2010年7月
Heteroatom-Directed Alkylcyanation of Alkynes
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- ,
- ,
- 巻
- 132
- 号
- 29
- 開始ページ
- 10024
- 終了ページ
- 10026
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/ja1017078
- 出版者・発行元
- AMER CHEMICAL SOC
Alkanenitriles having a heteroatom such as nitrogen, oxygen, and sulfur at the gamma-position are found to add across alkynes stereo- and regioselectively by nickel/Lewis acid catalysis to give highly substituted acrylonitriles. The heteroatom functionalities likely coordinate to the nickel center to make oxidative addition of the C-CN bonds of the alkyl cyanides kinetically favorable, forming a five-membered nickelacycle intermediate and, thus, preventing beta-hydride elimination to allow the alkylcyanation reaction.
- リンク情報
- ID情報
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- DOI : 10.1021/ja1017078
- ISSN : 0002-7863
- eISSN : 1520-5126
- Web of Science ID : WOS:000280227700035