2021年8月16日
D-Serine mediates cellular proliferation for kidney remodeling
Kidney360
- 巻
- 2
- 号
- 10
- 開始ページ
- 10.34067/KID.0000832021
- 終了ページ
- 10.34067/KID.0000832021
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.34067/kid.0000832021
- 出版者・発行元
- American Society of Nephrology (ASN)
Background: D-Serine, a long-term undetected enantiomer of serine, is a biomarker that reflects kidney function and disease activity. The physiological functions of D-serine have been unclear. Methods: Dynamics of D-serine was assessed by measuring D-serine in human samples of living kidney donors using two-dimensional high-performance liquid chromatography, and by auto-radiographic studies in mice. Effects of D-serine on kidney were examined by gene expression profiling and metabolic studies using unilateral nephrectomy mice, and genetically modified cells. Results: Unilateral nephrectomy in human living kidney donors decreases urinary excretion and thus increases the blood level of D-serine. D-Serine is quickly and dominantly distributed to the kidney upon injection in mice, suggesting that the kidney is a main target organ. Treatment of D-serine at low dose promotes the enlargement of remnant kidney in mouse model. Mechanistically, D-serine activates the cell cycle for tissue remodeling through an mTOR-related pathway. Conclusions: D-Serine is a physiological molecule that promotes kidney remodeling. Besides its function as a biomarker, D-serine has a physiological activity that influences kidney function.
- リンク情報
- ID情報
-
- DOI : 10.34067/kid.0000832021
- ISSN : 2641-7650
- eISSN : 2641-7650
- ORCIDのPut Code : 98544890
- PubMed ID : 35372967
- PubMed Central 記事ID : PMC8785787