OHBA Yusuke

J-GLOBAL         Last updated: Oct 29, 2018 at 08:30
 
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Name
OHBA Yusuke
E-mail
yohbamed.hokudai.ac.jp
URL
http://cp.med.hokudai.ac.jp/en/
Affiliation
Hokkaido University
Section
Graduate School of Medicine Division of Medicine
Job title
Professor
Degree
M.D., Ph.D.(Hokkaido University)

Research Areas

 
 

Academic & Professional Experience

 
Apr 2006
 - 
Oct 2012
Associate Professor, Hokkaido University Graduate School of Medicine
 
Mar 2004
 - 
Mar 2006
Assistant Professor, Graduated School of Medicine, the University of Tokyo
 
Dec 2001
 - 
Mar 2005
Researcher, JST PRESTO
 
Jan 2001
 - 
Mar 2004
Research Associate, Research Institute for Infectious Diseases, Osaka University
 
Apr 1998
 - 
Dec 2000
International Medical Center of Japan Research Institute
 

Education

 
Apr 1996
 - 
Mar 2000
Graduated School of Medicine, Hokkaido University
 
 
 - 
Mar 1996
School of Medicine, Hokkaido University
 

Awards & Honors

 
Jun 2013
FRET-Based Biosensors for Accurate Prediction of Responses to Molecular Target Drugs in Chronic Myeloid Leukemia, German Innovation Award Gottfried Wagner Prize 2013, German Research and Innovation Forum Tokyo/German Chamber of Commerce and Industry in Japan
 

Published Papers

 
Kondo T, Fujioka M, Tsuda M, Murai K, Yamaguchi K, Miyagishima T, Shindo M, Nagashima T, Wakasa K, Fujimoto N, Yamamoto S, Yonezumi M, Saito S, Sato S, Ogawa K, Chou T, Watanabe R, Kato Y, Takahashi S, Okano Y, Yamamoto J, Ohta M, Iijima H, Oba K, Kishino S, Sakamoto J, Ishida Y, Ohba Y, Teshima T, Inter-Michinoku Dasatinib Study Group (IMIDAS).
Cancer science   109(7) 2256-2265   Jul 2018   [Refereed]
Nanbo A, Katano H, Kataoka M, Hoshina S, Sekizuka T, Kuroda M, Ohba Y
Cancers   10(7)    Jul 2018   [Refereed]
Mohamed Z, Hassan MK, Okasha S, Mitamura T, Keshk S, Konno Y, Kato T, El-Khamisy SF, Ohba Y, Watari H
Oncotarget   9(53) 30053-30065   Jul 2018   [Refereed]
Fujioka Y, Nishide S, Ose T, Suzuki T, Kato I, Fukuhara H, Fujioka M, Horiuchi K, Satoh AO, Nepal P, Kashiwagi S, Wang J, Horiguchi M, Sato Y, Paudel S, Nanbo A, Miyazaki T, Hasegawa H, Maenaka K, Ohba Y
Cell host & microbe   23(6) 809-818.e5   Jun 2018   [Refereed]
Kitamura S, Yanagi T, Inamura-Takashima Y, Imafuku K, Hata H, Fujioka Y, Ohba Y, Shimizu H
Journal of dermatological science   90(2) 213-216   May 2018   [Refereed]
Nanbo A, Maruyama J, Imai M, Ujie M, Fujioka Y, Nishide S, Takada A, Ohba Y, Kawaoka Y
PLoS pathogens   14(1) e1006848   Jan 2018   [Refereed]
Nanbo A, Noda T, Ohba Y
Frontiers in microbiology   9 454   2018   [Refereed]
Nanbo A, Ohashi M, Yoshiyama H, Ohba Y
Frontiers in microbiology   9 984   2018   [Refereed]
Kon S, Ishibashi K, Katoh H, Kitamoto S, Shirai T, Tanaka S, Kajita M, Ishikawa S, Yamauchi H, Yako Y, Kamasaki T, Matsumoto T, Watanabe H, Egami R, Sasaki A, Nishikawa A, Kameda I, Maruyama T, Narumi R, Morita T, Sasaki Y, Enoki R, Honma S, Imamura H, Oshima M, Soga T, Miyazaki JI, Duchen MR, Nam JM, Onodera Y, Yoshioka S, Kikuta J, Ishii M, Imajo M, Nishida E, Fujioka Y, Ohba Y, Sato T, Fujita Y
Nature cell biology   19(5) 530-541   May 2017   [Refereed]
Saitoh S, Maruyama T, Yako Y, Kajita M, Fujioka Y, Ohba Y, Kasai N, Sugama N, Kon S, Ishikawa S, Hayashi T, Yamazaki T, Tada M, Fujita Y
Proceedings of the National Academy of Sciences of the United States of America   114(12) E2327-E2336   Mar 2017   [Refereed]
Ibata M, Iwasaki J, Fujioka Y, Nakagawa K, Darmanin S, Onozawa M, Hashimoto D, Ohba Y, Hatakeyama S, Teshima T, Kondo T
Cancer science   108(2) 200-207   Feb 2017   [Refereed]
Horiguchi M, Fujioka M, Kondo T, Fujioka Y, Li X, Horiuchi K, O Satoh A, Nepal P, Nishide S, Nanbo A, Teshima T, Ohba Y
Cell structure and function   42(1) 15-26   Feb 2017   [Refereed]
Fujioka M, Asano Y, Nakada S, Ohba Y
Methods in molecular biology (Clifton, N.J.)   1555 513-534   2017   [Refereed]
Nanbo A, Kachi K, Yoshiyama H, Ohba Y
The Journal of general virology   97(11) 2989-3006   Nov 2016   [Refereed]
Maishi N, Ohba Y, Akiyama K, Ohga N, Hamada J, Nagao-Kitamoto H, Alam MT, Yamamoto K, Kawamoto T, Inoue N, Taketomi A, Shindoh M, Hida Y, Hida K
Scientific reports   6 28039   Jun 2016   [Refereed]
Okumura R, Kurakawa T, Nakano T, Kayama H, Kinoshita M, Motooka D, Gotoh K, Kimura T, Kamiyama N, Kusu T, Ueda Y, Wu H, Iijima H, Barman S, Osawa H, Matsuno H, Nishimura J, Ohba Y, Nakamura S, Iida T, Yamamoto M, Umemoto E, Sano K, Takeda K
Nature   532(7597) 117-121   Apr 2016   [Refereed]
Yamada T, Tsuda M, Wagatsuma T, Fujioka Y, Fujioka M, Satoh AO, Horiuchi K, Nishide S, Nanbo A, Totsuka Y, Haga H, Tanaka S, Shindoh M, Ohba Y
Scientific reports   6 23545   Mar 2016   [Refereed]
Inuzuka T, Fujioka Y, Tsuda M, Fujioka M, Satoh AO, Horiuchi K, Nishide S, Nanbo A, Tanaka S, Ohba Y
Scientific reports   6 21613   Feb 2016   [Refereed]
Yamamoto S, Yako Y, Fujioka Y, Kajita M, Kameyama T, Kon S, Ishikawa S, Ohba Y, Ohno Y, Kihara A, Fujita Y
Molecular biology of the cell   27(3) 491-499   Feb 2016   [Refereed]
Makino Y, Tsuda M, Ohba Y, Nishihara H, Sawa H, Nagashima K, Tanaka S
Cell communication and signaling : CCS   13 35   Jul 2015   [Refereed]
Tsukiyama T, Fukui A, Terai S, Fujioka Y, Shinada K, Takahashi H, Yamaguchi TP, Ohba Y, Hatakeyama S
Molecular and cellular biology   35(11) 2007-2023   Jun 2015   [Refereed]
Matsumoto R, Tsuda M, Wang L, Maishi N, Abe T, Kimura T, Tanino M, Nishihara H, Hida K, Ohba Y, Shinohara N, Nonomura K, Tanaka S
Cancer science   106(6) 709-717   Jun 2015   [Refereed]
[The Ras-PI3K signaling is involved in the regulation of endocytosis and virus internalization].
Fujioka Y, Ohba Y
Seikagaku. The Journal of Japanese Biochemical Society   87(1) 91-100   Feb 2015   [Refereed]
Akiyama K, Maishi N, Ohga N, Hida Y, Ohba Y, Alam MT, Kawamoto T, Ohmura H, Yamada K, Torii C, Shindoh M, Hida K
The American journal of pathology   185(2) 572-580   Feb 2015   [Refereed]
Hassan MK, Watari H, Mitamura T, Mohamed Z, El-Khamisy SF, Ohba Y, Sakuragi N
Oncoscience   2(3) 294-308   2015   [Refereed]
Fujioka Y, Nanbo A, Nishide SY, Ohba Y
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry   31(4) 267-274   2015   [Refereed]
Terada K, Horinouchi T, Fujioka Y, Higashi T, Nepal P, Horiguchi M, Karki S, Hatate C, Hoshi A, Harada T, Mai Y, Ohba Y, Miwa S
The Journal of biological chemistry   289(51) 35283-35295   Dec 2014   [Refereed]
Mahabir R, Tanino M, Elmansuri A, Wang L, Kimura T, Itoh T, Ohba Y, Nishihara H, Shirato H, Tsuda M, Tanaka S
Neuro-oncology   16(5) 671-685   May 2014   [Refereed]
Hassan MK, Watari H, Salah-Eldin AE, Sultan AS, Mohamed Z, Fujioka Y, Ohba Y, Sakuragi N
PLoS One   9(4) e94213   Apr 2014   [Refereed]
Matsuda-Lennikov M, Suizu F, Hirata N, Hashimoto M, Kimura K, Nagamine T, Fujioka Y, Ohba Y, Iwanaga T, Noguchi M
PLoS One   9(1) e79795   Jan 2014   [Refereed]
Hassan M, Watari H, AbuAlmaaty A, Ohba Y, Sakuragi N
BioMed research international   2014 150845   2014   [Refereed]
Negishi H, Matsuki K, Endo N, Sarashina H, Miki S, Matsuda A, Fukazawa K, Taguchi-Atarashi N, Ikushima H, Yanai H, Nishio J, Honda K, Fujioka Y, Ohba Y, Noda T, Taniguchi S, Nishida E, Zhang Y, Chi H, Flavell RA, Taniguchi T
Proceedings of the National Academy of Sciences of the United States of America   110(49) 19884-19889   Dec 2013   [Refereed]
Y. Fujioka, M. Tsuda, A. Nanbo, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki and Y. Ohba
Nat. Commun.   4 2763   Oct 2013   [Refereed]
Inhibition of influenza A virus infection by Galectin-9
T. Hattori, J. Maruyama, Y. Fujioka, Y. Nakayama, Y. Ohba, T. Niki, T. Arikawa, T. Miyazaki, M. Hirashima, and H. Kida
Jpn. J. Vet. Res.   61(1&2) 5-18   May 2013   [Refereed]
Nagai H, Yasuda S, Ohba Y, Fukuda M, Nakamura T
Journal of biochemistry   153(3) 283-288   Mar 2013   [Refereed]
Ohba Y, Fujioka Y, Nakada S, Tsuda M
Progress in molecular biology and translational science   113 313-348   2013   [Refereed]
Arai R, Tsuda M, Watanabe T, Ose T, Obuse C, Maenaka K, Minami A, Ohba Y
European journal of cancer (Oxford, England : 1990)   48(15) 2417-2430   Oct 2012   [Refereed]
Chiba S, Baghdadi M, Akiba H, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Fujioka Y, Ohba Y, Gorman JV, Colgan JD, Hirashima M, Uede T, Takaoka A, Yagita H, Jinushi M
Nature immunology   13(9) 832-842   Sep 2012   [Refereed]
[Visualization of intracellular signaling and its application to assessment of response to molecular target drugs].
Ohba Y, Tsuda M
Seikagaku. The Journal of Japanese Biochemical Society   84(5) 359-365   May 2012   [Refereed]
Usami Y, Hatano T, Imai S, Kubo S, Sato S, Saiki S, Fujioka Y, Ohba Y, Sato F, Funayama M, Eguchi H, Shiba K, Ariga H, Shen J, Hattori N
Neurobiology of disease   43(3) 651-662   Sep 2011   [Refereed]
Ohba Y, Tsuda M
Nihon yakurigaku zasshi. Folia pharmacologica Japonica   138(1) 13-17   Jul 2011   [Refereed]
Yamada T, Tsuda M, Takahashi T, Totsuka Y, Shindoh M, Ohba Y
The American journal of pathology   178(6) 2845-2856   Jun 2011   [Refereed]
Tsushima K, Osawa T, Yanai H, Nakajima A, Takaoka A, Manabe I, Ohba Y, Imai Y, Taniguchi T, Nagai R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology   25(5) 1531-1543   May 2011   [Refereed]
Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, Cheng G, Yamasaki S, Saito T, Ohba Y, Taniguchi T, Takeda K, Hori S, Ivanov II, Umesaki Y, Itoh K, Honda K
Science (New York, N.Y.)   331(6015) 337-341   Jan 2011   [Refereed]
Fujioka Y, Tsuda M, Hattori T, Sasaki J, Sasaki T, Miyazaki T, Ohba Y
PloS one   6(1) e16324   Jan 2011   [Refereed]
Hayakawa S, Shiratori S, Yamato H, Kameyama T, Kitatsuji C, Kashigi F, Goto S, Kameoka S, Fujikura D, Yamada T, Mizutani T, Kazumata M, Sato M, Tanaka J, Asaka M, Ohba Y, Miyazaki T, Imamura M, Takaoka A
Nature immunology   12(1) 37-44   Jan 2011   [Refereed]
Saito Y, Murata-Kamiya N, Hirayama T, Ohba Y, Hatakeyama M
The Journal of experimental medicine   207(10) 2157-2174   Sep 2010   [Refereed]
Mizutani T, Kondo T, Darmanin S, Tsuda M, Tanaka S, Tobiume M, Asaka M, Ohba Y
Clinical cancer research : an official journal of the American Association for Cancer Research   16(15) 3964-3975   Aug 2010   [Refereed]
Tsutsumi K, Fujioka Y, Tsuda M, Kawaguchi H, Ohba Y
Cellular signalling   21(11) 1672-1679   Nov 2009   [Refereed]
Watanabe T, Tsuda M, Tanaka S, Ohba Y, Kawaguchi H, Majima T, Sawa H, Minami A
Molecular cancer research : MCR   7(9) 1582-1592   Sep 2009   [Refereed]
Umeda M, Murata-Kamiya N, Saito Y, Ohba Y, Takahashi M, Hatakeyama M
The Journal of biological chemistry   284(33) 22166-22172   Aug 2009   [Refereed]
Shiba K, Arai T, Sato S, Kubo S, Ohba Y, Mizuno Y, Hattori N
Biochemical and biophysical research communications   383(3) 331-335   Jun 2009   [Refereed]
Inuzuka T, Tsuda M, Kawaguchi H, Ohba Y
Biochemical and biophysical research communications   379(2) 510-513   Feb 2009   [Refereed]
Inuzuka T, Tsuda M, Tanaka S, Kawaguchi H, Higashi Y, Ohba Y
Cancer research   69(4) 1678-1684   Feb 2009   [Refereed]
Tsutsumi K, Tsuda M, Yazawa N, Nakamura H, Ishihara S, Haga H, Yasuda M, Yamazaki R, Shirato H, Kawaguchi H, Nishioka T, Ohba Y
Cell structure and function   34(2) 89-96   2009   [Refereed]
Takeda K, Kinoshita I, Shimizu Y, Ohba Y, Itoh T, Matsuno Y, Shichinohe T, Dosaka-Akita H
BMC cancer   8 328   Nov 2008   [Refereed]
Yamada T, Tsuda M, Ohba Y, Kawaguchi H, Totsuka Y, Shindoh M
Biochemical and biophysical research communications   368(3) 575-581   Apr 2008   [Refereed]
Mizutani T, Tsuji K, Ebihara Y, Taki S, Ohba Y, Taniguchi T, Honda K
Experimental hematology   36 255-264   Mar 2008   [Refereed]
Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA.
Funami K, Sasai M, Ohba Y, Oshiumi H, Seya T, Matsumoto M
Journal of immunology (Baltimore, Md. : 1950)   179 6867-6872   Nov 2007   [Refereed]
Tabu K, Ohba Y, Suzuki T, Makino Y, Kimura T, Ohnishi A, Sakai M, Watanabe T, Tanaka S, Sawa H
Molecular cancer research : MCR   5(10) 1099-1109   Oct 2007   [Refereed]
Fujioka Y, Utsumi M, Ohba Y, Watanabe Y
Plant & cell physiology   48(9) 1243-1253   Sep 2007   [Refereed]
Fukano T, Sawano A, Ohba Y, Matsuda M, Miyawaki A
Cell structure and function   32(1) 9-15   2007   [Refereed]
Negishi H, Fujita Y, Yanai H, Sakaguchi S, Ouyang X, Shinohara M, Takayanagi H, Ohba Y, Taniguchi T, Honda K
Proceedings of the National Academy of Sciences of the United States of America   103(41) 15136-15141   Oct 2006   [Refereed]
Shibue T, Suzuki S, Okamoto H, Yoshida H, Ohba Y, Takaoka A, Taniguchi T
The EMBO journal   25(20) 4952-4962   Oct 2006   [Refereed]
Negishi H, Ohba Y, Yanai H, Takaoka A, Honma K, Yui K, Matsuyama T, Taniguchi T, Honda K
Proceedings of the National Academy of Sciences of the United States of America   102(44) 15989-15994   Nov 2005   [Refereed]
Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T
Nature   434(7034) 772-777   Apr 2005   [Refereed]
Honda K, Ohba Y, Yanai H, Negishi H, Mizutani T, Takaoka A, Taya C, Taniguchi T
Nature   434(7036) 1035-1040   Apr 2005   [Refereed]
Takaoka A, Yanai H, Kondo S, Duncan G, Negishi H, Mizutani T, Kano S, Honda K, Ohba Y, Mak TW, Taniguchi T
Nature   434(7030) 243-249   Mar 2005   [Refereed]
Yoshizaki H, Ohba Y, Parrini MC, Dulyaninova NG, Bresnick AR, Mochizuki N, Matsuda M
The Journal of biological chemistry   279(43) 44756-44762   Oct 2004   [Refereed]
Honda K, Yanai H, Mizutani T, Negishi H, Shimada N, Suzuki N, Ohba Y, Takaoka A, Yeh WC, Taniguchi T
Proceedings of the National Academy of Sciences of the United States of America   101(43) 15416-15421   Oct 2004   [Refereed]
Miyagi C, Yamashita S, Ohba Y, Yoshizaki H, Matsuda M, Hirano T
The Journal of cell biology   166(7) 975-981   Sep 2004   [Refereed]
Takaya A, Ohba Y, Kurokawa K, Matsuda M
Molecular biology of the cell   15 2549-2557   Jun 2004   [Refereed]
[Visualization of signal transduction of Ras].
Ohba Y, Matsuda M
Seikagaku. The Journal of Japanese Biochemical Society   76 16-28   Jan 2004   [Refereed]
Yoshizaki H, Ohba Y, Kurokawa K, Itoh RE, Nakamura T, Mochizuki N, Nagashima K, Matsuda M
The Journal of cell biology   162(2) 223-232   Jul 2003   [Refereed]
Ohba Y, Kurokawa K, Matsuda M
The EMBO journal   22(4) 859-869   Feb 2003   [Refereed]
Sakakibara A, Ohba Y, Kurokawa K, Matsuda M, Hattori S
Journal of cell science   115(24) 4915-4924   Dec 2002   [Refereed]
Itoh RE, Kurokawa K, Ohba Y, Yoshizaki H, Mochizuki N, Matsuda M
Molecular and cellular biology   22(18) 6582-6591   Sep 2002   [Refereed]

Association Memberships

 
 

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2008 - 2010    Investigator(s): Yusuke OHBA
We have hereby identified transcription factor 8 (TCF8) as a regulator of epithelial-mesenchymal transition, a critical process in cancer invasion/metastasis and endothelial mobilization to tumor angiogenesis. The molecular mechanisms by which TCF...
Spatiotemporal regulation of signal transduction pathways using fluorescence imaging
Grant-in-Aid for Scientific Research
Project Year: 2006   
Spatiotemporal dynamics of tumor cell-microenvironment interaction
Grant-in-Aid for Scientific Research
Project Year: 2008   
Clinical application of fluorescence imaging
Cooperative Research
Project Year: 2010   

Patents

 
2009-278942
WO 2010/005046
WO/2011/046160
WO/2011/126071