noriko Mizusawa, Miwa Matsuyama, Hiroshi Yoshimura, Maki Hosoki
連携機能を活用した口腔からQOL向上を目指す研究報告書   1-67   2012
Takafumi Noma, 他
キャンパスライフ      Mar 2006
Takafumi Noma, 他
キャンパスライフ      Mar 2005
Takafumi Noma
大学教育ジャーナル   Vol.1(No.1) 65-68   Mar 2004
Takafumi Noma
広報   Vol.10 51-54   Dec 2003

Conference Activities & Talks

Takafumi Noma
広島女学院大学 管理栄養学会 秋季講演会   31 Oct 2018   
Possible roles of Sp6 in ameloblast differentiation
Keiko Miyoshi, Arinawati Yosi Dian, Hagita Hiroko, Taigo Horiguchi, Takafumi Noma
The 6th International Conference on Biology and Pathobiology of KLF/Sp Transcription Factors   29 Oct 2018   
Perturbation of gene regulateion in an in vitro amelogenesis imperfecta model
Arinawati Yosi Dian, Keiko Miyoshi, Hiroko Hagita, Taigo Horiguchi, Takafumi Noma
The 91st Annual Meeting of the Japanese Biochemical Society   24 Sep 2018   
Arinawati Yosi Dian, Keiko Miyoshi, Taigo Horiguchi, Takafumi Noma
第60回歯科基礎医学会学術大会   6 Sep 2018   
Demonstration of defective amelogenesis using an in vitro amelogenesis imperfecta model
Arinawati Yosi Dian, Keiko Miyoshi, Hagita Hiroko, Taigo Horiguchi, Takafumi Noma
第257回徳島医学会学術集会   5 Aug 2018   


Identification of novel regulator in mitochondrial metabolism

Research Grants & Projects

Grants-in-Aid for Scientific Research
Project Year: Apr 2015 - Mar 2018    Investigator(s): 三好 圭子
Grants-in-Aid for Scientific Research
Project Year: Apr 2015 - Mar 2018    Investigator(s): 野間 隆文
Grants-in-Aid for Scientific Research
Project Year: Apr 2012 - Mar 2015    Investigator(s): MIYOSHI Keiko
Grants-in-Aid for Scientific Research
Project Year: Apr 2011 - Mar 2014    Investigator(s): NOMA Takafumi
Grants-in-Aid for Scientific Research
Project Year: Apr 2005 - Mar 2006    Investigator(s): 松尾 敬志