中津可道 (Yoshimichi Nakatsu) - マイポータル

基本情報

所属: 九州大学大学院医学研究院基礎医学部門生体制御学講座基礎放射線医学分野准教授

学位: 博士（理学）(九州大学)

J-GLOBAL ID: 200901003175210340
researchmap会員ID: 5000031352

外部リンク: http://www.med.kyushu-u.ac.jp/biophys/

研究キーワード

研究分野

経歴

2007年 - 現在

九州大学大学院医学研究院, 准教授
2001年 - 2007年

九州大学大学院医学研究院, 助教授
2000年 - 2001年

大阪大学細胞生体工学センター, 助教授
2000年 - 2001年

Associate Professor, Institute for Molecular and Cellular Biology, Osaka University.
1994年 - 2000年

大阪大学細胞生体工学センター, 助手
1994年 - 2000年

Research Associate, Institute for Molecular and Cellular Biology, Osaka University.
1990年 - 1994年

米国フォックスチェイスがんセンター, ポストドクトラルフェロー
1990年 - 1994年

Postdoctoral fellow, Fox Chase Cancer Center.
1988年 - 1990年

九州大学医学部, 助手
1988年 - 1990年

Research Associate, Kyushu University.
1985年 - 1988年

日本学術振興会特別研究員（がん）
1985年 - 1988年

Postdoctoral fellow, Japan Society for the Promotion of Science.

学歴

論文

Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro.

Yusuke Matsuno, Yuko Atsumi, Atsuhiro Shimizu, Kotoe Katayama, Haruka Fujimori, Mai Hyodo, Yusuke Minakawa, Yoshimichi Nakatsu, Syuzo Kaneko, Ryuji Hamamoto …

Nature communications 10(1) 3925-3925 2019年9月2日
Differential genomic destabilisation in human cells with pathogenic MSH2 mutations introduced by genome editing

Genki Hayashida, Seijiro Shioi, Kyoko Hidaka, Ryosuke Fujikane, Masumi Hidaka, Toshiki Tsurimoto, Teruhisa Tsuzuki, Shinya Oda, Yoshimichi Nakatsu

Experimental Cell Research 377(1-2) 24-35 2019年4月15日
Budding Uninhibited by Benzimidazole-1 Insufficiency Prevents Acute Renal Failure in Severe Sepsis by Maintaining Anticoagulant Functions of Vascular Endothelial Cells

Yutaka Matsubara, Takuya Matsumoto, Keiji Yoshiya, Ayae Yoshida, Seiichi Ikeda, Tadashi Furuyama, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Masatoshi Nomura, Yoshihiko Maehara

Shock 51(3) 364-371 2019年3月1日
Effects of mismatches distant from the target position on gene correction with a 5′-tailed duplex

Tetsuya Suzuki, Yuri Yanai, Natsuki Nishigaki, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Hiroyuki Kamiya

Journal of Bioscience and Bioengineering 125(5) 619-623 2018年5月1日
Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway

Issei Egashira, Fumi Takahashi-Yanaga, Risa Nishida, Masaki Arioka, Kazunobu Igawa, Katsuhiko Tomooka, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Yusaku Nakabeppu, Takanari Kitazono …

Cancer Science 108(1) 108-115 2017年1月
GENE TRANSFER BY CIRCULATING PLASMA BUBBLE FLOW

Yoko Yamanishi, Ryotaro Tanaka, Yuta Arakawa, Yoshimichi Nakatsu

30TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2017) 444-447 2017年
BUBR1 Insufficiency in Mice Increases their Sensitivity to Oxidative Stress

Daisuke Matsuda, Takuya Matsumoto, Kenichi Honma, Ayae Ikawa-Yoshida, Mitsuho Onimaru, Tadashi Furuyama, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Yoshihiko Maehara

IN VIVO 30(6) 769-776 2016年11月
BubR1 Insufficiency Impairs Liver Regeneration in Aged Mice after Hepatectomy through Intercalated Disc Abnormality

Ayae Ikawa-Yoshida, Takuya Matsumoto, Shinji Okano, Yukihiko Aoyagi, Yutaka Matsubara, Tadashi Furuyama, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Mitsuho Onimaru, Tomoko Ohkusa …

SCIENTIFIC REPORTS 6 2016年8月
BTK gene targeting by homologous recombination using a helper-dependent adenovirus/adeno-associated virus hybrid vector

H. Yamamoto, M. Ishimura, M. Ochiai, H. Takada, K. Kusuhara, Y. Nakatsu, T. Tsuzuki, K. Mitani, T. Hara

GENE THERAPY 23(2) 205-213 2016年2月
Insertion and Deletion Mismatches Distant from the Target Position Improve Gene Correction with a Tailed Duplex

Hiroyuki Kamiya, Natsuki Nishigaki, Akihiro Ikeda, Seiya Yukawa, Yukiko Morita, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Hideyoshi Harashima

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 35(7) 379-388 2016年
UV-induced mutations in epidermal cells of mice defective in DNA polymerase η and/or ι

Rie Kanao, Masayuki Yokoi, Tsuyoshi Ohkumo, Yasutaka Sakurai, Kantaro Dotsu, Shinobu Kura, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Chikahide Masutani, Fumio Hanaoka

DNA Repair 29 139-46 2015年5月
Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo

Naoya Kubokura, Fumi Takahashi-Yanaga, Masaki Arioka, Tatsuya Yoshihara, Kazunobu Igawa, Katsuhiko Tomooka, Sachio Morimoto, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Yusaku Nakabeppu …

JOURNAL OF PHARMACOLOGICAL SCIENCES 127(4) 446-455 2015年4月
BubR1 Insufficiency Inhibits Neointimal Hyperplasia Through Impaired Vascular Smooth Muscle Cell Proliferation in Mice

Ryoichi Kyuragi, Takuya Matsumoto, Yui Harada, Satoru Saito, Mitsuho Onimaru, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Masatoshi Nomura, Yoshikazu Yonemitsu, Yoshihiko Maehara

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35(2) 341-347 2015年2月
DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice

Fumi Takahashi-Yanaga, Tatsuya Yoshihara, Kentaro Jingushi, Kazuhiro Igawa, Katsuhiko Tomooka, Yutaka Watanabe, Sachio Morimoto, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Yusaku Nakabeppu …

Biochemical Pharmacology 89(3) 340-348 2014年6月
Mismatch Repair Deficient Mice Show Susceptibility to Oxidative Stress-Induced Intestinal Carcinogenesis

Jingshu Piao, Yoshimichi Nakatsu, Mizuki Ohno, Ken-ichi Taguchi, Teruhisa Tsuzuki

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 10(1) 73-79 2014年
Abnormality in Wnt Signaling is Causatively Associated with Oxidative Stress-Induced Intestinal Tumorigenesis in MUTYH-Null Mice

Takuro Isoda, Yoshimichi Nakatsu, Kazumi Yamauchi, Jingshu Piao, Takashi Yao, Hiroshi Honda, Yusaku Nakabeppu, Teruhisa Tsuzuki

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 10(8) 940-947 2014年
Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA

Teik How Lim, Ryosuke Fujikane, Shiori Sano, Ryuji Sakagami, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Mutsuo Sekiguchi, Masumi Hidaka

DNA REPAIR 11(3) 259-266 2012年3月
Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein

Riyoko Ito, Mutsuo Sekiguchi, Daiki Setoyama, Yoshimichi Nakatsu, Yuriko Yamagata, Hiroshi Hayakawa

JOURNAL OF BIOCHEMISTRY 149(6) 731-738 2011年6月
Oxidative stress-induced tumorigenesis in the small intestines of DNA repair-deficient mice.

Teruhisa Tsuzuki, Jing Shu Piao, Takuro Isoda, Kinihiko Sakumi, Yusaku Nakabeppu, Yoshimichi Nakatsu

Health physics 100(3) 293-4 2011年3月
Targeted sequence alteration of a chromosomal locus in mouse liver

Hiroyuki Kamiya, Masayuki Uchiyama, Jingshu Piao, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Hideyoshi Harashima

INTERNATIONAL JOURNAL OF PHARMACEUTICS 387(1-2) 180-183 2010年3月

もっとみる

MISC

[Oxidative DNA damage-induced intestinal tumorigenesis in Mutyh-deficient mice].

Teruhisa Tsuzuki, Jing Shu Piao, Yoshimichi Nakatsu

Nihon rinsho. Japanese journal of clinical medicine 69 Suppl 3 137-142 2011年4月1日
Oxidative damage to nucleotide: Consequences and preventive mechanisms

Yoshimichi Nakatsu, Mutsuo Sekiguchi

Oxidative Stress, Disease and Cancer 221-252 2006年1月1日
Report on the First US-Japan DNA Repair Meeting. Sendai, Japan, October 27-31, 2002.

Errol C Friedberg, Fumio Hanaoka, Kiyoji Tanaka, Samuel H Wilson, Akira Yasui

DNA repair 2(5) 639-52 2003年5月13日
Transcription-coupled repair and Cockayne syndrome

Nakatsu Y

Tanpakushitsu Kakusan Koso. 46(8 Suppl) 908-915 2001年1月1日
Loss of the xeroderma pigmentosum group A gene (XPA) enhances apoptosis of cultured cerebellar neurons induced by UV but not by low-K+ medium

Y Enokido, N Inamura, T Araki, T Satoh, H Nakane, M Yoshino, Y Nakatsu, K Tanaka, H Hatanaka

JOURNAL OF NEUROCHEMISTRY 69(1) 246-251 1997年7月
In vitro and in vivo analysis of the XPA gene

Kiyoji Tanaka, Yoshimichi Nakatsu, Masafumi Saijo, Takehiro Kobayashi, Toshiro Matsuda, Isao Kuraoka, Hiroaki Murai, Hironobu Nakane, Seiji Takeuchi, Naohiko Kodo …

Japanese Journal of Human Genetics 41 50 1996年12月1日
ORGANIZATION AND EXPRESSION OF THE HUMAN GENE FOR O6-METHYLGUANINE-DNA METHYLTRANSFERASE

Y NAKATSU, K HATTORI, H HAYAKAWA, K SHIMIZU, M SEKIGUCHI

MUTATION RESEARCH 293(2) 119-132 1993年1月
Organization and expression of the human gene for O6-methylguanine-DNA methyltransferase.

Nakatsu Y, Hattori K, Hayakawa H, Shimizu K, Sekiguchi M

Mutat Res. 263(2) 119-132 1993年
THE P-LOCUS IS CLOSELY LINKED TO THE MOUSE HOMOLOG OF A GENE FROM THE PRADER-WILLI CHROMOSOMAL REGION

Y NAKATSU, Y GONDO, MH BRILLIANT

MAMMALIAN GENOME 2(1) 69-71 1992年
Activated c-raf-1 gene from human stomach cancer

Shimizu K, Nakatsu Y, Oh-uchida M, Nomoto S, Sekiguchi M

Gan To Kagaku Ryoho. 14(6) 2140-2146 1987年6月1日
Structure of the activated c-raf-1 gene from human stomach cancer.

K. Shimizu, Y. Nakatsu, S. Nomoto, M. Sekiguchi

Princess Takamatsu symposia 17(Part 2) 85-91 1986年1月1日
S III-2. Detection of human transforming genes using DNA-transfection

K. Shimizu, Y. Nakatsu, M. Ohuchida, M. Sekiguchi

Japanese Journal of Human Genetics 30 93-94 1985年1月1日