論文

国際誌
2020年9月3日

Markers for the central serotonin system correlate to verbal ability and paralinguistic social voice processing in autism spectrum disorder.

Scientific reports
  • Yuko Yoshimura
  • ,
  • Mitsuru Kikuchi
  • ,
  • Daisuke N Saito
  • ,
  • Tetsu Hirosawa
  • ,
  • Tetsuya Takahashi
  • ,
  • Toshio Munesue
  • ,
  • Hirotaka Kosaka
  • ,
  • Nobushige Naito
  • ,
  • Yasuomi Ouchi
  • ,
  • Yoshio Minabe

10
1
開始ページ
14558
終了ページ
14558
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-020-71254-w

Impairment in verbal communication abilities has been reported in autism spectrum disorder (ASD). Dysfunction of the serotonergic system has also been reported in ASD. However, it is still unknown how the brain serotonergic system relates to impairment in verbal communication abilities in individuals with ASD. In the present study, we investigated the correlation between brain serotonergic condition and brain sensitivity to paralinguistic stimuli (i.e., amplitude in the human voice prosodic change-evoked mismatch field) measured by magnetoencephalography (MEG) or verbal ability in 10 adults with ASD. To estimate the brain serotonergic condition, we measured the serotonin transporter nondisplaceable binding potential cerebrum-wide using positron emission tomography with [11C]N,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine ([11C] DASB). The results demonstrated a significant positive correlation between brain activity to paralinguistic stimuli and brain serotonin transporter binding potential in the left lingual gyrus, left fusiform gyrus and left calcarine cortex. In addition, there were significant positive correlations between verbal ability and serotonergic condition in the right anterior insula, right putamen and right central operculum. These results suggested that the occipital cortex is implicated in recognition of the prosodic change in ASD, whereas the right insula-involved serotonergic system is important in nurturing verbal function in ASD.Trial registration: UMIN000011077.

リンク情報
DOI
https://doi.org/10.1038/s41598-020-71254-w
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32883965
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471326
ID情報
  • DOI : 10.1038/s41598-020-71254-w
  • PubMed ID : 32883965
  • PubMed Central 記事ID : PMC7471326

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