2017年11月
Retinoic acid is required and Fgf, Wnt, and Bmp signaling inhibit posterior lateral line placode induction in zebrafish
DEVELOPMENTAL BIOLOGY
- ,
- ,
- ,
- 巻
- 431
- 号
- 2
- 開始ページ
- 215
- 終了ページ
- 225
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.ydbio.2017.09.017
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
The lateral line system is a mechanosensory systems present in aquatic animals. The anterior and posterior lateral lines develop from anterior and posterior lateral line placodes (aLLp and pLLp), respectively. Although signaling molecules required for the induction of other cranial placodes have been well studied, the molecular mechanisms underlying formation of the lateral line placodes are unknown. In this study we tested the requirement of multiple signaling pathways, such as Wnt, Bmp Fgf, and Retinoic Acid for aLLp and pLLp induction. We determined that aLLp specification requires Fgf signaling, whilst pLLp specification requires retinoic acid which inhibits Fgf signaling. pLLp induction is also independent of Wnt and Bmp activities, even though these pathways limit the boundaries of the pLLp. This is the first report that the aLLp and pLLp depend on different inductive mechanisms and that pLLp induction requires the inhibition of Fgf, Wnt and Bmp signaling.
- リンク情報
- ID情報
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- DOI : 10.1016/j.ydbio.2017.09.017
- ISSN : 0012-1606
- eISSN : 1095-564X
- PubMed ID : 28923486
- Web of Science ID : WOS:000414622200011