Hirokazu IIDA

J-GLOBAL         Last updated: Jun 17, 2019 at 11:18
Hirokazu IIDA
Kanto Gakuin University
College of Engineering Department of Applied Material and Life Science
Job title
Associate Professor
Ph. D.(Kyoto University)

Research Areas


Academic & Professional Experience

Apr 2018
Graduate School of of Technology, Kanto Gakun University
Apr 2013
Asssociate Professor, College of Science and Engineering, Kanto Gakun University
Apr 2011
Mar 2013
Asssociate Professor, Department of Engineering, Kanto Gakun University
Apr 2004
Sep 2010
Lecturer, Faculty of Pharmacy, Chiba Institute of Science
Aug 2001
Mar 2004
Assistant Professor, Faculty of Dentistry, The University of Tokushima
Jan 2001
Jul 2001
part-time lecturer, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
Apr 1999
Dec 2000
Postdoctoral Fellow, CREST, Japan Science and Technology
Jun 1996
Mar 1999
Postdoctoral fellow, Department of Chemistry, University of Alberta


Apr 1993
Mar 1996
Doctor of Human and Environmental Sciences, Graduate School of Human and Environmental Sciences, Kyoto University
Apr 1991
Mar 1993
Master of Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University
Apr 1987
Mar 1991
Department of Pharmaceutical Sciences, Tohoku University

Published Papers

Accurate Structure Determination of Saccharides by the use of coupling constant 1JCH on NMR
H. Iida, K. Takahashi
J. Tech. Res.   62 1-9   Mar 2019   [Refereed]
There are 8 kinds of isomers such as glucose and mannose in 6-carbon saccharide, aldohexose. These isomers depend on differences in the configuration of hydroxy groups and hydrogens at the 2-, 3- and 4-position carbons. For each sugar such as gluc...
Iida, H.; Takahashi, K.; Akatsu, Y.; Mizukami, K
Current Microwave Chemistry   4(2) 108-114   Apr 2017   [Refereed]
A highly efficient and rapid method for Michael addn. between phenols and acrylonitrile, aniline and acrylonitrile, phenol and Me acrylate, and anilines and Me acrylate was described. 4-Dimethylaminopyridine was added to a mixt. of phenol and acry...
English Lecture Meetings on Science Topics as a Way of Motivating Science-Major Students to Study English as a Foreign Language (EFL): A Report on a Collaborative ESP (English for Specific Purposes) Project by Content Teachers (Experts of Science) and Lan
K. Kobayashi, Y. Kitamura, H. Mino, H. Iida, H. Uehara, and K. Takahashi
Journal of Science and Humanities   46 13-41   Mar 2017   [Refereed]
Iida, H.; Takahashi, K.
PIERS 2016   2016 4198-4201   Sep 2016   [Refereed]
Iida, H.; Akatsu, Y.; Mizukami, K.; Natori, S.; Matsukawa, M.; Takahashi, K.
Synth. Commun.   46(7) 581-585   May 2016   [Refereed]
The addn. of phenols RC6H4OH (R = H, 2-CH3, 4-Cl, etc.) to acrylonitrile in the presence of aq. benzyltrimethylammonium hydroxide or tetramethylammonium hydroxide under microwave irradn. yielded the corresponding Michael adducts RC6H4O(CH2)2CN. Th...
Exact Assignment of 13C NMR of Pyrrole-Imidazole Polyamides using HMBC (2)
H. Iida, K. Otaka, T. Inoue, K. Segawa, K. Baba, and K. Kurisu
J. Tech. Res.   59 93-99   Mar 2016   [Refereed]
Synthesis of 4-phenylbutanoic acid analogues possessing heteroaromatic unit as chemical chaperones for prevention against endoplasmic reticulum stress
H. Iida and M. Abe
J. Tech. Res.   58 43-48   Mar 2015   [Refereed]
Exact assignment of 13C NMR of pyrrole-imidazole polyamides using HMBC (1)
H. Iida, K. Otaka, and T. Inoue
J. Tech. Res.   58 49-55   Mar 2015   [Refereed]
Microwave Assisted Amide Bond Formation toward the Synthesis of DNA binding agent Pyrrole-Imidazole Polyamide
H. Iida, Y. Fujimori, T. Inoue, and K. Otaka
Bull. Inst. Sci. Tech, Kanto Gakuin Univ.   43 3-9   Mar 2015   [Refereed]
H. Iida, M. Suda, E. Nakajima, H. Hakamatsuka, Y. Nagashima, K. Joho, K. Amemiya, T. Moromizato, K. Matsumoto, Y. Murakami, and H. Hamana
Heterocycles   81(9) 2057-2062   2010   [Refereed]
K. Matsumoto, K. Joho, S. Mimori, H. Iida, H. Hamana, and A. Kakehi
Heterocycles   76(2) 1061-1067   2008   [Refereed]
M. Fujimoto, H. Iida, T. Homma, I. Kimura, M. Mori, and H. Hamana
Biol. Pharm. Bull.   31(9) 1813-1815   2008   [Refereed]
Is there any effect of pressure on metal cation extraction properties of 7,13-bis(2-‘-thiazolyl)-1,4,10-trioxa-7,13-diazacyclopentadecane?
K. Matsumoto, M. Toda, H. Iida, and H. Hamana
Heterocyclic Commun   13(1) 13-16   2007   [Refereed]
K. Matsumoto, Y. Ikemi, M. Suda, H. Iida, and H. Hamana
Heterocycles   72 187-190   2007   [Refereed]
K. Matsumoto, H. Iida, S. Mimori, H. Hamana, and T. Uchida
Heterocycles   73 883-889   2007   [Refereed]
H. Iida, T. Moromizato, H. Hamana, and K. Matsumoto
Synth. Commun.   48(11) 2037-2039   2007   [Refereed]
H. Iida, H. Hamana and K. Matsumoto
Synth. Commun.   37 1801-1805   2007   [Refereed]
K. Matsumoto, H. Iida, S. Mimori, H. Hamana, T. Uchida, and A. Kahehi
Heterocycles   74 1019-1025   2007   [Refereed]
X-Ray Structures and Molecular Orbital Calculations of 6-Phosphapentacyclo[,4.03,7.05,10]- dodecane 6-Oxides
K. Matsumoto, M. Toda, H. Iida, H. Hamana, and A. Kahehi
Heterocyclic Commun   13(4) 199-202   2007   [Refereed]
Magnetic non-equivalence of methylene protons of N-benzyl group in N-benzyl aziridines and their adducts
K. Matsumoto, T. Uchida, H. Iida, N. Hayashi, and R. A. Bulman
Heterocyclic Commun.   13(5) 263-266   2007   [Refereed]
K. Matsumoto, H. Iida, Y. Ikemi, A. Shigeta, M. Toda, N. Hayashi, R. A. Bulman
Heterocyclic Chem.   42(2) 191-199   2005   [Refereed]
K. Matsumoto, J. C. Kim, H. Iida, H. Hamana, K. Kumamoto, H. Kotsuki, and G. Jenner
Helv. Chim. Acta   88(7) 1734-1753   2005   [Refereed]
K. Matsumoto, H. Hamana, and H. Iida
Helv. Chim. Acta   88(8) 2033-2234   2005   [Refereed]
K. Kumamoto, H. Iida, H. Hamana, H. Kotsuki, and K. Matsumoto
Heterocycles   66 675-681   2005   [Refereed]
M. C. K. Choi, S.-S. Chan, M.-K. Chan, J. C. Kim, H. Iida, and K. Matsumoto
Heterocycles   62(1) 643-654   2004   [Refereed]
K. Matsumoto, S. Goto, N. Hayashi, H. Iida, T. Uchida, and A. Kakehi
Eur. J. Org. Chem.   (22) 4667-4671   2004   [Refereed]
H. Iida, H. Uekusa, Y. Ohashi, H. Hamana, T. Machiguchi, and K. Matsumoto
Heterocycles   64(1) 447-461   2004   [Refereed]
Z. Yuan, H. Iida, N. Inoue, Y. Ishikawa, and H. Ishida
Eur. J. Pharmacol.   464 197-206   2003   [Refereed]
Age-related Decreases in the Response of Aquaporin-5 to Acetylcholine in Rat Parotid Glands
N. Inoue, H. Iida, Z. Yuan, Y. Ishikawa, and H. Ishida
J. Dent. Res.   82(6) 476-480   2003   [Refereed]
T. Bando, H. Iida, Z.-F. Tao, A. Narita, N. Fukuda, T. Yamori, and H. Sugiyama
Chem. Biol.   10(8) 751-758   2003   [Refereed]
Phramacological principles of drug interaction essential for good dental practice
Yasuko IDHIKAWA, Hirokazu IIDA Hajime ISHIDA
14(2) 239-253   2002   [Refereed]
Y. Ishikawa, H. Iida, M. T. Skowronski, and H. Ishida
J. Pharmacol. Exp. Ther.   301(1), 1-12(1) 1-12   2002   [Refereed]
K. Fujimoto, H. Iida, M. Kawakami, T. Bando, Z.-F. Tao, and H. Sugiyama
Nucleic Acids Res.   30(17) 3748-3753   2002   [Refereed]
T. Bando, H. Iida, I. Saito, and H. Sugiyama
J. Am. Chem. Soc.   123(21) 5158-5159   2001   [Refereed]
G. Jia, H. Iida, and J. W. Lown
Synlett   (5) 603-606   2000   [Refereed]
H. Iida and H. Sugiyama
J. Synth. Org. Chem. Jpn.   58(10) 975-987   2000   [Refereed]
H. Iida, G. Jia, and J. W. Lown
Curr. Opin. Biotechnol.   10(1) 29-33   1999   [Refereed]
Design and synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) dimers
G. Jia, H. Iida, and J. W. Lown
Heterocyclic Commun.   5(6) 497-502   1999   [Refereed]
Synthesis of Bislexitropsin - 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indole-4-one (CBI) conjugates
G. Jia, H. Iida, and J. W. Lown
Heterocyclic Commun.   4 525-528   1998   [Refereed]
G. Jia, H. Iida, and J. W. Lown
Chem. Commun.   (2) 119-120   1999   [Refereed]
SNAr Reactions of Methyl and Ethyl 2-Nitro-5-fluorobenzoates in the Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine precursors
H. Iida, T. Misumi, T. Morishita, K. Matsumoto, and J. W. Lown
Heterocyclic Commun.   5(6), 509-514(6) 509-514   1999   [Refereed]
Design and Synthesis of Cyclopropylpyrroloindole (CPI) - Lexitropsin Conjugates and Related Structures
H. Iida and J. W. Lown
Recent Res. Devel. in Synth. Organic Chem.   1 16-45   1998   [Refereed]
Practical Route to Introduce Lexitropsins Possessing A Natural Trisulfide (-SSS-) Linker; Synthesis of N-(Lexitropsin-thiosulfenyl)phthalimides
H. Iida and J. W. Lown
Heterocyclic Commun.   4 557-560   1998   [Refereed]
Unusual formation and X-ray crystal structure of stable anti-Bredt compounds by reaction of 3a,6a-diazapentalenes with dimethyl acetylenedicarboxylate
K. Matsumoto, H. Iida, H. Katsura, T. Machiguchi, H. Uekusa, and Y. Ohashi
J. Chem. Soc., Perkin Trans. 1   2333-2335 2333-2335   1996   [Refereed]
K. Matsumoto, S. Okuno, H. Iida, and J. W. Lown
Heterocycles   40(2) 521-524   1995   [Refereed]
K. Matsumoto, K. Fukuyama, H. Iida, M. Toda, and J. W. Lown
Heterocycles   41(2) 237-244   1995   [Refereed]

Books etc

Seeds of separation technology and practical use of license technology
Hirokazu IIDA (Part:Joint Work, Introduction for process utilization of microwave irradiation method)
The Society of Separation Process Enineers, Japan (SSPEJ)   Jun 2019   
Introduction to Organic Chemistry
Hirokazu IIDA (Part:Joint Translation, Chapter 20. Nucleic acid)
Hirokawa Publishing Co.   May 2006   
Basic Organic Chemistry
Hirokazu IIDA (Part:Joint Work, Chapter 3, 5, and 6)
Apr 2005   
Human Genome Front Line
Isao SAITO, Hiroshi SUGIYAMA, Hirokazu IIDA, Kazuhiko NAKATANI, Shinsuke SANDO (Part:Joint Work, Bioorganic chemistry of post genome)
Kagaku-Dojin Publishing Company, INC   Jan 2001   

Conference Activities & Talks

Large scale application of microwave assisted Michael addition reaction [Invited]
Hirokazu IIDA
Sustainable Humanosphere Mission Symposium   25 Feb 2019   
Examination of advantage to microwave irradiation for addition reactions of enone and synthesis of acrylates
Hirokazu IIDA
16 Nov 2018   
Basic examination of microwave assisted organic reactions such as 1,4-addition toward process chemistry
Hirokazu IIDA
16 Nov 2018   
DFT verification of Microwave assisted Michael addition
Hirokazu IIDA, Shozo YANAGIDA
第11回日本電磁波エネルギー応用学会シンポジウム   10 Nov 2017   
Michael Addition of Anilines or Phenols without Solvent under Microwave Irradiation
Iida, H.; Takahashi, K.
Progress in Electromagnetics Research Symposium 2016   Aug 2016   
Microwave Assisted Michael Addition of Phenols or Anilines in the presence of DMAP
Iida, H.; Akatsu, Y.; Mizukami, K.; Takahashi, K.
3rd Global Congress on Microwave Energy Applications (3rd GCMEA)   Aug 2016   
Reactions of 3a,6a-Diazapentalenes with Dimethyl acetylenedicarboxylate : Formation of 1:2 Adduct
International Congress of Heterocyclic Chemistry   1995   
Sequence-specific DNA alkylation and cytotoxicities of imidazole-pyrroleamide-CPI conjugates with vinyl linker
Pacifichem 2000   2000   
Sequence-specific DNA alkylation and cytotoxicities of pyrrole-imidazolepolyamides-CPI conjugates with vinyl linkers
Symposium in Honor of Professor J. William Lown   2001   
The ACh- and pilocarpine induced increase in AQP5 levels in the APM in rat parotid acinar cells coupled with activation on NO/cGMA signal transduction
XIVth World Congress of Pharmacology   2002   
Effect of M3 muscarinic receptor agonists on amylase secretion via NO/PKG signaling pathway in rat parotid glands
The 4th International Symposium on Receptor Transduction and Drug Effects   2003   
High Pressure and Microwave Mediated Synthesis of 2-pyridones by Hilbert-Johnson Reaction
22nd International Congress of Heterocyclic Chemistry   2009   

Research Grants & Projects

Basic data collection for the enormous volume synthetic applicability of the microwave assisted Michael addition 3
Kyoto University: Analysis and Development System for Advanced Materials (ADAM)
Project Year: Apr 2019 - Feb 2020    Investigator(s): Hirokazu IIDA
Basic data collection for the enormous volume synthetic applicability of the microwave assisted Michael addition 2
Kyoto University: Analysis and Development System for Advanced Materials (ADAM)
Project Year: Apr 2018 - Feb 2019    Investigator(s): Hirokazu IIDA
Basic data collection for the enormous volume synthetic applicability of the microwave assisted Michael addition
Kyoto University: Analysis and Development System for Advanced Materials (ADAM)
Project Year: Apr 2017 - Feb 2018    Investigator(s): Hirokazu IIDA
Development of system for synthesis of Py-Im polyamide causing useful phenotypes to plants
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2013 - Mar 2016    Investigator(s): Youichi KONDOU
The role of glycolipids and peptideglycan of laptic acid bacteria for the stimulation of innate immunity
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2012 - Mar 2015    Investigator(s): KazuyoshI KAWAHARA
Super-molecule structure analyzer
Ministry of Education, Culture, Sports, Science and Technology: 
Project Year: Apr 2014 - Mar 2015    Investigator(s): Hirokazu IIDA
Development of new ant-Altzheimer
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2009 - Mar 2012    Investigator(s): Hiroshi HAMANA
Synthesis and mechanism of action ofNMDA i hibitor memantine derivatives
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2006 - Mar 2009    Investigator(s): Hiroshi HAMANA
Synthesis and development for sequence selective DNA alkylating agents
Japan Society for the Promotion of Science: Grant-in-Aid for Young Scientists (B)
Project Year: Apr 2004 - Mar 2006    Investigator(s): Hirokazu IIDA
Failure of compartmentlization of salivary gland acinor cell and development of the curative by diabetes
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2003 - Mar 2005    Investigator(s): Yasuko ISHIKAWA
Genetic analysis based on a comprehensive cDNA base sequence to selective expressed at pancreas beta cell
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2003 - Mar 2005    Investigator(s): Katsuhiko YOSHIMOTO
Aquaporin and saliva secretion
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research on Priority Areas
Project Year: Apr 2001 - Mar 2005    Investigator(s): Hajime ISHIDA
The development by which saliva secretion is incomplete development mechanism by diabetes and genom curative
Japan Society for the Promotion of Science: Grant-in-Aid for Scientific Research (B)
Project Year: Apr 2001 - Mar 2004    Investigator(s): Yasuko ISHIKAWA
Rational recognition of nuclei acid sequence by synthetic compounds
Project Year: 1996   
Microwave assisted organic reactions
Project Year: 2004   
High Pressure assisted organic reactions
Project Year: 1994   


Method of the solid phase synthesis of pyrrole-imidazole polyamide
PIXXD2 WO 0300683 A1 20030103