OKAMURA Emiko

J-GLOBAL         Last updated: Jun 12, 2018 at 19:42
 
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Name
OKAMURA Emiko
E-mail
emikogm.himeji-du.ac.jp
URL
http://www.himeji-du.ac.jp/faculty/dp_pharm/pharm/ph/e-bpc-top.html
Affiliation
Himeji Dokkyo University
Section
Faculty of Pharmaceutical Sciences
Job title
Professor
Degree
Doctor of Pharmaceutical Science(Kyoto University), Master of Pharmaceutical Science(Kyoto University)

Research Areas

 
 

Academic & Professional Experience

 
Apr 2007
 - 
Today
Professor, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University
 
Oct 2006
 - 
Mar 2007
Associate Professor, Institute for Chemical Research, Kyoto University
 
Jul 2001
 - 
Sep 2006
Assistant Professor, Institute for Chemical Research, Kyoto University
 
Feb 1983
 - 
Jun 2001
Research Associate, Institute for Chemical Research, Kyoto University
 

Education

 
Apr 1982
 - 
Jan 1983
Doctor Course, Graduate School of Pharmaceutical Sciences, Kyoto University
 
Apr 1980
 - 
Mar 1982
Master Course, Gracuate School of Pharmaceutical Sciences, Kyoto University
 
Apr 1976
 - 
Mar 1980
Faculty of Pharmaceutical Sciences, Kyoto University
 

Committee Memberships

 
May 2013
 - 
Today
The Membrane Society of Japan  Councilor
 
Apr 2013
 - 
Today
Japan Oil Chemists' Society  Kansai Branch, Manager
 
Mar 2012
 - 
Today
The Chemical Society of Japan  The Division of Colloid and Surface Chemistry, Kansai Branch, Director
 
2009
 - 
Today
The Membrane Society of Japan  Editor, Editorial Committee of "Membrane",
 
2007
 - 
Today
The Pharmaceutical Society of Japan  Member of Committee, Kinki Branch
 
2002
 - 
Today
The Chemical Society of Japan, The Division of Colloid and Surface Chemistry  Member of Committee, Kansai Branch
 
2001
 - 
Today
Research Group of Anesthetic Mechanism in Japan  Councilor
 

Awards & Honors

 
2012
Oleoscience Editor's Award, The Japan Oil Chemists Society
 
2009
The Shiseido Female Researcher Science Grant
 

Published Papers

 
Glycosaminoglycan Binding and Non-Endocytic Membrane Translocation of Cell-Permeable Octaarginine Monitored by Real-Time In-Cell NMR Spectroscopy
Y. Takechi-Haraya, K. Aki, Y. Tohyama, Y. Harano, T. Kawakami, H. Saito, E. Okamura
Pharmaceuticals   10 42   2017   [Refereed]
K. Aki and E. Okamura
Scientific Reports   6 21594   2016   [Refereed]
Kinetics of Membrane Binding and Mobility of Drugs by Multinuclear Dynamic NMR in Situ
OKAMURA Emiko
Journal of the Society of Japanese Women Scientists   16 7-14   2016   [Invited]
Y. Takechi, Y. Shintani, D. Kimoto, and E. Okamura
Membrane   40 38-45   2015   [Refereed]
N. Yoshii, T. Emoto, and E. Okamura,
Colloid Surf. B-Biointerfaces   106 22-27   2013   [Refereed]
Y. Takechi, H. Saito, and E. Okamura
Chem. Phys. Lett.   570 136-140   2013   [Refereed]
Yuki Takechi, Chiharu Mizuguchi, Masafumi Tanaka, Toru Kawakami, Saburo Aimoto, Emiko Okamura, Hiroyuki Saito
Chem. Lett.   41(10) 1374-1376   2012   [Refereed]
YOSHII Noriyuki, EMOTO Tomomi, OKAMURA Emiko
BIOPHYSICS   7 105-111   2011   [Refereed]
YOSHII Noriyuki, OKAMURA Emiko
J. Phys. Chem. B   115 11074-11080   2011   [Refereed]
N.Yoshii and E.Okamura
Chem. Phys. Lett.   474(4-6) 357-361   2009   [Refereed]
E.Okamura and N.Yoshii
J. Chem. Phys.   129(21) 215102   2008   [Refereed]
C.Giordani, C.Wakai, K.Yoshida, E.Okamura, N.Matubayasi, and M.Nakahara
J. Phys. Chem. B   112(9) 2622-2628   2008   [Refereed]
C.Giordani, C.Wakai, E.Okamura, N.Matubayasi, and M.Nakahara
J. Phys. Chem. B   110(31) 15205-15211   2006   [Refereed]
E.Okamura and M.Nakahara
International Congress Series   1283 203-206   2005   [Refereed]
E.Okamura, K.Ninomiya, S.Futaki, Y.Nagai, T.Kimura, C.Wakai, N.Matubayasi, Y.Sugiura, and M.Nakahara
Chem. Lett.   34 1064-1065   2005   [Refereed]
Static and Dynamic NMR Studies of Anesthetics in Membranes
E.Okamura and M.Nakahara
Anesthesia and Resuscitation   41 21-22   2005
E.Okamura, C.Wakai, N.Matubayasi, Y.Sugiura, and M.Nakahara
Physical Review Letters   93 248101   2004   [Refereed]
T. Kimura, E.Okamura, N.Matubayasi, K. Asami, and M.Nakahara
Biophysical Journal   87 375-385   2004   [Refereed]
Location and Side-Chain Conformation of a Neuropeptide, Achatin-I in Phospholipid Bilayer Membrane: A High-Resolution NMR Study
T. Kimura, E.Okamura, N.Matubayasi, and M.Nakahara
Biophysical Journal   86 559A   2004
E.Okamura, T.Kimura, M.Nakahara, M.Tanaka, T.Handa, and H.Saito
J. Phys. Chem. B   105(50) 12616-12621   2001   [Refereed]
H.Saito, M.Tanaka, E.Okamura, T.Kimura, M.Nakahara, and T.Handa
Langmuir   17(8) 2528-2532   2001   [Refereed]
NMR Specification of Lipid Bilayer Interfaces as Drug Delivery Sites
E.Okamura, R.Kakitsubo, and M.Nakahara
Stud. Surf. Sci. Catal.   132 1045-1048   2001   [Refereed]
NMR Determination of the Delivery Site of Local Anesthetics in Phospholipid Bilayer Membranes
E.Okamura, R.Kakitsubo, and M.Nakahara
Progress in Anesthetic Mechanism   6 542-547   2000   [Refereed]
E.Okamura and M.Nakahara
J. Phys. Chem. B   103(17) 3505-3509   1999   [Refereed]
E.Okamura, R.Kakitsubo, and M.Nakahara
Langmuir   15(23) 8332-8335   1999   [Refereed]
E.Okamura, N.Fukushima, and S.Hayashi
Langmuir   15(10) 3589-3594   1999   [Refereed]
E.Okamura, C.Wakai, N.Matubayasi, and M.Nakahara
Chem. Lett.   (10) 1061-1062   1997   [Refereed]
Quantitative Analysis of Molecular Orientation in Chlorophyll a Langmuir Monolayer : A Polarized Visible Reflection Spectroscopic Study
E.Okamura, T.Hasegawa, and J.Umemura
Biophys. J.   69 1142-1147   1995   [Refereed]
K.Fujita, S.Kimura, Y.Imanishi, E.Okamura, and J.Umemura
Langmuir   11 1675-1679   1995   [Refereed]
Orientation and Association of Helical Peptides in Phospholipid Bilayer Membrane
S.Kimura, J.Chou, Y.Imanishi, E.Okamura, and J.Umemura
Peptide Chemistry   1994 133-136   1995   [Refereed]
Y.Matsumura, E.Okamura, H.Hidaka, M.Miyabe, and T.Mori
Biosci. Biotech. Biochem.   59 1688-1693   1995   [Refereed]
Effect of Wax Addition on Gel - to - Liquid-Crystalline Phase Transition of Palm-Oil as Studied by FT-IR Spectroscopy
E.Okamura, Y.Matsumura, and T.Takenaka
Bull. Inst. Chem. Res., Kyoto Univ.   71 188-192   1993   [Refereed]
Fourier Transform Infrared / Attenuated Total Reflection Study on Subtransition of Hydrated Dipalmitoylphosphatidylcholine Multibilayers
E.Okamura, J.Umemura, and T.Takenaka
Vibrational Spectrosc.   2 95-100   1991   [Refereed]
A Comparative Study on Interactions of alpha-Aminoisobutyric Acid Containing Antibiotic Peptides, Trichopolyn I and Hypelcin A with Phosphatidylcholine Bilayers
K.Matsuzaki, T.Shioyama, E.Okamura, J.Umemura, T.Takenaka, Y.Takaishi, T.Fujita, and K.Miyajima
Biochim. Biophys. Acta   1070 419-428   1991   [Refereed]
Orientation Studies of Hydrated Dipalmitoylphosphatidylcholine Multibilayers by Polarized FTIR-ATR Spectroscopy
E.Okamura, J.Umemura, and T.Takenaka
Biochim. Biophys. Acta   1025 94-98   1990   [Refereed]
Fourier Transform Infrared - Attenuated Total Reflection Spectroscopy of Hydration of Dimyristoylphosphatidylcholine Multibilayers
Lisbeth Ter-Minassian-Saraga, E.Okamura, J.Umemura, and T. Takenaka
Biochim. Biophys. Acta   946 417-423   1988   [Refereed]
Orientation of Gramicidin D Incorporated into Phospholipid Multibilayers: A Fourier Transform Infrared - Attenuated Total Reflection Spectroscopic Study
E.Okamura, J.Umemura, and T.Takenaka
Biochim. Biophys. Acta   856 68-75   1986   [Refereed]
M.Nakagaki and E.Okamura
Bull. Chem. Soc. Jpn.   58 546-549   1985   [Refereed]
Fourier Transform Infrared - Attenuated Total Reflection Spectra of Dipalmitoylphosphatidylcholine Monomolecular Films
E.Okamura, J.Umemura, and T.Takenaka
Biochim. Biophys. Acta   812 139-146   1985   [Refereed]
M.Nakagaki and E.Okamura
Bull. Chem. Soc. Jpn.   56 1607-1611   1983   [Refereed]
M.Nakagaki, E.Okamura, and S.Kubota
Bull. Chem. Soc. Jpn.   56 3730-3734   1983   [Refereed]
M.Nakagaki and E.Okamura
Bull. Chem. Soc. Jpn.   55 1352-1356   1982   [Refereed]
M.Nakagaki and E.Okamura
Bull. Chem. Soc. Jpn.   55 3381-3385   1982   [Refereed]

Misc

 
Mobility of Drugs in Lipid Membranes by NMR
YOSHII Noriyuki, OKAMURA Emiko
Oleoscience   11(6) 213-220   2011   [Invited]
YOSHII Noriyuki, OKAMURA Emiko
Membrane   36(1) 9-15   2011   [Refereed][Invited]
E. Okamura
Membrane   34(3) 117-125   2009   [Invited]
Drug Binding and Dynamics in Membranes by High-Resolution Solution NMR
E. Okamura
Ensemble   11(4) 18-21   2009   [Invited]
Molecular Dynamics in Lipid Bilayer Membranes by NMR
E.Okamura and M.Nakahara
Chemistry   59 66-67   2004   [Invited]
NMR Studies on Lipid Bilayer Interfaces Coupled with Anesthetics and Endocrine Disruptors
E.Okamura and M.Nakahara
in Liquid Interfaces in Chemical, Biological, and Pharmaceutical Applications, Ed. by A.G. Volkov, Marcel Dekker, New York   775-805   2001   [Invited]

Books etc

 
NMR OF DRUG DELIVERY COUPLED WITH LIPID MEMBRANE DYNAMICS
OKAMURA Emiko (Part:Contributor, Chapter 30)
Encyclopedia of Biocolloid and Biointerface Science, Volume 1, John Wiley & Sons, Inc   2016   
Fluctuation, Dynamics, and Function―Dojin Bioscience Series 10
OKAMURA Emiko (Part:Contributor, Chapter 14 Biomembranes)
Kagakudojin   Sep 2013   
NMR Studies on Lipid Bilayer Interfaces Coupled with Anesthetics and Endocrine Disruptors (Chapter 32)
Liquid Interfaces in Chemical, Biological, and Pharmaceutical Applications, Marcel Dekker   2001   

Teaching Experience

 
 

Research Grants & Projects

 
Quantitative Analysis of Drug Deliveries to Living Cells by Real-Time In-Cell NMR Spectroscopy
JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2015 - Mar 2019    Investigator(s): OKAMURA Emiko
Multinuclear Dynamic NMR of Diffusion and Transport of Polypeptides by Membrane Thermal Fluctuation
JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2012 - Mar 2015    Investigator(s): OKAMURA Emiko
The Quantitative In-Cell NMR Observation of Drug Transport into Living Cells to Establish its Prediction Model
Hyogo Science and Technology Association: 2013 Research Grant
Project Year: Apr 2013 - Mar 2014    Investigator(s): OKAMURA Emiko
Multinuclear dynamic NMR of drug transport relating to the fluctuation of biomembranes
MEXT, Japan: Grant-in Aid for Scientific Research on Innovative Areas
Project Year: Apr 2009 - Mar 2011    Investigator(s): OKAMURA Emiko
Multinuclear, Dynamic NMR of Membrane Thermal Fluctuation and Drug Deliveries
JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2008 - Mar 2011    Investigator(s): Emiko OKAMURA
A large number of drugs, especially small molecules, are transferred to the inside of the cell by passing through the cell membrane based on the passive transport mechanism. The drug transport is dynamic; it is dominated by the molecular motion an...
In-cell NMR spectroscopy of drugs: noninvasive detection and transport mechanism
The Shiseido Female Researcher Science Grant
Project Year: Jun 2009 - May 2010    Investigator(s): Emiko OKAMURA
Molecular Dynamics in Lipid Rafts by High-Sensitivity, High-Resolution NMR
JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2005 - Mar 2007    Investigator(s): Emiko OKAMURA
Membrane Transport of Endocrine Disruptors by Static and Dynamic NMR
JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2002 - Mar 2004    Investigator(s): Emiko OKAMURA
High-Sensitivity, High-Resolution NMR Study of Drug Delivery into Model and Cell Membranes
The Other Research Programs

Social Contribution

 
How drugs enter the cell? Investigation of drug movements in a body
[Lecturer]  Himeji Dokkyo University & Himeji City  Senior Open College at Himeji  15 Nov 2013 - 15 Nov 2013