YANAKA Noriyuki

J-GLOBAL         Last updated: Aug 7, 2019 at 02:48
YANAKA Noriyuki
Hiroshima University
Ph.D. Agriculture(Kyoto University)
Research funding number


Studies on the relationship between food factors and diseases.

Research Areas


Academic & Professional Experience

Apr 1991
Nov 2001
Researcher, Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
Dec 2001
Mar 2019
Associate professor, Faculty of Applied Biological Science, Hiroshima University


Apr 1989
Mar 1991
Graduate School, Division of Agriculture, Kyoto University
Apr 1985
Mar 1989
Faculty of Agriculture, Kyoto University

Awards & Honors

The Japan Bioscience, Biotechnology, and Agrochemistry Society Award for the Encouragement of Young Scientists in 2005.

Published Papers

GDE5 inhibition accumulates intracellular glycerophosphocholine and suppresses adipogenesis at a mitotic clonal expansion stage
Okazaki, Yuri; Nakamura, Keishi; Takeda, Shuto; Yoshizawa, Ikumi; Yoshida, Fumiyo; Ohshima, Noriyasu; Izumi, Takashi; Klein, Janet D.; Kumrungsee, Thanutchaporn; Sands, Jeff M.; Yanaka, Noriyuki
Am. J. Physiol. Cell Physiol.   316(2) C162-C174   Feb 2019   [Refereed]
Mammalian glycerophosphodiesterases (GDEs) were recently shown to be involved in multiple cellular signaling pathways. This study showed that decreased GDE5 expression results in accumulation of intracellular glycerophosphocholine (GPC), showing t...
Novel metabolic disturbances in marginal vitamin B6-deficient rat heart.
Kumrungsee T, Nirmagustina DE, Arima T, Onishi K, Sato K, Kato N, and Yanaka N
J. Nutr. Biochem.   65 26-34   Mar 2019   [Refereed]
Yang, Bo; Kumoto, Takahiro; Arima, Takeshi; Nakamura, Minako; Sanada, Yohei; Kumrungsee, Thanutchaporn; Sotomaru, Yusuke; Shimada, Masayuki; Yanaka, Noriyuki
Genes Cells   23(3) 136-145   Mar 2018   [Refereed]
To determine adipocytokines that play a regulatory role during obesity development, we explored the genes that encode growth factors and investigated the physiological functions for adipose tissue development. Here, we isolated amphiregulin (Areg)...
Kameda, Tsuyoshi; Aoki, Hideyuki; Yang, Yongshou; Nirmagustina, Dwi Eva; Iwamoto, Akane; Kumrungsee, Thanutchaporn; Kato, Norihisa; Yanaka, Noriyuki
J. Nutr. Sci. Vitaminol. (Tokyo).   64(5) 379-383   2018   [Refereed]
The regional standard for tempeh established by the Codex Alimentarius defines the use of Rhizopus oligosporus, R. oryzae, and/or R. stolonifer as soybean tempeh starters. However, comparative studies on the functions of tempeh prepared with these...
Yang, Yongshou; Kameda, Tsuyoshi; Aoki, Hideyuki; Nirmagustina, Dwi Eva; Iwamoto, Akane; Kato, Norihisa; Yanaka, Noriyuki; Okazaki, Yukako; Kumrungsee, Thanutchaporn
Journal of Functional Foods   49 162-167   Oct 2018   [Refereed]
Tempe fermented with Rhizopus microsporus has several health benefits. However, the effects of tempe fermented with other fungal species of the genus Rhizopus are largely unknown. Rats were fed a high-fat diet, which was supplemented with 20% temp...
Nirmagustina, Dwi Eva; Yang, Yongshou; Kumrungsee, Thanutchaporn; Yanaka, Noriyuki; Kato, Norihisa
J. Nutr. Sci. Vitaminol (Tokyo).   64(2) 116-128   2018   [Refereed]
Colon diseases can be affected by several factors such as gender difference and dietary supplemental vitamin B-6 (B-6). The nutritional status of B-6 is affected by gender difference, leading us to hypothesize that gender difference affects colon ...
Mitsumoto, Koji; Watanabe, Rina; Nakao, Katsuki; Yonenaka, Hisaki; Hashimoto, Takao; Kato, Norihisa; Kumrungsee, Thanutchaporn; Yanaka, Noriyuki
Life Sciences   184 103-111   Sep 2017   [Refereed]
Aims: Choline-deficient diet is extensively used as a model of nonalcoholic fatty liver disease (NAFLD). In this study, we explored genes in the liver for which the expression changed in response to the choline-deficient (CD) diet. Main methods: M...
Suidasari, Sofya; Uragami, Shinji; Yanaka, Noriyuki; Kato, Norihisa
Exp. Ther. Med.   14(4) 3239-3246   Oct 2017   [Refereed]
Previous studies have suggested that vitamin B6 is an ergogenic factor. However, the role of dietary vitamin B6 in skeletal muscle has not been widely researched. The aim of the present study was to investigate the effects of dietary vitamin B6 on...
Limpimwong, Wanwanut; Kumrungsee, Thanutchapom; Kato, Norihisa; Yanaka, Noriyuki; Thongngam, Masubon
Journal of Functional Foods   39 250-256   Dec 2017   [Refereed]
Rice bran wax (RBW) rice bran oil (RBO) oleogel is an alternative structured fat used to replace saturated and trans fats. Our study investigated the effects of the RBW crystal network structure of oleogel on lipid digestibility compared with marg...
Yoshida, Ichiro; Ito, Chihiro; Matsuda, Shinya; Tsuji, Akihiko; Yanaka, Noriyuki; Yuasa, Keizo
Biosci. Biotechnol. Biochem.   81(3) 534-540   2017   [Refereed]
To develop new whitening agents from natural products, we screened 80 compounds derived from crude drugs in Kampo medicine in a melanin synthesis inhibition assay using murine B16 melanoma cells. The screen revealed that treatment with alisol B, a...
Tsujita, Natsumi; Kuwahara, Hiroyuki; Koyama, Hiroki; Yanaka, Noriyuki; Arakawa, Kenji; Kuniyoshi, Hisato
Biosci. Biotechnol. Biochem.   81(5) 938-950   2017   [Refereed]
The life cycle of the moon jellyfish, Aurelia aurita, alternates between a benthic asexual polyp stage and a planktonic sexual medusa (jellyfish) stage. Transition from polyp to medusa is called strobilation. To investigate the molecular mechanism...
Nakamura, Minako; Kumrungsee, Thanutchaporn; Sakuma, Tetsushi; Yamamoto, Takashi; Yanaka, Noriyuki
Biosci. Biotechnol. Biochem.   81(11) 2164-2167   2017   [Refereed]
In this study, we investigated the physiological function of glycerophosphodiesterase 5 (GDE5) in the proliferation of NIH3T3 fibroblasts. We used transcription activator-like effector nuclease (TALEN) in NIH3T3 cells with an intron targeting-medi...
Sanada, Yohei; Yamamoto, Takafumi; Satake, Rika; Yamashita, Akiko; Kanai, Sumire; Kato, Norihisa; van de Loo, Fons A. J.; Nishimura, Fusanori; Scherer, Philipp E.; Yanaka, Noriyuki
Scientific Reports   6    Dec 2016   [Refereed]
The infiltration of macrophages into adipose tissue and their interaction with adipocytes are essential for the chronic low-grade inflammation of obese adipose tissue. In this study, we identified the serum amyloid A3 (Saa3) gene as a key adipocyt...
Hashimoto, Takao; Yang, Bo; Okazaki, Yuri; Yoshizawa, Ikumi; Kajihara, Kaori; Kato, Norihisa; Wada, Masanobu; Yanaka, Noriyuki
PLoS One   11(9)    Sep 2016   [Refereed]
Glycerophosphodiesterase 5 (GDE5) selectively hydrolyses glycerophosphocholine to choline and is highly expressed in type II fiber-rich skeletal muscles. We have previously generated that a truncated mutant of GDE5 (GDE5dC471) that lacks phosphodi...
Kaji, Tomohiro; Hijikata, Atsushi; Ishige, Akiko; Kitami, Toshimori; Watanabe, Takashi; Ohara, Osamu; Yanaka, Noriyuki; Okada, Mariko; Shimoda, Michiko; Taniguchi, Masaru; Takemori, Toshitada
Int. Immunol.   28(6) 267-282   Jan 2016   [Refereed]
Memory CD4(+) T cells promote protective humoral immunity; however, how memory T cells acquire this activity remains unclear. This study demonstrates that CD4(+) T cells develop into antigen-specific memory T cells that can promote the terminal di...
Nakagawa, Yoshiko; Sakuma, Tetsushi; Nishimichi, Norihisa; Yokosaki, Yasuyuki; Yanaka, Noriyuki; Takeo, Toru; Nakagata, Naomi; Yamamoto, Takashi
Biol. Open   5(8) 1142-1148   Aug 2016   [Refereed]
Current advances in producing genetically modified mice using genome-editing technologies have indicated the need for improvement of limiting factors including zygote collection for microinjection and their cryopreservation. Recently, we developed...
Kawai, Tomoko; Yanaka, Noriyuki; Richards, JoAnne S.; Shimada, Masayuki
Endocrinology   157(5) 2160-2172   May 2016   [Refereed]
Retinoic acid (RA) is the active form of vitamin A and is synthesized from retinol by two key enzymes, alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH). As the physiological precursor of RA, retinol impacts female reproductive fun...
Suidasari, Sofya; Stautemas, Jan; Uragami, Shinji; Yanaka, Noriyuki; Derave, Wim; Kato, Norihisa
Front. Nutr.   2    Jan 2016   [Refereed]
Carnosine, a histidine-containing dipeptide, is well known to be associated with skeletal muscle performance. However, there is limited information on the effect of dietary micronutrients on muscle carnosine level. Pyridoxal 5'-phosphate (PLP), th...
Ohshima, Noriyasu; Kudo, Takahiro; Yamashita, Yosuke; Mariggio, Stefania; Araki, Mari; Honda, Ayako; Nagano, Tomomi; Isaji, Chiaki; Kato, Norihisa; Corda, Daniela et al.
J. Biol. Chem.   290(7) 4260-4271   Feb 2015   [Refereed]
The known mammalian glycerophosphodiester phosphodiesterases (GP-PDEs) hydrolyze glycerophosphodiesters. In this study, two novel members of the mammalian GP-PDE family, GDE4 and GDE7, were isolated, and the molecular basis of mammalian GP-PDEs wa...
Suidasari, Sofya; Hasegawa, Tomoko; Yanaka, Noriyuki; Kato, Norihisa
Springerplus   4 280   May 2015   [Refereed]
This study was performed to examine the effect of dietary level of vitamin B6 on the concentrations of carnosine and anserine, antioxidants, in the heart of rats. Analysis using UPLC-MS/MS showed that the concentrations of these dipeptides in the ...
Watanabe, Daiki; Kanzaki, Keita; Kuratani, Mai; Matsunaga, Satoshi; Yanaka, Noriyuki; Wada, Masanobu
J. Muscle Res. Cell Motil.   36(3) 275-286   Jun 2015   [Refereed]
The aim of this study was to examine whether prolonged low-frequency force depression (PLFFD) that occurs in situ is the result of decreased myofibrillar Ca2+ sensitivity and/or reduced sarcoplasmic reticulum (SR) Ca2+ release. Intact rat gastrocn...
Sanada, Yohei; Kumoto, Takahiro; Suehiro, Haruna; Yamamoto, Takafumi; Nishimura, Fusanori; Kato, Norihisa; Yanaka, Noriyuki
Biosci. Biotechnol. Biochem.   78(8) 1357-1362   Aug 2014   [Refereed]
Macrophage infiltration in the adipose tissue, and the interaction with adipocytes, is well documented to be involved in fat inflammation and obesity-associated complications. In this study, we isolated I kappa B kinase epsilon (IKK epsilon) as a ...
Haraguchi, Tomoaki; Kayashima, Tomoko; Okazaki, Yukako; Inoue, Junji; Mineo, Shigeru; Matsubara, Kiminori; Sakaguchi, Ei; Yanaka, Noriyuki; Kato, Norihisa
J. Agrc. Food Chem.   62(24) 5589-5594   Jun 2014   [Refereed]
This study demonstrated that 0.5% dietary rutin, ellagic acid, or curcumin markedly increased cecal succinate levels in rats fed a high-fat diet, whereas catechin, caffeic acid, and quercetin did not. Other organic acids were modestly or hardly af...
Zhang, Peipei; Suidasari, Sofya; Hasegawa, Tomomi; Yanaka, Noriyuki; Kato, Norihisa
Oncol. Rep.   31(5) 2371-2376   May 2014   [Refereed]
Increasing evidence indicates vitamin B-6 acts as a protective factor against colon cancer. However, the mechanisms of the effect of vitamin B-6 are poorly understood. The present preliminary study using DNA microarray and real-time PCR indicates ...
Kanzaki, Keita; Kuratani, Mai; Matsunaga, Satoshi; Yanaka, Noriyuki; Wada, Masanobu
J. Muscle Res. Cell Motil.   35(2) 179-189   Apr 2014   [Refereed]
The present study investigated changes in autolysis of three calpain isoforms in skeletal muscles undergoing eccentric contractions (ECC), leading to prolonged force deficits. Rat extensor digitorum longus and tibialis anterior muscles were expose...
The emerging physiological roles of the glycerophosphodiesterase family
Corda, Daniela; Mosca, Maria G.; Ohshima, Noriyasu; Grauso, Laura; Yanaka, Noriyuki; Mariggio, Stefania
FEBS J.   281(4) 998-1016   Feb 2014   [Refereed]
Zhang, Peipei; Suidasari, Sofya; Hasegawa, Tomomi; Yanaka, Noriyuki; Kato, Norihisa
Mol. Med. Rep.   8(4) 973-978   Oct 2013   [Refereed]
Increasing evidence suggests that dietary vitamin B6 is linked to the prevention of cancer and cardiovascular disease. However, the molecular mechanisms involved in this process are not yet understood. Preliminary results in the current study indi...
Sanada, Yohei; Kumoto, Takahiro; Suehiro, Haruna; Nishimura, Fusanori; Kato, Norihisa; Hata, Yutaka; Sorisky, Alexander; Yanaka, Noriyuki
PLoS One   8(4) e61931   Apr 2013   [Refereed]
Macrophage infiltration into adipose tissue is associated with obesity and the crosstalk between adipocytes and infiltrated macrophages has been investigated as an important pathological phenomenon during adipose tissue inflammation. Here, we soug...
Comparative study on the responses of concentrations of B-6-vitamers in several tissues of mice to the dietary level of pyridoxine
Masisi, Kabo; Suidasari, Sofya; Zhang, Peipei; Okazaki, Yukako; Yanaka, Noriyuki; Kato, Norihisa
J. Nutr. Sci. Vitaminol (Tokyo).   58(6) 446-451   Dec 2012   [Refereed]
To examine the responses of the levels of B-6-vitamers in several tissues to the dietary level of pyridoxine (PN), mice were fed diets containing 0, 1, 7 (the recommended level) or 35 mg PN HCl/kg diet for 5 wk. Compared with the 0 mg PN HCl/kg di...
Consumption of vitamin B-6 reduces fecal ratio of lithocholic acid to deoxycholic acid, a risk factor for colon cancer, in rats fed a high-fat diet
Okazaki, Yukako; Utama, Zaki; Suidasari, Sofya; Zhang, Peipei; Yanaka, Noriyuki; Tomotake, Hiroyuki; Sakaguchi, Ei; Kato, Norihisa
J. Nutr. Sci. Vitaminol (Tokyo).   58(5) 366-370   Oct 2012   [Refereed]
To examine the effect of supplemental dietary vitamin B-6 on the colonic luminal environment, growing male rats were fed a high-fat diet containing 1, 7, or 35 mg pyridoxine HCl/kg diet for 6 wk. Food intake and growth were unaffected by the dieta...
Toya, Keigo; Hirata, Atsuko; Ohata, Tomomi; Sanada, Yohei; Kato, Norihisa; Yanaka, Noriyuki
Mol. Nutr. Food Res.   56(4) 641-652   Apr 2012   [Refereed]
Scope: Previous studies have shown that vitamin B6 supplementation suppresses the development of colonic aberrant crypt foci (ACF), precursor lesions of colon cancer, and cell proliferation in mice receiving the colonic carcinogen, azoxymethane (A...
Yanaka, Noriyuki; Ohata, Tomomi; Toya, Keigo; Kanda, Mayumi; Hirata, Atsuko; Kato, Norihisa
Mol. Nutr. Food Res.   55(4) 635-643   Apr 2011   [Refereed]
Scope: Previous reports in the areas of animal studies and, recently epidemiology, have linked anti-tumorigenic and anti-inflammatory effects to dietary vitamin B6. This study investigated the molecular mechanism of these effects of vitamin B6. Me...
Kayashima, Tomoko; Tanaka, Kenta; Okazaki, Yukako; Matsubara, Kiminori; Yanaka, Noriyuki; Kato, Norihisa
Oncol. Lett.   2(6) 1243-1246   Nov 2011   [Refereed]
Mounting evidence indicates that vitamin B6 is a protective factor for colon cancer. Elevations in colonic damage, cell proliferation and heat shock proteins (HSPs, molecular chaperones) have been suggested to be associated with colon carcinogenes...
Haraguchi, Tomoaki; Yanaka, Noriyuki; Eguchi, Yuko; Kudo, Takahiro; Hirata, Atsuko; Kato, Norihisa
Biosci. Biotechnol. Biochem.   75(7) 1383-1385   Jul 2011   [Refereed]
In this study, we investigated the effect of fish oil on gene expression in the cerebral cortex, and found that 5-aminolevulinate synthase 2 (ALAS2) mRNA expression was up-regulated by fish oil feeding. ALAS2 promoter activity was found to be regu...
Yanaka, Noriyuki; Kanda, Mayumi; Toya, Keigo; Suehiro, Haruna; Kato, Norihisa
Exp. Ther. Med.   2(3) 419-424   May 2011   [Refereed]
We previously demonstrated that vitamin B6 suppresses tumorigenesis in the colon of mice and exerts an anti-inflammatory effect through the inhibition of NF-kappa B activation. As these effects resemble the pharmacological properties of thiazolidi...
Okazaki, Yuri; Ohshima, Noriyasu; Yoshizawa, Ikumi; Kamei, Yasutomi; Mariggio, Stefania; Okamoto, Keiko; Maeda, Masahiro; Nogusa, Yoshihito; Fujioka, Yuichiro; Izumi, Takashi et al.
J. Biol. Chem.   285(36) 27652-27663   Sep 2010   [Refereed]
Mammalian glycerophosphodiester phosphodiesterases (GP-PDEs) have been identified recently and shown to be implicated in several physiological functions. This study isolated a novel GP-PDE, GDE5, and showed that GDE5 selectively hydrolyzes glycero...
Kanzaki, Keita; Kuratani, Mai; Mishima, Takaaki; Matsunaga, Satoshi; Yanaka, Noriyuki; Usui, Sachio; Wada, Masanobu
Eur. J. Appl. Physiol.   110(5) 943-952   Nov 2010   [Refereed]
The present study investigated the effects of eccentric muscle contractions (ECC) on the content of myofibrillar proteins (my-proteins) and the catalytic activity of myofibrillar ATPase (my-ATPase) in skeletal muscles. Rat extensor digitorum longu...
Dairaku, Issei; Han, Yunkyung; Yanaka, Noriyuki; Kato, Norihisa
Biosci. Biotechnol. Biochem.   74(1) 185-187   Jan 2010   [Refereed]
Inosine monophosphate dehydrogenase (IMPDH), a rate-limiting enzyme in the de novo synthesis of guanine nucleotides, is a therapeutic target for anticancer and antiviral agents. Among the 15 different polyphenols examined, curcumin was found to ha...
Generation of a zinc finger protein ZPR1 mutant that constitutively interacted with translation elongation factor 1alpha.
Yanaka N, Kaseda Y, Tanaka A, Nogusa Y, Sumiyoshi N, Kato N.
Biosci. Biotechnol. Biochem.   73(12) 2809-2811   Dec 2009   [Refereed]
Corda D, Kudo T, Zizza P, Iurisci C, Kawai E, Kato N, Yanaka N, Mariggi? S.
J. Biol. Chem.   284(37) 24848-24856   Sep 2009   [Refereed]
Hirata, Toshifumi; Fujii, Misato; Akita, Kazuhiro; Yanaka, Noriyuki; Ogawa, Kaori; Kuroyanagi, Masanori; Hongo, Daiki
Bioorg. Med. Chem.   17(1) 25-28   Jan 2009   [Refereed]
On the basis of monitoring the prevention of accumulation of lipid droplets in mouse 3T3-L1 preadipocyte cells and inhibition of the proliferation of human colon cancer HT-29 cells, effective anti-corpulence and anticancer compounds were isolated ...
Mammalian glycerophosphodiester phosphodiesterases.
Biosci. Biotechnol. Biochem.   71(8) 1811-1818   Aug 2007   [Refereed][Invited]
Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase
Mizushina Y, Dairaku I, Yanaka N, Takeuchi T, Ishimaru C, Sugawara F, Yoshida H, Kato N.
Biochimie   89 581-590   May 2007   [Refereed]
Yanaka N
Biosci. Biotechnol. Biochem.   71(8) 1811-1818   Apr 2007   [Refereed]
Bacterial glycerophosphodiester phosphodiesterases (GP-PDEs), G1pQ and UgpQ, are well-characterized periplasmic and cytosolic proteins that play critical roles in the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol,...
Involvement of membrane protein GDE2 in retinoic acid-induced neurite formation in Neuro2A cells.
Yanaka N, Nogusa Y, Fujioka Y, Yamashita Y, Kato N.
FEBS Lett.   581(4) 712-718   Feb 2007   [Refereed]
Expression of ADP-ribosylation factor-like protein 8B mRNA in the brain is down-regulated in mice fed a high-fat diet.
Haraguchi T, Yanaka N, Nogusa Y, Sumiyoshi N, Eguchi Y, Kato N.
Biosci. Biotechnol. Biochem.   581(4) 712-718   Jul 2006   [Refereed]
Expression of zinc finger protein ZPR1 mRNA in brain is up-regulated in mice fed a high-fat diet.
Nogusa Y, Yanaka N, Sumiyoshi N, Takeda K, Kato N.
Int. J. Mol. Med.   17(3) 491-496   Mar 2006   [Refereed]
High protein buckwheat flour suppresses hypercholesterolemia in rats and gallstone formation in mice by hypercholesterolemic diet and body fat in rats because of its low protein digestibility.
Tomotake H, Yamamoto N, Yanaka N, Ohinata H, Yamazaki R, Kayashita J, Kato N.
Nutrition   22 166-173   Jan 2006   [Refereed]
Vitamin B6 suppresses NF-kappaB activation in LPS-stimulated mouse macrophages.
Yanaka N, Koyama TA, Komatsu S, Nakamura E, Kanda M, Kato N.
Int. J. Mol. Med.   16(6) 1071-1075   Dec 2005   [Refereed]
A high-fat diet enhances the inhibitory effect of dietary vitamin B6 on colon cell proliferation in mice
Komatsu S, Isobe M, Yanaka N, Kato N.
Oncology Reports   14 265-269   May 2005   [Refereed]
Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice
Hashimoto T, Fukunari A, Yamada I, Yanaka N, Chen D, Kato N.
Biosci. Biotechnol. Biochem.   69 209-211   Feb 2005   [Refereed]
Short-term feeding of fish oil down-regulates the expression of pyruvate dehydrogenase E1 alpha subunit mRNA in mouse brain.
Nogusa Y, Yanaka N, Sumiyoshi N, Kaseda Y, Tsuboyama-Kasaoka N, Ezaki O, Kato N.
Biosci. Biotechnol. Biochem.   69(2) 301-306   Feb 2005   [Refereed]
Isolation and characterization of two serpentine membrane proteins containing glycerophosphodiester phosphodiesterase, GDE2 and GDE6.
Nogusa Y, Fujioka Y, Komatsu R, Kato N, Yanaka N.
Gene   337 173-179   Aug 2004   [Refereed]
Novel membrane protein containing glycerophosphodiester phosphodiesterase motif is transiently expressed during osteoblast differentiation.
Yanaka N, Imai Y, Kawai E, Akatsuka H, Wakimoto K, Nogusa Y, Kato N, Chiba H, Kotani E, Omori K, Sakurai N.
J. Biol. Chem.   278(44) 43595-43602   Oct 2003   [Refereed]
cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles.
Yanaka N, Kurosawa Y, Minami K, Kawai E, Omori K.
Biosci. Biotechnol. Biochem.   67(5) 973-979   May 2003   [Refereed]
Inhibitory effects of silk protein, sericin on UVB-induced acute damage and tumor promotion by reducing oxidative stress in the skin of hair less mouse.
Zhaorigetu S, Yanaka N, Sasaki M, Watanabe H, Kato N.
J. Photochem. Photobiol. B: Biology   71 11-17   Apr 2003   [Refereed]
Antitumor effect of vitamin B6 and its mechanism
Komatsu S, Yanaka N, Matsubara K, Kato N.
Biochim. Biophys. Acta   1647 127-130   Apr 2003   [Refereed]
Developmental expression of Na+/Ca2+ exchanger (NCX1) gene in the mouse embryo
Wakimoto K, Kuro-o M, Yanaka N, Komuro I, Nabeshima YI, Imai Y.
Comp. Biochem. Physiol.   130(2) 191-198   Sep 2001   [Refereed]
Human Ca(2+)/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization
Michibata H, Yanaka N, Kanoh Y, Okumura K, Omori K.
Biochim. Biophys. Acta   1517(2) 278-287   Jan 2001   [Refereed]
Targeted disruption of Na+/Ca2+ exchanger gene leads to cardiomyocyte apoptosis and defects in heartbeat
Wakimoto K, Kobayashi K, Kuro-O M, Yao A, Iwamoto T, Yanaka N, Kita S, Nishida A, Azuma S, Toyoda Y, Omori K, Imahie H, Oka T, Kudoh S, Kohmoto O, Yazaki Y, Shigekawa M, Imai Y, Nabeshima Y, Komuro I.
J. Biol. Chem.   275(47) 36991-36998   Nov 2000   [Refereed]
Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis
Yanaka N, Kobayashi K, Wakimoto K, Yamada E, Imahie H, Imai Y, Mori C.
J. Biol. Chem.   275(20) 14791-14794   May 2000   [Refereed]
Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha
Yuasa K, Omori K, Yanaka N.
J. Biol. Chem.   275(7) 4897-4905   Feb 2000   [Refereed]
The specific domain of cGMP -dependent protein kinase Ibeta but not Ialpha functions as a transcriptional activator in yeast
Yuasa K, Omori K, Yanaka N.
IUBMB Life   49(1) 17-22   Jan 2000   [Refereed]
Identification of a conserved residue responsible for the autoinhibition of cGMP-dependent protein kinase Ialpha and beta
Yuasa K, Michibata H, Omori K, Yanaka N.
FEBS Lett.   466(1) 175-178   Jan 2000   [Refereed]
Isolation and characterization of Na+/Ca2+ exchanger gene and splicing isoforms in mice
Wakimoto K, Kuro-O M, Yanaka N, Omori K, Komuro I, Imai Y, Nabeshima Y.
DNA Seq.   11(42737) 75-81   Jan 2000   [Refereed]
A novel interaction of cGMP-dependent protein kinase I with troponin T
Yuasa K, Michibata H, Omori K, Yanaka N.
J. Biol. Chem.   274(52) 37429-37434   Dec 1999   [Refereed]
Alteration of cGMP metabolism during chondrogenic differentiation of chondroprogenitor-like EC cells, ATDC5
Fujishige K, Kotera J, Yanaka N, Akatsuka H, Omori K.
Biochim. Biophys. Acta   1452(3) 219-227   Dec 1999   [Refereed]
Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases
Kotera J, Fujishige K, Imai Y, Kawai E, Michibata H, Akatsuka H, Yanaka N, Omori K.
Eur. J. Biochem.   262(3) 866-873   Jan 1999   [Refereed]
1,25-Dihydroxyvitamin D3 upregulates natriuretic peptide receptor-C expression in mouse osteoblasts
Yanaka N, Akatsuka H, Kawai E, Omori K.
Am. J. Physiol.   275(42887) E965-973   Dec 1998   [Refereed]
Novel alternative splice variants of cGMP-binding cGMP-specific phosphodiesterase
Kotera J, Fujishige K, Akatsuka H, Imai Y, Yanaka N, Omori K.
J. Biol. Chem.   273(41) 26982-26990   Oct 1998   [Refereed]
Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene
Yanaka N, Kotera J, Ohtsuka A, Akatsuka H, Imai Y, Michibata H, Fujishige K, Kawai E, Takebayashi S, Okumura K, Omori K.
Eur. J. Biochem.   255(2) 391-399   Jul 1998   [Refereed]
Localization of clearance receptor in rat lung and trachea: association with chondrogenic differentiation
Fujishige K, Yanaka N, Akatsuka H, Omori K.
Am. J. Physiol.   274(42795) L425-431   May 1998   [Refereed]
Isolation and characterization of the 5’-flanking regulatory region of the human natriuretic peptide receptor C gene
Yanaka N, Kotera J, Omori K.
Endocrinology   139(3) 1389-1400   Mar 1998   [Refereed]
TMC-49A, a novel transcriptional up-regulator of low density lipoprotein receptor, produced by Streptomyces sp. AS1345.
Koguchi Y, Asai Y, Suzuki S, Nishio M, Yanaka N, Omori K, Ohnuki T, and Komatsubara S
J. Antibiot. (Tokyo)   51 111-111   1998   [Refereed]
Protein kinase C activation down-regulates natriuretic peptide receptor C expression via transcriptional and post-translational pathways.
Yanaka N, Akatsuka H, Omori K.
FEBS Lett.   418(3) 333-336   Dec 1997   [Refereed]
Expression of rat cGMP-binding cGMP-specific phosphodiesterase mRNA in Purkinje cell layers during postnatal neuronal development.
Kotera J, Yanaka N, Fujishige K, Imai Y, Akatsuka H, Ishizuka T, Kawashima K, Omori K.
Eur. J. Biochem.   249(2) 434-442   Oct 1997   [Refereed]
Structure of the 5'-flanking regulatory region of the mouse gene encoding the clearance receptor for atrial natriuretic peptide.
Yanaka N, Kotera J, Taguchi I, Sugiura M, Kawashima K, Omori K.
Eur. J. Biochem.   237(1) 25-34   Apr 1996   [Refereed]
Nitrilase from Rhodococcus rhodochrous J1. Sequencing and overexpression of the gene and identification of an essential cysteine residue.
Kobayashi M, Komeda H, Yanaka N, Nagasawa T, and Yamada H
J. Biol. Chem.   267 20746-20751   1992   [Refereed]
Primary structure of an aliphatic nitrile-degrading enzyme, aliphatic nitrilase, from Rhodococcus rhodochrous K22 and expression of its gene and identification of its active site residue.
Kobayashi M, Yanaka N, Nagasawa T, and Yamada H
Biochemistry   31 9000-9007   1992   [Refereed]
Hyperinduction of an aliphatic nitrilase by Rhodococcus rhodochrous K22.
Kobayashi M, Yanaka N, Nagasawa T, and Yamada H
FEMS Microbiol. Lett.   77 121-123   1991   [Refereed]
Monohydrolysis of an aliphatic dinitrile compound by nitrilase from Rhodococcus rhodochrous K22.
Kobayashi M, Yanaka N, Nagasawa T, and Yamada H
Tetrahedron   46 5587-5590   1990   [Refereed]
Nitrilase-catalyzed production of pyrazinoic acid, an antimycobacterial agent, from cyanopyrazine by resting cells of Rhodococcus rhodochrous J1.
Kobayashi M, Yanaka N, Nagasawa T, and Yamada H
J. Antibiot. (Tokyo)   43 1316-1320   1990   [Refereed]
Purification and characterization of a novel nitrilase of Rhodococcus rhodochrous K22 that acts on aliphatic nitriles.
Kobayashi M, Yanaka N, Nagasawa T, and Yamada H
J. Bacteriol.   172 4807-4815   1990   [Refereed]
Nitrilase-catalyzed production of para-aminobenzoic acid from para-aminobenzonitorile with Rhodococcus rhodochrous J1.
Kobayashi M, Nagasawa T, Yanaka N, and Yamada H
Biotechnol. lett.   11 27-30   1989   [Refereed]

Books etc

Science within Food: Up-to-date Advances on Research and Educational Ideas.
Kumrungsee T, Nirmagustina DE, Kato N, Yanaka N, and Lai HC: (Part:Joint Work)
Formatex Research Center.   Nov 2017   

Conference Activities & Talks

Dietary supplemental vitamin B6 increases concentrations of carnosine and anserine in the skeletal muscles and heart of rats.
Sofya Suidasari, Jan Stautemas, Noriyuki Yanaka, Wim Derave, Norihisa Kato.
The 6th International Conference on Food Factors   22 Nov 2015   ICoFF
Carnosine and anserine in skeletal muscles and heart are dependent on vitamin B6 status.
Sofya Suidasari, Jan Stautemas, Noriyuki Yanaka, Wim Derave, Norihisa Kato
12th European Nutrition Conference (FENS 2015)   23 Oct 2015   FENS
In vivo imaging model mice for assessing obese adipose inflammation and DSS-induced colon inflammation
Yohei Sanada, Takafumi Yamamoto, Sumire Kanai, Fusanori Nishimura, Fons van de Loo, Norihisa Kato and Noriyuki Yanaka
17th International Conference of FFC   15 Sep 2015   Functional food center
GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity.
Isaji C, Kudo T, Ohshima N, Yamashita Y, Araki M, Honda A, Nagano T, Kato N, Konishi A, Kishimoto K, Tatei K, Yanaka N, Izumi T
6th international conference on Phospholipase A2 and Lipid Mediators (PLM2015)   12 Feb 2015   
Transcriptomic analysis identities novel genes expression in response to choline deficiency in rat liver and in rat primary hepatocytes.
Rina Watanabe, Kouji Mitsumoto, Hisaki Yonenaka, Takao Hashimoto, Norihisa Kato, Noriyuki Yanaka
The 12th Asian Congress of Nutrition (ACN2015)   15 May 2015   Federation of Asian Nutrition Societies
In vivo imaging of adipose tissue inflammation by using Saa3 promoter activity.
Yohei Sanada, Takafumi Yamamoto, Sumire Kanai, Fusanori Nishimura, Fons van de Loo, Norihisa Kato, Noriyuki Yanaka
The 12th Asian Congress of Nutrition (ACN2015)   15 May 2015   Federation of Asian Nutrition Societies
Maternal choline deficiency affects offspring health.
Yoshiko Tsukuda, Yukino Miyachi, Takao Hashimoto, Norihisa Kato, Noriyuki Yanaka
The 12th Asian Congress of Nutrition (ACN2015)   15 May 2015   Federation of Asian Nutrition Societies
Effect of vitamin B6 on the expression of IGFBPs, anti-disease factors, in HepG2 cells
Sofya Suidasari, Peipei Zhang, Tomomi Hasegawa, Noriyuki Yanaka, Norihisa Kato
The 12th Asian Congress of Nutrition (ACN2015)   15 May 2015   Federation of Asian Nutrition Societies
Dietary supplemental vitamin B6 to a low vitamin B6 diet modulates gene expression of myokines in skeletal muscle of rats.
Shinji Uragami, Sofya Suidasari, Noriyuki Yanaka, Norihisa Kato
The 12th Asian Congress of Nutrition (ACN2015)   15 May 2015   Federation of Asian Nutrition Societies

Research Grants & Projects

JSPS: KAKENHI(Grant-in-Aid for Scientific Research (C))
Project Year: 2017 - 2019
Project Year: 2014 - 2016
Project Year: 2011 - 2013    Investigator(s): YANAKA, NORIYUKI
We previously showed that GDE5 is a cytosolic glycerophosphocholine (GPC) phosphodiesterase. Here, we characterized the cellular functions of GDE5 in adipocytes because GDE5 expression is highly expressed during 3T3-L1 adipocyte differentiation. K...
Project Year: 2009 - 2011    Investigator(s): KATO, Norihisa
This study was performed to examine why the anti-tumor effect of vitamin B6 is profound in the colon. This reason was explained by indicating the higher sensitivity of colon levels of B6-vitamers to dietary supplemental vitamin B6. Further study w...
Project Year: 2008 - 2010    Investigator(s): YANAKA, Noriyuki
This study isolated a novel GP-PDE, GDE5, and showed that GDE5 selectively hydrolyzes glycerophosphocholine (GroPCho). We show that that decreasing GDE5 abundance promoted myoblastic differentiation. Furthermore, transgenic mice specifically expre...
Project Year: 2006 - 2007    Investigator(s): YANAKA, Noriyuki
Bacterial glycerophosphodiester phosphodiesterases are well-characterized to be periplasmic and cytosolic proteins, which play a critical role in the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol. In contrast, two...
Project Year: 2015 - 2018
Project Year: 2012 - 2014
Project Year: 2006 - 2008
Project Year: 2005 - 2007    Investigator(s): KATO, Norihisa
Recently, vitamin B6 (B6) has been reported to prevent several diseases. This study was performed to examine the functions of 136 as an anti-ageing factor. Recent studies elucidate the important roles of NFkB-dependent inflammation both in the dev...
Project Year: 2003 - 2004