論文

査読有り
1994年10月

MINISATELLITE MUTATION-RATE VARIATION ASSOCIATED WITH A FLANKING DNA-SEQUENCE POLYMORPHISM

NATURE GENETICS
  • DG MONCKTON
  • ,
  • R NEUMANN
  • ,
  • T GURAM
  • ,
  • N FRETWELL
  • ,
  • K TAMAKI
  • ,
  • A MACLEOD
  • ,
  • AJ JEFFREYS

8
2
開始ページ
162
終了ページ
170
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/ng1094-162
出版者・発行元
NATURE PUBLISHING CO

Human minisatellite mutation in the male germline frequently involves complex interallelic gene conversion events restricted to one end of the tandem repeat array. Some alleles at minisatellite MS32 show reduced variability in human populations and are associated with a G to C transversion upstream of the array. Analysis of single sperm demonstrated a frequently profound reduction in mutation rate at alleles carrying the C variant. This mutation suppression acts in cis, but does not affect the ability of an allele to act as sequence donor during gene conversion. This mutation rate polymorphism provides strong evidence for elements near the minisatellite that regulate tandem repeat instability.

リンク情報
DOI
https://doi.org/10.1038/ng1094-162
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1994PL12300018&DestApp=WOS_CPL
ID情報
  • DOI : 10.1038/ng1094-162
  • ISSN : 1061-4036
  • Web of Science ID : WOS:A1994PL12300018

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