2008年5月
Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- 巻
- 369
- 号
- 4
- 開始ページ
- 1012
- 終了ページ
- 1016
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bbrc.2008.02.135
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Uterine sensitization associated gene-1 (USAG-1) is a BMP antagonist, and also modulates Wnt signaling. We previously reported that USAG-1 deficient mice have supernumerary teeth. The supernumerary maxillary incisor appears to form as a result of the successive development of the rudimentary upper incisor. USAG-1 abrogation rescued apoptotic elimination of odontogenic mesenchymal cells. We confirmed that BMPs were expressed in both the epithelium and mesenchyme of the rudimentary incisor at E14 and E15. BMP signaling in the rudimentary maxillary incisor, assessed by expressions of Msx1 and Dlx2 and the phosphorylation of Smad protein, was significantly enhanced. Wnt signaling as demonstrated by the nuclear localization of P-catenin was also up-regulated. Inhibition of BMP signaling rescues supernumerary tooth formation in E15 incisor explant culture. Based upon these results, we conclude that enhanced BMP signaling results in supernumerary teeth and BNIP signaling was modulated by Wnt signaling in the USAG-1 deficient mouse model. (C) 2008 Elsevier Inc. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.bbrc.2008.02.135
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200902292486302464
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/18329379
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000254864700005&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.bbrc.2008.02.135
- ISSN : 0006-291X
- eISSN : 1090-2104
- J-Global ID : 200902292486302464
- PubMed ID : 18329379
- Web of Science ID : WOS:000254864700005