2017年4月
Evaluation of Teicoplanin Trough Values After the Recommended Loading Dose in Children With Associated Safety Analysis
PEDIATRIC INFECTIOUS DISEASE JOURNAL
- 巻
- 36
- 号
- 4
- 開始ページ
- 398
- 終了ページ
- 400
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1097/INF.0000000000001456
- 出版者・発行元
- LIPPINCOTT WILLIAMS & WILKINS
Background: This study evaluated whether the recommended teicoplanin loading dose (3 loading doses of 10 mg/kg every 12 hours) achieves a 15-30 mu g/mL trough levels in 26 children (2-16 years). In addition, we examined the incidences of renal impairment and hepatic dysfunction in children treated with teicoplanin.
Methods: This retrospective study was conducted between October 2008 and March 2014.
Results: The percentage of patients with a trough level <10 and <15 mu g/mL were 15.4% (4/26) and 46.2% (12/26), respectively. There were significant correlations between age and concentration/cumulative loading dose (C/D) ratio (P = 0.045), serum creatinine and C/D ratio (P < 0.001) and estimated glomerular filtration rate and C/D ratio (P = 0.005). Serum creatinine was significantly lower when trough levels were < 15 mu g/mL compared with >= 15 mu g/mL. The incidences of renal impairment and hepatic dysfunction were 2.3% and 5.8%, respectively, with no significant difference between < 20 and >= 20 mu g/mL trough-level groups.
Conclusions: The recommended loading dose may be insufficient to achieve 15-30 mu g/mL in children with normal renal function. In addition, the target trough level >= 20 mu g/mL for deep-seated infections seems to be safe in children.
Methods: This retrospective study was conducted between October 2008 and March 2014.
Results: The percentage of patients with a trough level <10 and <15 mu g/mL were 15.4% (4/26) and 46.2% (12/26), respectively. There were significant correlations between age and concentration/cumulative loading dose (C/D) ratio (P = 0.045), serum creatinine and C/D ratio (P < 0.001) and estimated glomerular filtration rate and C/D ratio (P = 0.005). Serum creatinine was significantly lower when trough levels were < 15 mu g/mL compared with >= 15 mu g/mL. The incidences of renal impairment and hepatic dysfunction were 2.3% and 5.8%, respectively, with no significant difference between < 20 and >= 20 mu g/mL trough-level groups.
Conclusions: The recommended loading dose may be insufficient to achieve 15-30 mu g/mL in children with normal renal function. In addition, the target trough level >= 20 mu g/mL for deep-seated infections seems to be safe in children.
- リンク情報
- ID情報
-
- DOI : 10.1097/INF.0000000000001456
- ISSN : 0891-3668
- eISSN : 1532-0987
- PubMed ID : 27977550
- Web of Science ID : WOS:000396222900014