2018年5月1日
A double-blind, randomized comparative study to investigate the morphine to hydromorphone conversion ratio in Japanese cancer patients.
Japanese journal of clinical oncology
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- 巻
- 48
- 号
- 5
- 開始ページ
- 442
- 終了ページ
- 449
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1093/jjco/hyy046
- 出版者・発行元
- OXFORD UNIV PRESS
Objective: To confirm the morphine to hydromorphone conversion ratio for hydromorphone (DS-7113b) immediate-release tablets in cancer patients who achieved pain control with oral morphine. Methods: This was a multicenter, active-controlled, randomized, double-blind, parallel-group, comparative study (July 2013 to December 2014) at 39 Japanese sites. Seventy-one patients (aged >20 years) who had achieved pain control with morphine 60 mg/day and 90 mg/day were randomly allocated 1:1 to hydromorphone immediate-release tablets at a dose converted at a hydromorphone:morphine ratio of 1:5 or 1:8, respectively, and treated for up to 5 days. The efficacy was evaluated as the pain control ratio. Results: The pain control ratio in the full analysis set was 83.3% (25/30) in the conversion ratio 1:5 group and 95.0% (38/40) in the conversion ratio 1:8 group, and both groups demonstrated highly successful pain control. The incidence of adverse events was 46.7% (14/30) in the conversion ratio 1:5 group and 58.5% (24/41) in the 1:8 group; the difference was not clinically relevant. Frequently observed adverse events (incidence ≥5%) were nausea, vomiting, diarrhea, somnolence and dyspnea. Conclusions: A high pain control ratio was maintained by a switch at either conversion ratio, and no notable difference was observed in the incidence of adverse events. A switch from morphine to hydromorphone is effective at a dose converted at ratios of 1:5 and 1:8.
- リンク情報
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- DOI
- https://doi.org/10.1093/jjco/hyy046
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/29635632
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926545
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000431144300006&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1093/jjco/hyy046
- ISSN : 0368-2811
- eISSN : 1465-3621
- PubMed ID : 29635632
- PubMed Central 記事ID : PMC5926545
- Web of Science ID : WOS:000431144300006