Makoto Adachi

Profile Information

Affiliation: Assistant Professor,Assistant Professor, Graduate School of Medicine, Graduate School of Medicine Medicine, Kyoto University

J-GLOBAL ID: 200901066148464145
researchmap Member ID: 5000031312

Research Interests

Research Areas

Life sciences / Cell biology /

Research History

Apr, 2007

Graduate School of Medicine, Kyoto University
Apr, 2007

Assistant Professor, Graduate School of Medicine, Kyoto University
Jul, 2001

Graduate School of Medicine, Kyoto University
Jul, 2001

Research Associate, Graduate School of Medicine, Kyoto University
Apr, 2001

日本学術振興会特別研究員(PD)
Apr, 2001

Research Fellow (PD), Japan Society for the Promotion of Science
現在に至る

Papers

Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis

Makoto Adachi, Asami Kawasaki, Hisashi Nojima, Eisuke Nishida, Sachiko Tsukita

GENES TO CELLS, 19(11) 803-820, Nov, 2014 Peer-reviewed
Polarity-Dependent Distribution of Angiomotin Localizes Hippo Signaling in Preimplantation Embryos

Yoshikazu Hirate, Shino Hirahara, Ken-ichi Inoue, Atsushi Suzuki, Vernadeth B. Alarcon, Kazunori Akimoto, Takaaki Hirai, Takeshi Hara, Makoto Adachi, Kazuhiro Chida …

CURRENT BIOLOGY, 23(13) 1181-1194, Jul, 2013 Peer-reviewed
Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling

Tomoki Yano, Yuji Yamazaki, Makoto Adachi, Katsuya Okawa, Philippe Fort, Masami Uji, Shoichiro Tsukita, Sachiko Tsukita

JOURNAL OF CELL BIOLOGY, 193(2) 319-332, Apr, 2011 Peer-reviewed
Similar and Distinct Properties of MUPP1 and Patj, Two Homologous PDZ Domain-Containing Tight-Junction Proteins

Makoto Adachi, Yoko Hamazaki, Yuka Kobayashi, Masahiko Itoh, Sachiko Tsukita, Mikio Furuse, Shoichiro Tsukita

MOLECULAR AND CELLULAR BIOLOGY, 29(9) 2372-2389, May, 2009 Peer-reviewed
IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade

Hisashi Nojima, Makoto Adachi, Takeshi Matsui, Katsuya Okawa, Shoichiro Tsukita, Sachiko Tsukita

NATURE CELL BIOLOGY, 10(8) 971-978, Aug, 2008 Peer-reviewed
Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning

Miho Matsuda, Yuka Kobayashi, Sayuri Masuda, Makoto Adachi, Tsuyoshi Watanabe, Jun K. Yamashita, Eiichiro Nishi, Shoichiro Tsukita, Mikio Furuse

EXPERIMENTAL CELL RESEARCH, 314(5) 939-949, Mar, 2008 Peer-reviewed
Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties

Yuko Sugihara-Mizuno, Makoto Adachi, Yuka Kobayashi, Yoko Hamazaki, Miyuki Nishimura, Toshio Imai, Mikio Furuse, Shoichiro Tsukita

GENES TO CELLS, 12(4) 473-486, Apr, 2007 Peer-reviewed
Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein

Makoto Adachi, Akihito Inoko, Masaki Hata, Kyoko Furuse, Kazuaki Umeda, Masahiko Itoh, Shoichiro Tsukita

MOLECULAR AND CELLULAR BIOLOGY, 26(23) 9003-9015, Dec, 2006 Peer-reviewed
The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response. EMBO J. 23:2226-2234.

Mizuno, T, Hisamoto, N, Terada, T, Kondo, T, Adachi, M, Nishida, E, Kim, D.H, Ausubel, F.M, Matsumoto, K

2004 Peer-reviewed
Subcellular localization of MAPKs.

M. Adachi, E. Nishida

Methods in molecular biology (Clifton, N.J.), 250 145-154, 2004 Peer-reviewed
Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

T Tanoue, R Maeda, M Adachi, E Nishida

EMBO JOURNAL, 20(3) 466-479, Feb, 2001 Peer-reviewed
Identification and characterization of a novel MAP kinase kinase kinase, MLTK. J. Biol. Chem. 276:4276-4286. (*equal contribution)

Gotoh, I, Adachi, M, Nishida, E

2001 Peer-reviewed
Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism

M Adachi, M Fukuda, E Nishida

JOURNAL OF CELL BIOLOGY, 148(5) 849-856, Mar, 2000 Peer-reviewed
A conserved docking motif in MAP kinases common to substrates, activators and regulators. Nat. Cell Biol. 2:110-116. (*equal contribution)

Tanoue, T, Adachi, M, Moriguchi, T, Nishida, E

2000 Peer-reviewed
Control of the cell morphology and the S phase entry by mitogen-activated protein kinase kinase - A regulatory role of its N-terminal region

Gotoh, I, M Fukuda, M Adachi, E Nishida

JOURNAL OF BIOLOGICAL CHEMISTRY, 274(17) 11874-11880, Apr, 1999 Peer-reviewed
Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer. EMBO J. 18:5347-5358.

Adachi, M, Fukuda, M, Nishida, E

1999 Peer-reviewed
A novel regulatory mechanism in the mitogen-activated protein (MAP) kinase cascade - Role of nuclear export signal of MAP kinase kinase

M Fukuda, Gotoh, I, M Adachi, Y Gotoh, E Nishida

JOURNAL OF BIOLOGICAL CHEMISTRY, 272(51) 32642-32648, Dec, 1997 Peer-reviewed
CRM1 is responsible for intracellular transport mediated by the nuclear export signal

M Fukuda, S Asano, T Nakamura, M Adachi, M Yoshida, M Yanagida, E Nishida

NATURE, 390(6657) 308-311, Nov, 1997 Peer-reviewed

Misc.

哺乳類細胞における細胞質分裂へのIQGAPファミリー分子の関与

ADACHI MAKOTO, KAWASAKI ASAMI, NOJIMA HISASHI, NISHIDA EISUKE, TSUKITA SACHIKO

日本分子生物学会年会プログラム・要旨集(Web), 36th 3P-0434 (WEB ONLY), 2013
Rac1を介したE‐cadherin転写制御因子としてのadherens junction構成タンパク質Tara/TRIOBP1の機能解析

YANO TOMOKI, YAMAZAKI YUJI, ADACHI MAKOTO, OKAWA KATSUYA, FORT PHILIPPE, TSUKITA SHOICHIRO, TSUKITA SACHIKO

生化学, ROMBUNNO.2T10P-16, 2011
細胞質分裂におけるIQGAP3の関与

KAWASAKI ASAMI, ADACHI MAKOTO, NOJIMA HISASHI, KUNIMOTO KOUSHI, YAMASAKI YUJI, TAMURA ATSUSHI, TSUKITA SACHIKO

生化学, ROMBUNNO.4P-0658, 2010
Rac-GEF-binding Tara builds E-cadherin/Ankyrin/Spectrin frameworks in the junctional circunferential ring.

YANO TOMOKI, YAMAZAKI YUJI, ADACHI MAKOTO, OKAWA KATSUYA, TSUKITA SHOICHIRO, TSUKITA SACHIKO

生化学, ROMBUNNO.2P-695, Sep 25, 2009
タイトジャンクションに局在する2つの類似したPDZドメイン含有分子MUPP1とPatjの解析

ADACHI MAKOTO, HAMAZAKI YOKO, KOBAYASHI YUKA, TSUKITA SACHIKO, FURUSE MIKIO, TSUKITA SHOICHIRO

生化学, 2P-0396, 2007
MKP‐1を介したMAPキナーゼ経路とNotch経路のクロストークの解析

KONDO KUNIO, ADACHI MAKOTO, SUNADOME KAZUNORI, NISHIDA EISUKE

日本分子生物学会年会講演要旨集, 28th 621, Nov 25, 2005
線虫MAPキナーゼホスファターゼVHP‐1はストレス応答において新規JNK様シグナル伝達経路を制御する

MIZUNO TOMOAKI, HISAMOTO NAOKI, TERADA TAKASHI, KONDO TAE, ADACHI MAKOTO, NISHIDA EISUKE, MATSUMOTO KUNIHIRO

日本分子生物学会年会プログラム・講演要旨集, 27th 584, Nov 25, 2004
NotchによるMKP‐1の誘導とC2C12細胞の筋分化

KONDO KUNIO, ADACHI MAKOTO, NISHIDA EISUKE

日本細胞生物学会大会講演要旨集, 56th 55, 2003
新規MAPKKKの同定,活性化機構および機能の解析

GOTO ISAMU, ADACHI MAKOTO, NISHIDA EISUKE

日本分子生物学会年会プログラム・講演要旨集, 23rd 553, Nov 25, 2000
情報伝達研究の最前線情報伝達の基本経路 MAPキナーゼファミリー

ADACHI MAKOTO, NISHIDA EISUKE

医学のあゆみ, 194(5) 277-281, Jul 29, 2000
MAPキナーゼの核移行および核外移行の制御機構

ADACHI MAKOTO, FUKUDA MAKOTO, NISHIDA EISUKE

日本分子生物学会年会プログラム・講演要旨集, 22nd 427, Nov 22, 1999
MAPキナーゼファミリーの分子認識機構の解析

TANOUE TAKUJI, ADACHI MAKOTO, MORIGUCHI TETSUO, NISHIDA EISUKE

日本分子生物学会年会プログラム・講演要旨集, 22nd 427, Nov 22, 1999
Regulation of the nucleocytoplasmic transport of MAP kinases.

ADACHI MAKOTO, FUKUDA MAKOTO, NISHIDA EISUKE

実験医学, 17(2) 100-104, Feb, 1999
Regulation of Nucleocytoplasmic Transport of MAP kinase.

ADACHI MAKOTO, FUKUDA MAKOTO, NISHIDA EISUKE

日本分子生物学会年会プログラム・講演要旨集, 20th 460, Dec, 1997
Molecular mechanisms of nucleocytoplasmic transport of MAP kinase kinase and MAP kinase.

NISHIDA EISUKE, FUKUDA MAKOTO, GOTO ISAMU, ASANO SHIRO, ADACHI MAKOTO, WATANABE MINA

日本分子生物学会年会プログラム・講演要旨集, 20th 221, Dec, 1997
MAPキナーゼキナーゼの核外移行シグナル(NES)の役割および核外移行の分子機構の解析

FUKUDA MAKOTO, GOTO ISAMU, ASANO SHIRO, ADACHI MAKOTO, NISHIDA EISUKE

日本細胞生物学会大会講演要旨集, 50th 31, 1997

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