Akira Shimizu - My portal

Profile Information

Affiliation: Professor, Hospital, Translational Research Center, Department of Experimantal Therapeutics, Kyoto University

Degree: Ph D(Osaka University)

J-GLOBAL ID: 200901047073361693
researchmap Member ID: 5000025578

Research Interests

Research Areas

Research History

1992 - 2003

京都大学遺伝子実験施設教授
1992 - 2003

Professor,
2003

-京都大学医学研究科附属ゲノム医学センター教授
2003

- Professor, Center for Genomic Medicine,
2001

-京都大学医学部附属病院教授
2001

- Professor, Translational Reserach Center,
1987 - 1992

京都大学遺伝子実験施設助教授
1987 - 1992

Associate Professor,
1986 - 1987

Harvard Medical School 研究員
1986 - 1987

Research Fellow, Harvard Medical School
1984 - 1987

Faculty of Medicine, Kyoto University
1984 - 1987

Assistant Professor,
1987

Faculty of Medicine, Kyoto University
1987

Lecturer,
1983 - 1984

Faculty of Medicine, Osaka University
1983 - 1984

Assistant Professor,
Graduate School of Medicine, Kyoto University
Kyoto University Hospital
Kyoto University
Center for Molecular Biology and Genetics,

Education

- 1983

Osaka University
- 1983

Genetics, Graduate School, Division of Medicine, Osaka University
- 1979

School of Medicine, Faculty of Medicine, The University of Tokyo
- 1979

Medicine, Faculty of Medicine, The University of Tokyo

Committee Memberships

Awards

1991

日本生化学会奨励賞

Papers

138

Loss of Stemness, EMT, and Supernumerary Tooth Formation in Cebpb -/- Runx2 +/- Murine Incisors

Kazuyuki Saito, Katsu Takahashi, Boyen Huang, Masakazu Asahara, Honoka Kiso, Yumiko Togo, Hiroko Tsukamoto, Sayaka Mishima, Masaki Nagata, Machiko Iida …

Scientific Reports, 8(1) 5169, Dec 1, 2018 Peer-reviewed
Direct evidence for the age-dependent demise of GNAS-mutated cells in oral fibrous dysplasia

Yu Isobe, Katsu Takahashi, Honoka Kiso, Kazumasa Nakao, Masayuki Ikeno, Noriaki Koyama, Manabu Sugai, Akira Shimizu, Hironori Haga, Kazuhisa Bessho

Archives of Oral Biology, 93 133-140, Sep 1, 2018 Peer-reviewed
A therapeutic angiogenesis of sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel sheets in a canine chronic myocardial infarction mode

Kumagai, M, Minakata, K, Masumoto, H, Yamamoto, M, Yonezawa, A, Ikeda, T, Uehara, K, Yamazaki, K, Ikeda, T, Matsubara, K …

Heart and Vessels, 33(10) 2151-2157, May, 2018 Peer-reviewed
Patterns of clinical practice for sentinel lymph node biopsy in women with node-negative breast cancer: the results of a national survey in Japan

Takafumi Ikeda, Tomoharu Sugie, Akira Shimizu, Masakazu Toi

BREAST CANCER, 24(2) 341-344, Mar, 2017 Peer-reviewed
Sentinel lymph node biopsy using indocyanine green fluorescence in early-stage breast cancer: a meta-analysis

Tomoharu Sugie, Takafumi Ikeda, Atsushi Kawaguchi, Akira Shimizu, Masakazu Toi

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 22(1) 11-17, Feb, 2017 Peer-reviewed
Transcutaneous oxygen pressure as a surrogate Index of lower limb amputation

Hiroomi Nishio, Kenji Minakata, Atsushi Kawaguchi, Motoyuki Kumagai, Takafumi Ikeda, Akira Shimizu, Masayuki Yokode, Satoshi Morita, Ryuzo Sakata

INTERNATIONAL ANGIOLOGY, 35(6) 565-572, Dec, 2016 Peer-reviewed
Prognostic impact of salvage treatment on hearing recovery in patients with sudden sensorineural hearing loss refractory to systemic corticosteroids: A retrospective observational study

Takayuki Nakagawa, Michio Yamamoto, Kozo Kumakawa, Shin-ichi Usami, Naohito Hato, Keiji Tabuchi, Mariko Takahashi, Keizo Fujiwara, Akira Sasaki, Shizuo Komune …

AURIS NASUS LARYNX, 43(5) 489-494, Oct, 2016 Peer-reviewed
A pilot study of regenerative therapy using controlled release of recombinant human fibroblast growth factor for patients with pre-collapse osteonecrosis of the femoral head

Yutaka Kuroda, Ryuta Asada, Kazutaka So, Atsushi Yonezawa, Manabu Nankaku, Kumi Mukai, Toshiko Ito-Ihara, Harue Tada, Michio Yamamoto, Toshinori Murayama …

INTERNATIONAL ORTHOPAEDICS, 40(8) 1747-1754, Aug, 2016 Peer-reviewed
Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.

Yuki Sato, Akiko Mii, Yoko Hamazaki, Harumi Fujita, Hirosuke Nakata, Kyoko Masuda, Shingo Nishiyama, Shinsuke Shibuya, Hironori Haga, Osamu Ogawa …

JCI insight, 1(11) e87680, Jul 21, 2016 Peer-reviewed
Effects of Usag-1 and Bmp7 deficiencies on murine tooth morphogenesis

Kazuyuki Saito, Katsu Takahashi, Masakazu Asahara, Honoka Kiso, Yumiko Togo, Hiroko Tsukamoto, Boyen Huang, Manabu Sugai, Akira Shimizu, Masaharu Motokawa …

BMC DEVELOPMENTAL BIOLOGY, 16 14, May, 2016 Peer-reviewed
Safety and efficacy of sustained release of basic fibroblast growth factor using gelatin hydrogel in patients with critical limb ischemia.

Motoyuki Kumagai, Akira Marui, Yasuhiko Tabata, Takahide Takeda, Masaya Yamamoto, Atsushi Yonezawa, Shiro Tanaka, Shigeki Yanagi, Toshiko Ito-Ihara, Takafumi Ikeda …

Heart and vessels, 31(5) 713-21, May, 2016 Peer-reviewed
Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer

Junzo Hamanishi, Masaki Mandai, Takafumi Ikeda, Manabu Minami, Atsushi Kawaguchi, Toshinori Murayama, Masashi Kanai, Yukiko Mori, Shigemi Matsumoto, Shunsuke Chikuma …

JOURNAL OF CLINICAL ONCOLOGY, 33(34) 4015-+, Dec, 2015 Peer-reviewed
ANKH Polymorphisms and Clicking of the Temporomandibular Joint in Dental Residents.

Boyen Huang, Katsu Takahashi, Tomoko Goto, Honoka Kiso, Manabu Sugai, Akira Shimizu, Shinji Kosugi, Kazuhisa Bessho

Journal of maxillofacial and oral surgery, 14(2) 247-51, Jun, 2015 Peer-reviewed
Activation of B1a Cells in Peritoneal Cavity by T Cell-Independent Antigen Expressed on Polymeric Micelle

Cheol Joo Kim, Eri Hara, Akira Shimizu, Manabu Sugai, Shunsaku Kimura

JOURNAL OF PHARMACEUTICAL SCIENCES, 104(5) 1839-1847, May, 2015 Peer-reviewed
Mitochondrial function provides instructive signals for activation-induced B-cell fates

Kyoung-Jin Jang, Hiroto Mano, Koji Aoki, Tatsunari Hayashi, Akihiko Muto, Yukiko Nambu, Katsu Takahashi, Katsuhiko Itoh, Shigeru Taketani, Stephen L. Nutt …

NATURE COMMUNICATIONS, 6 6750, Apr, 2015 Peer-reviewed
Effects of zoledronic acid and the association between its efficacy and γδT cells in postmenopausal women with breast cancer treated with preoperative hormonal therapy: a study protocol.

Eriko Sumi, Tomoharu Sugie, Kenichi Yoshimura, Harue Tada, Takafumi Ikeda, Eiji Suzuki, Yoshimasa Tanaka, Satoshi Teramukai, Akira Shimizu, Masakazu Toi …

Journal of translational medicine, 12 310-310, Nov 25, 2014 Peer-reviewed
A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment

Takayuki Nakagawa, Kozo Kumakawa, Shin-ichi Usami, Naohito Hato, Keiji Tabuchi, Mariko Takahashi, Keizo Fujiwara, Akira Sasaki, Shizuo Komune, Tatsunori Sakamoto …

BMC MEDICINE, 12 219, Nov, 2014 Peer-reviewed
Preclinical Validation of Talaporfin Sodium-Mediated Photodynamic Therapy for Esophageal Squamous Cell Carcinoma

Shinya Ohashi, Osamu Kikuchi, Mihoko Tsurumaki, Yukie Nakai, Hiroi Kasai, Takahiro Horimatsu, Shin'ichi Miyamoto, Akira Shimizu, Tsutomu Chiba, Manabu Muto

PLOS ONE, 9(8) e103126, Aug, 2014 Peer-reviewed
Clinical effects of ghrelin on gastrointestinal involvement in patients with systemic sclerosis

Hiroyuki Ariyasu, Hiroshi Iwakura, Naoichiro Yukawa, Toshinori Murayama, Masayuki Yokode, Harue Tada, Kenichi Yoshimura, Satoshi Teramukai, Tatsuya Ito, Akira Shimizu …

ENDOCRINE JOURNAL, 61(7) 735-742, Jul, 2014 Peer-reviewed
Interactions between BMP-7 and USAG-1 (Uterine Sensitization-Associated Gene-1) Regulate Supernumerary Organ Formations

Honoka Kiso, Katsu Takahashi, Kazuyuki Saito, Yumiko Togo, Hiroko Tsukamoto, Boyen Huang, Manabu Sugai, Akira Shimizu, Yasuhiko Tabata, Aris N. Economides …

PLOS ONE, 9(5) e96938, May, 2014 Peer-reviewed

Misc.

Spontaneous lymphoid neogenesis and balanced autoimmunity versus tolerance in the stomach of H+/K+-ATPase-reactive TCR transgenic mouse.

Tomoya Katakai, Takashi Nomura, Hiroyuki Gonda, Manabu Sugai, Shimon Sakaguchi, Akira Shimizu

第36 回日本免疫学会総会（2006.12.11－13. 大阪）, Dec 11, 2006 Peer-reviewed
分化抑制因子Id2 によるB 細胞最終分化抑制機構の解析

中島(長田, 奈津紀, 權田裕之, 田畑泰彦, 横田義史, 清水章, 菅井学

第28 回日本分子生物学会年会（2005.12.7-10 福岡）, 2005 Peer-reviewed
カチオン化ゼラチンを用いたsiRNA の腎間質へのデリバリー

櫛引俊宏, 中島奈津紀, 菅井学, 清水章, 田畑泰彦

第54 回高分子学会年次大会（2005.5.25－27 横浜）, 2005 Peer-reviewed
Delivery of small interference RNA of transforming \ngrowth factor beta 1 receptor by cationized gelatin.

Kushibiki, T, Nagata-Nakajima, N, Sugai, M, Shimizu, A, Tabata, Y

4th Asian International Symposium on Biomaterials （AISB4）and 2nd International Symposium on Fusion of Nano and Bio Technologies（FNB）（2004.11.16－18. Tsukuba）, Nov 16, 2004 Peer-reviewed
カチオン化ゼラチンを利用したsiRNA 発現ベクターによる腎線維化進展抑制

櫛引俊宏, 中島奈津紀, 菅井学, 清水章, 田畑泰彦

第20 回日本DDS 学会学術集会（2004.7.15－16. 京都）, 2004 Peer-reviewed

Professional Memberships

Research Projects

アレルギーなど免疫制御に関する基礎研究
免疫系における遺伝子発現の制御機構

保健医療分野における基礎研究推進事業
Gene reguation in immune system to control allergy and autoimmne diseases
Gene sturucture and expression in immune system

Basic Research Promotion Service for Health and Medical Field