SHIMIZU Akira

Last updated: Jun 27, 2019 at 11:09

Name	SHIMIZU Akira
Affiliation	Kyoto University
Section	Hospital, Translational Research Center, Department of Experimantal Therapeutics
Job title	Professor
Degree	Ph D(Osaka University)

Research Interests

gene organization(1) , gene expression(167) , immunoglobulin(5) , TCR(4) , chromatin structure(6)

Research Areas

Biological science / Molecular biology /
Basic medicine / General medical chemistry /
Basic medicine / Immunology /

Academic & Professional Experience

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1983

1984

Assistant Professor,

　　　　　　Osaka University Medical School

1984

1987

Assistant Professor,

　　　　　　Faculty of Medicine, Kyoto University

1986

1987

Research Fellow, Harvard Medical School

Education

Plain Text

1983

Genetics, Graduate School, Division of Medicine, Osaka University

1979

Medicine, Faculty of Medicine, The University of Tokyo

Published Papers

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Direct evidence for the age-dependent demise of GNAS-mutated cells in oral fibrous dysplasia

Isobe, Y., Takahashi, K., Kiso, H., Nakao, K., Ikeno, M., Koyama, N., Sugai, M., Shimizu, A., Haga, H. and Bessho, K.

Arch. Oral Biol. 93 133-140 Sep 2018 [Refereed]

A therapeutic angiogenesis of sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel sheets in a canine chronic myocardial infarction mode

Kumagai, M., Minakata, K., Masumoto, H., Yamamoto, M., Yonezawa, A., Ikeda, T., Uehara, K., Yamazaki, K., Ikeda, T., Matsubara, K., Yokode, M., Shimizu, A., Tabata, Y., Sakata, R., and Minatoya, K.

Heart and Vessels 33(10) 2151-2157 May 2018 [Refereed]

Loss of Stemness, EMT, and Supernumerary Tooth Formation in Cebpb−/−Runx2+/− Murine Incisors

Saito, K., Takahashi, K., Huang, B., Asahara, M., Kiso, H., Togo, Y., Tsukamoto, H., Mishima, S., Nagata, M., Iida, M., Tokita, Y., Asai, M., Shimizu, A., Komori, T., Harada, H., MacDougall, M., Sugai, M. and Bessho, K.

Scientific Reports 8 5169 Mar 2018 [Refereed]

Patterns of clinical practice for sentinel lymph node biopsy in women with node-negative breast cancer: the results of a national survey in Japan.

Ikeda, T., Sugie, T., Shimizu, A. and Toi, M.

Breast Cancer 24(2) 341-344 Mar 2017 [Refereed]

Sentinel lymph node biopsy using indocyanine green fluorescence in early-stage breast cancer: a meta-analysis.

Sugie, T., Ikeda, T., Kawaguchi, A, Shimizu, A. and Toi, M.

Internat. J. Clin. Oncology 22(1) 11-17 Feb 2017 [Refereed]

Transcutaneous oxygen pressure as a surrogate index of lower limb amputation.

Nishio, H., Minakata, K., Kawaguchi, A., Kumagai, M., Ikeda, T., Shimizu, A., Yokode, M., Morita, S. and Sakata, R.

Internat. Angiology 35(6) 565-572 Dec 2016 [Refereed]

Prognostic Impact of Salvage Treatment on Hearing Recovery in Patients with Sudden Sensorineural Hearing Loss Refractory to Systemic Corticosteroids: A retrospective Observational Study

Nakagawa, T., Yamamoto, M., Kumakawa, K., Usami, S., Hato, N., Tabuchi, K., Takahashi, M., Fujiwara, K., Sasaki, A., Komune, S., Yamamoto, N., Hiraumi, H., Sakamoto, T., Shimizu, A. and Ito, J.

Auris Nasus Larynx 43(5) 489-494 Oct 2016 [Refereed]

A pilot study of regenerative therapy using controlled release of recombinant human fibroblast growth factor for patients with pre-collapse osteonecrosis of the femoral head.

Kuroda, Y., Asada, R., So, K., Yonezawa, A., Nankaku, M., Mukai, K., Ito-Ihara, T., Tada, H., Yamamoto, M., Murayama, T., Morita, S., Tabata, Y., Yokode, M., Shimizu, A., Matsuda, S., and Akiyama, H.

Internat. Orthopaedics 40(8) 1747-1754 Aug 2016 [Refereed]

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.

Sato, Y., Mii, A., Hamazaki, Y., Fujita, H., Nakata, H., Masuda, K., Nishiyama, S., Shibuya, S., Haga, H., Ogawa, O., Shimizu, A., Narumiya, S., Kaisho, T., Arita, M., Yanagisawa, M., Miyasaka, M., Sharma, K., Minato, N., Kawamoto, H. and Yanagita, M.

JCI Insight 1 e87680 Jul 2016 [Refereed]

Effects of Usag-1 and Bmp7 deficiencies on Murine Tooth Morphogenesis

Saito, K., Takahashi, K., Asahara, M., Kiso, H., Togo, Y., Tsukamoto, H., Huang, B., Sugai, M., Shimizu, A., Motokawa, M., Slavkin, H. C .and Bessho, K.

BMC Dev. Biol. 16 14 May 2016 [Refereed]

Safety and efficacy of sustained release of basic fibroblast growth factor using gelatin hydrogel in patients with critical limb ischemia.

Kumagai M, Marui A, Tabata Y, Takeda T, Yamamoto M, Yonezawa A, Tanaka S, Yanagi S, Ito-Ihara T, Ikeda T, Murayama T, Teramukai S, Katsura T, Matsubara K, Kawakami K, Yokode M, Shimizu A, Sakata R

Heart and vessels 31(5) 713-721 May 2016 [Refereed]

Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer.

Hamanishi, J., Mandai, M., Ikeda, T., Minami, M., Kawaguchi, A., Murayama, T., Kanai, M., Mori, Y., Matsumoto, S., Chikuma, S., Matsumura, N., Abiko, K., Baba, T., Yamaguchi, K., Ueda, A., Hosoe, Y., Morita, S., Yokode, M., Shimizu, A., Honjo, T. and Konishi, I.

Journal of Clinical Oncology 33(34) 4015-4022 Dec 2015 [Refereed]

ANKH Polymorphisms and Clicking of the Temporomandibular Joint in Dental Residents.

Huang B, Takahashi K, Goto T, Kiso H, Sugai M, Shimizu A, Kosugi S, Bessho K

Journal of maxillofacial and oral surgery 14(2) 247-251 Jun 2015 [Refereed]

Activation of B1a cells in peritoneal cavity by T cell-independent antigen expressed on polymeric micelle.

Kim CJ, Hara E, Shimizu A, Sugai M, Kimura S

Journal of pharmaceutical sciences 104(5) 1839-1847 May 2015 [Refereed]

Mitochondrial function provides instructive signals for activation-induced B-cell fates.

Jang KJ, Mano H, Aoki K, Hayashi T, Muto A, Nambu Y, Takahashi K, Itoh K, Taketani S, Nutt SL, Igarashi K, Shimizu A, Sugai M

Nature communications 6 6750 Apr 2015 [Refereed]

Effects of zoledronic acid and the association between its efficacy and γδT cells in postmenopausal women with breast cancer treated with preoperative hormonal therapy: a study protocol.

Sumi E, Sugie T, Yoshimura K, Tada H, Ikeda T, Suzuki E, Tanaka Y, Teramukai S, Shimizu A, Toi M, Minato N

Journal of translational medicine 12 310 Nov 2014 [Refereed]

A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment.

Nakagawa T, Kumakawa K, Usami S, Hato N, Tabuchi K, Takahashi M, Fujiwara K, Sasaki A, Komune S, Sakamoto T, Hiraumi H, Yamamoto N, Tanaka S, Tada H, Yamamoto M, Yonezawa A, Ito-Ihara T, Ikeda T, Shimizu A, Tabata Y, Ito J

BMC medicine 12 219 Nov 2014 [Refereed]

Prospective signs of cleidocranial dysplasia in Cebpb deficiency.

Huang B, Takahashi K, Jennings EA, Pumtang-On P, Kiso H, Togo Y, Saito K, Sugai M, Akira S, Shimizu A, Bessho K

Journal of biomedical science 21 44 May 2014 [Refereed]

Functional evaluation of activation-dependent alterations in the sialoglycan composition of T cells

Y. Naito-Matsui; S. Takada; Y. Kano; T. Iyoda; M. Sugai; A. Shimizu; K. Inaba; L. Nitschke; T. Tsubata; S. Oka; Y. Kozutsumi; H. Takematsu

Journal of Biological Chemistry 289(3) 1564-1579 Jan 2014 [Refereed]

Preclinical validation of talaporfin sodium-mediated photodynamic therapy for esophageal squamous cell carcinoma.

Ohashi S, Kikuchi O, Tsurumaki M, Nakai Y, Kasai H, Horimatsu T, Miyamoto S, Shimizu A, Chiba T, Muto M

PloS one 9(8) e103126 2014 [Refereed]

Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations.

Kiso H, Takahashi K, Saito K, Togo Y, Tsukamoto H, Huang B, Sugai M, Shimizu A, Tabata Y, Economides AN, Slavkin HC, Bessho K

PloS one 9(5) e96938 2014 [Refereed]

Clinical effects of ghrelin on gastrointestinal involvement in patients with systemic sclerosis.

Ariyasu H, Iwakura H, Yukawa N, Murayama T, Yokode M, Tada H, Yoshimura K, Teramukai S, Ito T, Shimizu A, Yonezawa A, Kangawa K, Mimori T, Akamizu T

Endocrine journal 61(7) 735-742 2014 [Refereed]

Novel collagen/gelatin scaffold with sustained release of basic fibroblast growth factor: clinical trial for chronic skin ulcers.

Morimoto N, Yoshimura K, Niimi M, Ito T, Aya R, Fujitaka J, Tada H, Teramukai S, Murayama T, Toyooka C, Miura K, Takemoto S, Kanda N, Kawai K, Yokode M, Shimizu A, Suzuki S

Tissue engineering. Part A 19(17-18) 1931-1940 Sep 2013 [Refereed]

Evasion from accelerated blood clearance of nanocarrier named as "lactosome" induced by excessive administration of Lactosome

E. Hara; A. Makino; K. Kurihara; M. Sugai; A. Shimizu; I. Hara; E. Ozeki; S. Kimura

Biochimica et Biophysica Acta - General Subjects 1830(8) 4046-4052 Aug 2013 [Refereed]

Comparison of the indocyanine green fluorescence and blue dye methods in detection of sentinel lymph nodes in early-stage breast cancer

T. Sugie; T. Sawada; N. Tagaya; T. Kinoshita; K. Yamagami; H. Suwa; T. Ikeda; K. Yoshimura; M. Niimi; A. Shimizu; M. Toi

Annals of Surgical Oncology 20(7) 2213-2218 Jul 2013 [Refereed]

Phenotypes of CCAAT/enhancer-binding protein beta deficiency: Hyperdontia and elongated coronoid process

B. Huang; K. Takahashi; T. Sakata-Goto; H. Kiso; Y. Togo; K. Saito; H. Tsukamoto; M. Sugai; S. Akira; A. Shimizu; K. Bessho

Oral Diseases 19(2) 144-150 2013 [Refereed]

Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis

T. Sakata-Goto; K. Takahashi; H. Kiso; B. Huang; H. Tsukamoto; M. Takemoto; T. Hayashi; M. Sugai; T. Nakamura; Y. Yokota; A. Shimizu; H. Slavkin; K. Bessho

Bone 50(1) 69-78 Jan 2012 [Refereed]

In situ differentiation of CD8α αt cells from CD4 T cells in peripheral lymphoid tissues

Y. Nambu; T. Hayashi; K.-J. Jang; K. Aoki; H. Mano; K. Nakano; M. Osato; K. Takahashi; K. Itoh; S. Teramukai; T. Komori; J. Fujita; Y. Ito; A. Shimizu; M. Sugai

Scientific Reports 2 2012 [Refereed]

An exploratory clinical trial for combination wound therapy with a novel medical matrix and fibroblast growth factor in patients with chronic skin ulcers: A study protocol

N. Morimoto; K. Yoshimura; M. Niimi; T. Ito; H. Tada; S. Teramukai; T. Murayama; C. Toyooka; S. Takemoto; K. Kawai; M. Yokode; A. Shimizu; S. Suzuki

American Journal of Translational Research 4(1) 52-59 2012 [Refereed]

Increased risk of temporomandibular joint closed lock: A case-control study of ANKH polymorphisms

B. Huang; K. Takahashi; T. Sakata; H. Kiso; M. Sugai; K. Fujimura; A. Shimizu; S. Kosugi; T. Sato; K. Bessho

PLoS ONE 6(10) Oct 2011 [Refereed]

A novel synthetic material for spinal fusion: A prospective clinical trial of porous bioactive titanium metal for lumbar interbody fusion

S. Fujibayashi; M. Takemoto; M. Neo; T. Matsushita; T. Kokubo; K. Doi; T. Ito; A. Shimizu; T. Nakamura

European Spine Journal 20(9) 1486-1495 Sep 2011 [Refereed]

Runx3 is required for full activation of regulatory T cells to prevent colitis-associated tumor formation

M. Sugai; K. Aoki; M. Osato; Y. Nambu; K. Ito; M.M. Taketo; A. Shimizu

Journal of Immunology 186(11) 6515-6520 Jun 2011 [Refereed]

Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: A phase I/II clinical trial, following preclinical studies to ensure safety

A. Ido; A. Moriuchi; M. Numata; T. Murayama; S. Teramukai; H. Marusawa; N. Yamaji; H. Setoyama; I. Kim; T. Chiba; S. Higuchi; M. Yokode; M. Fukushima; A. Shimizu; H. Tsubouchi

Journal of Translational Medicine 9 May 2011 [Refereed]

Cross-priming of CD8⁺ T cells in vivo by dendritic cells pulsed with autologous apoptotic leukemic cells in immunotherapy for elderly patients with acute myeloid leukemia

T. Kitawaki; N. Kadowaki; K. Fukunaga; Y. Kasai; T. Maekawa; K. Ohmori; T. Itoh; A. Shimizu; K. Kuzushima; T. Kondo; T. Ishikawa; T. Uchiyama

Experimental Hematology 39(4) 424-433 Apr 2011 [Refereed]

Functions of Runx in IgA class switch recombination

M. Sugai; K. Watanabe; Y. Nambu; T. Hayashi; A. Shimizu

Journal of Cellular Biochemistry 112(2) 409-414 2011 [Refereed]

Graded attenuation of TCR Signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function

S. Tanaka; S. Maeda; M. Hashimoto; C. Fujimori; Y. Ito; S. Teradaira; K. Hirota; H. Yoshitomi; T. Katakai; A. Shimizu; T. Nomura; N. Sakaguchi; S. Sakaguchi

Journal of Immunology 185(4) 2295-2305 Aug 2010 [Refereed]

Requirement for Runx proteins in IgA class switching acting downstream of TGF-β1 and retinoic acid signaling

K. Watanabe; M. Sugai; Y. Nambu; M. Osato; T. Hayashi; M. Kawaguchi; T. Komori; Y. Ito; A. Shimizu

Journal of Immunology 184(6) 2785-2792 Mar 2010 [Refereed]

CXCL13 production by an established lymph node stromal cell line via lymphotoxin-beta receptor engagement involves the cooperation of multiple signaling pathways

H. Suto; T. Katakai; M. Sugai; T. Kinashi; A. Shimizu

International Immunology 21(4) 467-476 Apr 2009 [Refereed]

UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients

M. Onoue; T. Terada; M. Kobayashi; T. Katsura; S. Matsumoto; K. Yanagihara; T. Nishimura; M. Kanai; S. Teramukai; A. Shimizu; M. Fukushima; K.-I. Inui

International Journal of Clinical Oncology 14(2) 136-142 Apr 2009 [Refereed]

Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs

T. Katakai; H. Suto; M. Sugai; H. Gonda; A. Togawa; S. Suematsu; Y. Ebisuno; K. Katagiri; T. Kinashi; A. Shimizu

Journal of Immunology 181(9) 6189-6200 Nov 2008 [Refereed]

Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse

A. Murashima-Suginami; K. Takahashi; T. Sakata; H. Tsukamoto; M. Sugai; M. Yanagita; A. Shimizu; T. Sakurai; H.C. Slavkin; K. Bessho

Biochemical and Biophysical Research Communications 369(4) 1012-1016 May 2008 [Refereed]

Repeated administration of ghrelin to patients with functional dyspepsia: Its effects on food intake and appetite

T. Akamizu; H. Iwakura; H. Ariyasu; H. Hosoda; T. Murayama; M. Yokode; S. Teramukai; H. Seno; T. Chiba; S. Noma; Y. Nakai; M. Fukunaga; Y. Nakai; K. Kangawa; T. Irako; H. Tada; I. Bando; K. Miura; A. Matsuyama; A. Shimizu; M. Fukushima; K. Shide; Y. Tamai; N. Watanabe; H. Nakase; T. Abe; T. Shinomiya; A. Fukao; M. Suda

European Journal of Endocrinology 158(4) 491-498 Apr 2008 [Refereed]

Undesired meeting of lymphocytes: Organ-specific infiltration and the organization of ectopic lymphoid tissue in a murine experimental autoimmune gastritis

T. Katakai; A. Shimizu

Immunology Letters 118(2) 103-109 2008 [Refereed]

IL-21 induces inhibitor of differentiation 2 and leads to complete abrogation of anaphylaxis in mice

T. Kishida; Y. Hiromura; M. Shin-Ya; H. Asada; H. Kuriyama; M. Sugai; A. Shimizu; Y. Yokota; T. Hama; J. Imanishi; Y. Hisa; O. Mazda

Journal of Immunology 179(12) 8554-8561 Dec 2007 [Refereed]

Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation

A. Murashima-Suginami; K. Takahashi; T. Kawabata; T. Sakata; H. Tsukamoto; M. Sugai; M. Yanagita; A. Shimizu; T. Sakurai; H.C. Slavkin; K. Bessho

Biochemical and Biophysical Research Communications 359(3) 549-555 Aug 2007 [Refereed]

The network of fibroblastic reticular cells in the lymph node: Functional framework for immune surveillance

T. Katakai; A. Shimizu

Current Immunology Reviews 3(4) 251-257 2007 [Refereed]

Spontaneous large-scale lymphoid neogenesis and balanced autoimmunity versus tolerance in the stomach of H⁺/K⁺-ATPase-reactive TCR transgenic mouse

T. Katakai; T. Nomura; H. Gonda; M. Sugai; Y. Agata; A. Nishio; T. Masuda; S. Sakaguchi; A. Shimizu

Journal of Immunology 177(11) 7858-7867 Dec 2006 [Refereed]

Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3′-UTRs

T. Kubo; T. Wada; Y. Yamaguchi; A. Shimizu; H. Handa

Nucleic Acids Research 34(21) 6264-6271 Dec 2006 [Refereed]

A transmembrane chemokine, CXC chemokine ligand 16, expressed by lymph node fibroblastic reticular cells has the potential to regulate T cell migration and adhesion

T. Hara; T. Katakai; J.-H. Lee; Y. Nambu; N. Nakajima-Nagata; H. Gonda; M. Sugai; A. Shimizu

International Immunology 18(2) 301-311 Feb 2006 [Refereed]

Plasma ghrelin levels in healthy elderly volunteers: The levels acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure

T. Akamizu; T. Murayama; S. Teramukai; K. Miura; I. Bando; T. Irako; H. Iwakura; H. Ariyasu; H. Hosoda; H. Tada; A. Matsuyama; S. Kojima; T. Wada; Y. Wakatsuki; K. Matsubayashi; T. Kawakita; A. Shimizu; M. Fukushima; M. Yokode; K. Kangawa

Journal of Endocrinology 188(2) 333-344 Feb 2006 [Refereed]

Choroid plexus ependymal cells host neural progenitor cells in the rat

Y. Itokazu; M. Kitada; M. Dezawa; A. Mizoguchi; N. Matsumoto; A. Shimizu; C. Ide

GLIA 53(1) 32-42 Jan 2006 [Refereed]

Enhanced anti-fibrotic activity of plasmid DNA expressing small interference RNA for TGF-β type II receptor for a mouse model of obstructive nephropathy by cationized gelatin prepared from different amine compounds

T. Kushibiki; N. Nagata-Nakajima; M. Sugai; A. Shimizu; Y. Tabata

Journal of Controlled Release 110(3) 610-617 2006 [Refereed]

Polymorphisms in PTCH1 affect the risk of ameloblastoma

T. Kawabata; K. Takahashi; M. Sugai; A. Murashima-Suginami; S. Ando; A. Shimizu; S. Kosugi; T. Sato; M. Nishida; K. Murakami; T. Iizuka

Journal of Dental Research 84(9) 812-816 Sep 2005 [Refereed]

Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves\\' disease

H. Hiratani; D.W. Bowden; S. Ikegami; S. Shirasawa; A. Shimizu; Y. Iwatani; T. Akamizu

Journal of Clinical Endocrinology and Metabolism 90(5) 2898-2903 May 2005 [Refereed]

CpG inhibits IgE class switch recombination through suppression of NFκB activity, but not through Id2 or Bcl6

T. Kusunoki; M. Sugai; H. Gonda; Y. Nambu; N. Nagata-Nakajima; T. Katakai; M. Kusunoki; A. Sakamoto; T. Tokuhisa; T. Nakahata; Y. Yokota; A. Shimizu

Biochemical and Biophysical Research Communications 328(2) 499-506 Mar 2005 [Refereed]

SPINK5 polymorphism is associated with disease severity and food allergy in children with atopic dermatitis [5]

T. Kusunoki; I. Okafuji; T. Yoshioka; M. Saito; R. Nishikomori; T. Heike; M. Sugai; A. Shimizu; T. Nakahata

Journal of Allergy and Clinical Immunology 115(3) 636-638 Mar 2005 [Refereed]

Delivery of plasmid DNA expressing small interference RNA for TGF-β type II receptor by cationized gelatin to prevent interstitial renal fibrosis

T. Kushibiki; N. Nagata-Nakajima; M. Sugai; A. Shimizu; Y. Tabata

Journal of Controlled Release 105(3) 318-331 2005 [Refereed]

Targeting of plasmid DNA to renal interstitial fibroblasts by cationized gelatin

T. Kushibiki; N. Nagata-Nakajima; M. Sugai; A. Shimizu; Y. Tabata

Biological and Pharmaceutical Bulletin 28(10) 2007-2010 2005 [Refereed]

Delivery of small interference RNA to renal interstitial fibroblasts by cationized gelatin

T. Kushibiki; N. Nakajima-Nagata; M. Sugai; A. Shimizu; Y. Tabata

Polymer Preprints, Japan 54(1) 2143- 2005 [Refereed]

Roles of p-ERM and Rho-ROCK signalling in lymphocyte polarity and uropod formation

J.-H. Lee; T. Katakai; T. Hara; H. Gonda; M. Sugai; A. Shimizu

Journal of Cell Biology 167(2) 327-337 Oct 2004 [Refereed]

Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes

T. Katakai; T. Hara; M. Sugai; H. Gonda; A. Shimizu

Journal of Experimental Medicine 200(6) 783-795 Sep 2004 [Refereed]

Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects

T. Akamizu; K. Takaya; T. Irako; H. Hosoda; S. Teramukai; A. Matsuyama; H. Tada; K. Miura; A. Shimizu; M. Fukushima; M. Yokode; K. Tanaka; K. Kangawa

European Journal of Endocrinology 150(4) 447-455 Apr 2004 [Refereed]

Pdx-1 enables insulin secretion by regulating synaptotagmin 1 gene expression

N. Nakajima-Nagata; M. Sugai; T. Sakurai; J.-I. Miyazaki; Y. Tabata; A. Shimizu

Biochemical and Biophysical Research Communications 318(3) 631-635 2004 [Refereed]

In vitro induction of adult hepatic progenitor cells into insulin-producing cells

N. Nakajima-Nagata; T. Sakurai; T. Mitaka; T. Katakai; E. Yamato; J.-I. Miyazaki; Y. Tabata; M. Sugai; A. Shimizu

Biochemical and Biophysical Research Communications 318(3) 625-630 2004 [Refereed]

Characterization of V_Hε gene expressed in PBL from children with atopic diseases: Detection of homologous V_H1-69 derived transcripts from three unrelated patients

Y. Bando; A. Shimizu; C. Ra

Immunology Letters 94(1-2) 99-106 2004 [Refereed]

A novel reticular stromal structure in lymph node cortex: An immuno-platform for interactions among dendritic cells, T cells and B cells

T. Katakai; T. Hara; J.-H. Lee; H. Gonda; M. Sugai; A. Shimizu

International Immunology 16(8) 1133-1142 2004 [Refereed]

Role of Id proteins in B lymphocyte activation: New insights from knockout mouse studies

M. Sugai; H. Gonda; Y. Nambu; Y. Yokota; A. Shimizu

Journal of Molecular Medicine 82(9) 592-599 2004 [Refereed]

Chemokines and autoimmune diseases

T. Katakai; A. Shimizu

Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents 3(4) 341-350 2004 [Refereed]

Transcription-Coupled Events Associating with Immunoglobulin Switch Region Chromatin

Y. Nambu; M. Sugai; H. Gonda; C.-G. Lee; T. Katakai; Y. Agata; Y. Yokota; A. Shimizu

Science 302(5653) 2137-2140 Dec 2003 [Refereed]

Essential role of Id2 in negative regulation of IgE class switching

M. Sugai; H. Gonda; T. Kusunoki; T. Katakai; Y. Yokota; A. Shimizu

Nature Immunology 4(1) 25-30 Jan 2003 [Refereed]

T_H2 dominance and defective development of a CD8⁺ dendritic cell subset in Id2-deficient mice

T. Kusunoki; M. Sugai; T. Katakai; Y. Omatsu; T. Iyoda; K. Inaba; T. Nakahata; A. Shimizu; Y. Yokota

Journal of Allergy and Clinical Immunology 111(1) 136-142 Jan 2003 [Refereed]

The Balance Between Pax5 and Id2 Activities Is the Key to AID Gene Expression

H. Gonda; M. Sugai; Y. Nambu; T. Katakai; Y. Agata; K.J. Mori; Y. Yokota; A. Shimizu

Journal of Experimental Medicine 198(9) 1427-1437 2003 [Refereed]

Th1-biased tertiary lymphoid tissue supported by CXC chemokine ligand 13-producing stromal network in chronic lesions of autoimmune gastritis

T. Katakai; T. Hara; M. Sugai; H. Gonda; A. Shimizu

Journal of Immunology 171(8) 4359-4368 2003 [Refereed]

Selective accumulation of type 1 effector cells expressing P-selectin ligand and/or α₄β₇-integrin at the lesions of autoimmune gastritis

T. Katakai; K.J. Mori; T. Masuda; A. Shimizu

International Immunology 14(2) 167-175 2002 [Refereed]

Chemokine-independent preference for T-helper-1 cells in transendothelial migration

T. Katakai; T. Hara; M. Sugai; H. Gonda; Y. Nambu; E. Matsuda; Y. Agata; A. Shimizu

Journal of Biological Chemistry 277(52) 50948-50958 2002 [Refereed]

Effect of environmental antigens on the Ig diversification and the selection of productive V-J joints in the bursa

H. Arakawa; K.-I. Kuma; M. Yasuda; S. Ekino; A. Shimizu; H. Yamagishi

Journal of Immunology 169(2) 818-828 2002 [Refereed]

Targeting of Krüppel-associated box-containing zinc finger proteins to centromeric heterochromatin. Implication for the gene silencing mechanisms

E. Matsuda; Y. Agata; M. Sugai; T. Katakai; H. Gonda; A. Shimizu

Journal of Biological Chemistry 276(17) 14222-14229 Apr 2001 [Refereed]

Histone acetylation determines the developmentally regulated accessibility for T cell receptor γ gene recombination

Y. Agata; T. Katakai; S.-K. Ye; M. Sugai; H. Gonda; T. Honjo; K. Ikuta; A. Shimizu

Journal of Experimental Medicine 193(7) 873-879 Apr 2001 [Refereed]

DNA polymerase β is not essential for the formation of palindromic (P) region of T cell receptor gene

H. Gonda; M. Sugai; T. Katakai; N. Sugo; Y. Aratani; H. Koyama; K.J. Mori; A. Shimizu

Immunology Letters 78(1) 45-49 2001 [Refereed]

The IL-7 receptor controls the accessibility of the TCRγ locus by Stat5 and histone acetylation

S.-K. Ye; Y. Agata; H.-C. Lee; H. Kurooka; T. Kitamura; A. Shimizu; T. Honjo; K. Ikuta

Immunity 15(5) 813-823 2001 [Refereed]

Class switch recombination of the chicken IgH chain genes: Implications for the primordial switch region repeats

H. Kitao; H. Arakawa; K.-I. Kuma; H. Yamagishi; N. Nakamura; S. Furusawa; H. Matsuda; M. Yasuda; S. Ekino; A. Shimizu

International Immunology 12(7) 959-968 2000 [Refereed]

The helix-loop-helix inhibitor Id2 and cell differentiation control

Y. Yokota; S. Mori; S.-I. Nishikawa; A. Mansouri; P. Gruss; T. Kusunoki; T. Katakai; A. Shimizu

Current Topics in Microbiology and Immunology 251 35-41 2000 [Refereed]

Molecular and clinical features of non-Burkitt\ś, diffuse large-cell lymphoma of B-cell type associated with the e-MYC/immunoglobulin heavy-chain fusion gene

T. Akasaka; H. Akasaka; C. Ueda; N. Yonetani; Y. Maesako; A. Shimizu; H. Yamabe; S. Fukuhara; T. Uchiyama; H. Ohno

Journal of Clinical Oncology 18(3) 510-518 2000 [Refereed]

Molecular anatomy of BCL6 translocations revealed by long-distance polymerase chain reaction-based assays

H. Akasaka; T. Akasaka; M. Kurata; C. Ueda; A. Shimizu; T. Uchiyama; H. Ohno

Cancer Research 60(9) 2335-2341 2000 [Refereed]

Two novel Kruppel-associated box-containing zinc-finger proteins, KRAZ1 and KRAZ2, repress transcription through functional interaction with the corepressor KAP-1 (TIF1 β/KRIP-1)

Y. Agata; E. Matsuda; A. Shimizu

Journal of Biological Chemistry 274(23) 16412-16422 Jun 1999 [Refereed]

Molecular cloning and splicing isoforms of mouse p144, a homologue of CA150

M. Shimada; M. Saito; T. Katakai; A. Shimizu; T. Ichimura; S. Omata; T. Horigome

Journal of Biochemistry 126(6) 1033-1042 1999 [Refereed]

Isolation of differentially expressed genes upon immunoglobulin class switching by a subtractive hybridization method using uracil DNA glycosylase

M. Sugai; S. Kondo; A. Shimizu; T. Honjo

Nucleic Acids Research 26(4) 911-918 Feb 1998 [Refereed]

Differential localization of T(h)1 and T(h)2 cells in autoimmune gastritis

T. Katakai; K.J. Mori; T. Masuda; A. Shimizu

International Immunology 10(9) 1325-1334 1998 [Refereed]

Rapid and efficient cloning of cDNAs encoding Kruppel-like zinc finger proteins by degenerate PCR

Y. Agata; E. Matsuda; A. Shimizu

Gene 213(1-2) 55-64 1998 [Refereed]

Structure of the TCR expressed on a gastritogenic T cell clone, IL-6, and frequent appearance of similar clonotypes in mice bearing autoimmune gastritis

T. Katakai; Y. Agata; A. Shimizu; C. Ohshima; A. Nishio; M. Inaba; S. Kasakura; K.J. Mori; T. Masuda

International Immunology 9(12) 1849-1855 Dec 1997 [Refereed]

Chicken immunoglobulin μ-chain gene: Germline organization and tandem repeats characteristic of class switch recombination

H. Kitao; H. Arakawa; H. Yamagishi; A. Shimizu

Immunology Letters 52(2-3) 99-104 1996 [Refereed]

Transforming growth factor-β induced class switch recombination may be modified during the cell proliferation restored by IL-2 stimulation

T. Iwasato; Y. Kanari; A. Shimizu; T. Honjo; H. Yamagishi

Immunology Letters 39(2) 173-178 1994 [Refereed]

Synthesis and regulation of trans-mRNA encoding the immunoglobulin ∈ heavy chain

A. Shimizu; T. Honjo

FASEB Journal 7(1) 149-154 Jan 1993 [Refereed]

Isolation of cDNA encoding a binding protein specific to 5′-phosphorylated single-stranded DNA with G-rich sequences

T.-R. Mizuta; Y. Fukita; T. Miyoshi; A. Shimizu; T. Honjo

Nucleic Acids Research 21(8) 1761-1766 1993 [Refereed]

The human Sμbp-2, a DNA-binding protein specific to the single-stranded guanine-rich sequence related to the immunoglobulin μ chain switch region

Y. Fukita; T.-R. Mizuta; M. Shirozu; K. Ozawa; A. Shimizu; T. Honjo

Journal of Biological Chemistry 268(23) 17463-17470 1993 [Refereed]

The complete murine immunoglobulin class switch region of the α heavy chain gene-hierarchic repetitive structure and recombination breakpoints

H. Arakawa; T. Iwasato; H. Hayashida; A. Shimizu; T. Honjo; H. Yamagishi

Journal of Biological Chemistry 268(7) 4651-4655 1993 [Refereed]

Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice

M. Murakami; T. Tsubata; M. Okamoto; A. Shimizu; S. Kumagai; H. Imura; T. Honjo

Nature 357(6373) 77-80 May 1992 [Refereed]

A transgenic model of autoimmune hemolytic anemia

M. Okamoto; M. Murakami; A. Shimizu; S. Ozaki; T. Tsubata; S.-I. Kumagai; T. Honjo

Journal of Experimental Medicine 175(1) 71-79 1992 [Refereed]

Mapping of the nu gene using congenic nude strains and in situ hybridization

Y. Takahashi; A. Shimizu; T. Sakai; Y.-I. Endo; N. Osawa; H. Shisa; T. Honjo

Journal of Experimental Medicine 175(3) 873-876 1992 [Refereed]

Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor β and lipopolysaccharide

T. Iwasato; H. Arakawa; A. Shimizu; T. Honjo; H. Yamagishi

Journal of Experimental Medicine 175(6) 1539-1546 1992 [Refereed]

Misc

Plain Text

Delivery of small interference RNA of transforming \ngrowth factor beta 1 receptor by cationized gelatin.

Kushibiki, T., Nagata-Nakajima, N., Sugai, M., Shimizu, A., Tabata, Y.

4th Asian International Symposium on Biomaterials （AISB4）and 2nd International Symposium on Fusion of Nano and Bio Technologies（FNB）（2004.11.16－18. Tsukuba） Nov 2004 [Refereed]

Spontaneous lymphoid neogenesis and balanced autoimmunity versus tolerance in the stomach of H+/K+-ATPase-reactive TCR transgenic mouse.

Tomoya Katakai, Takashi Nomura, Hiroyuki Gonda, Manabu Sugai, Shimon Sakaguchi, Akira Shimizu.

第36 回日本免疫学会総会（2006.12.11－13. 大阪） Dec 2006 [Refereed]

Association Memberships

The Japanese Biochmical Society(1) , The Molecular Biology Society of Japan(2658) , Japanese Society for Immunology(228) , The American Society for Biochemistry and Molecular Biology(22)

Research Grants & Projects

Plain Text

Gene sturucture and expression in immune system

Basic Research Promotion Service for Health and Medical Field

Gene reguation in immune system to control allergy and autoimmne diseases