2011年
A case of marked efficacy of low-dose UFT against metastatic bladder cancer
Japanese Journal of Cancer and Chemotherapy
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- 巻
- 38
- 号
- 6
- 開始ページ
- 1029
- 終了ページ
- 1033
- 記述言語
- 日本語
- 掲載種別
- 出版者・発行元
- Japanese Journal of Cancer and Chemotherapy Publishers Inc.
The two regimens of treatment consisted of either cisplatin and gemcitabine or methotrexate, vinblastine, doxorubicin and cisplatin (M-VAC), which has been widely adopted for muscle-invasive bladder cancer. But because of its potential toxicity, its tolerability has been troublesome, especially for very elderly patients. Herein, we report a bladder cancer case with multiple metastases which were controlled by low-dose UFT. At the same time, the chemosensitivity of 5-FU combined with uracyl or 5-chloro-2, 4-dihydroxypyridine (CDHP). Four invasive bladder cancer cell lines were evaluated with a collagen gel droplet embedded drug sensitivity test (CD-DST). Three of four cell lines showed an increasing sensitivity to 5-FU with the combination of uracil or CDHP. Examinations with CD-DST may provide important scientific evidence for determining suitable chemotherapy for patients with advanced bladder cancer.
- リンク情報
- ID情報
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- ISSN : 0385-0684
- PubMed ID : 21677502
- SCOPUS ID : 84866995510