論文

国際誌
2020年2月24日

MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells.

Developmental cell
  • Kei-Ichiro Ishiguro
  • ,
  • Kumi Matsuura
  • ,
  • Naoki Tani
  • ,
  • Naoki Takeda
  • ,
  • Shingo Usuki
  • ,
  • Mariko Yamane
  • ,
  • Michihiko Sugimoto
  • ,
  • Sayoko Fujimura
  • ,
  • Mihoko Hosokawa
  • ,
  • Shinichiro Chuma
  • ,
  • Minoru S H Ko
  • ,
  • Kimi Araki
  • ,
  • Hitoshi Niwa

52
4
開始ページ
429
終了ページ
445
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.devcel.2020.01.010

The mechanisms regulating meiotic initiation in mammals are enigmatic. It is known that retinoic acid (RA) signaling plays a pivotal role during meiotic initiation. STRA8, which is expressed in response to RA, is thought to be a key factor promoting meiotic initiation. However, the specific role of STRA8 in meiotic initiation has remained elusive. Here, we identified MEIOSIN as a germ-cell-specific factor that associates with STRA8. MEIOSIN, like STRA8, is expressed in response to RA and plays an essential role in meiotic initiation in both males and females. Functional analyses revealed that MEIOSIN acts as a transcription factor together with STRA8, and that both factors are critical for driving meiotic gene activation. Furthermore, temporally restricted expression of MEIOSIN leads to meiotic entry decision during spermatogenesis. The present study demonstrates that MEIOSIN, in collaboration with STRA8, plays a central role in regulating the mitosis to meiosis germ cell fate decision in mammals.

リンク情報
DOI
https://doi.org/10.1016/j.devcel.2020.01.010
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32032549

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