2015年6月
ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis
CELL REPORTS
- 巻
- 11
- 号
- 10
- 開始ページ
- 1625
- 終了ページ
- 1637
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.celrep.2015.05.019
- 出版者・発行元
- CELL PRESS
ASXL2 is an ETP family protein that interacts with PPAR gamma. We find that ASXL2-/- mice are insulin resistant, lipodystrophic, and fail to respond to a high-fat diet. Consistent with genetic variation at the ASXL2 locus and human bone mineral density, ASXL2-/- mice are also severely osteopetrotic because of failed osteoclast differentiation attended by normal bone formation. ASXL2 regulates the osteoclast via two distinct signaling pathways. It induces osteoclast formation in a PPAR gamma/c-Fos-dependent manner and is required for RANK ligand-and thiazolidinedione-induced bone resorption independent of PGC-1 beta. ASXL2 also promotes osteoclast mitochondrial biogenesis in a process mediated by PGC-1 beta but independent of c-Fos. Thus, ASXL2 is a master regulator of skeletal, lipid, and glucose homeostasis.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.celrep.2015.05.019
- ISSN : 2211-1247
- PubMed ID : 26051940
- Web of Science ID : WOS:000356372100013