Makishima Makoto

J-GLOBAL         Last updated: Apr 2, 2019 at 02:58
 
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Name
Makishima Makoto
E-mail
makishima.makotonihon-u.ac.jp
Affiliation
Nihon University
Section
School of Medicine, Department of Medicine, -
Job title
Professor
Degree
Ph.D.(Jichi Medical School)
Research funding number
70346146

Research Areas

 
 

Academic & Professional Experience

 
Jun 1987
 - 
May 1989
Resident, National Defense Medical College Hospital and Self Defense Force Central Hospital
 
Jun 1989
 - 
Jul 1991
Physician, Ground Self Defence Force Omiya Station
 
Aug 1991
 - 
Jul 1993
Fellow, Department of Internal Medicine III, National Defence Medical College
 
Aug 1993
 - 
Mar 1996
Staff Physician, Saitama Conprehensive Mental Health Center
 
Apr 1996
 - 
Mar 1998
Chief-in-Physician, Saitama Conprehensive Mental Health Center
 

Education

 
 
 - 
1987
Faculty of Medicine, National Defense Medical College
 

Published Papers

 
Unexpected emergence of luciferase-inhibitory activity during structural development study of phenyloxadiazole-based PPAR ligands
Ryuta Shioi, Yosuke Toyota, Tomomi Noguchi-Yachide, Minoru Ishikawa, Takao Yamaguchi, Makoto Makishima, Yuichi Hashimoto, and Kenji Ohgane
Heterocycles   in press   2018   [Refereed]
Shigeyuki Uno, Torahiko Tanaka, Hiroki Ashiba, Makoto Fujimaki, Mutsuo Tanaka, Yoshihiro Hatta, Masami Takei, Koichi Awazu, and Makoto Makishima
Journal of Bioscience and Bioengineering   126(1) 131-137   Jul 2018   [Refereed]
Abraham Neelankal John, Zafar Iqbal, Shane Colley, Grant Morahan, Makoto Makishima, and Fang-Xu Jiang
Diabetes & Metabolism   44(3) 269-280   Jun 2018   [Refereed]
ビタミンDの生理作用と作用メカニズム
槇島誠
食と医療   5 20-27   Apr 2018   [Invited]
Masaru Nakagawa, Sigeyuki Uno, Noriyoshi Iriyama, Manabu Matsunawa, Makoto Makishima, Jin Takeuchi, Isao Tsuboi, Yoshihiro Hatta, and Masami Takei
Toxicology and Applied Pharmacology   345 48-56   Apr 2018   [Refereed]

Misc

 
Kaori Endo-Umeda, Hiroyuki Nakashima, Shihoko Komine-Aizawa, Naoki Umeda, Shuhji Seki, and Makoto Makishima
Scientific Reports   18(1) 9281   Jun 2018   [Refereed]
脂質応答性核内受容体と大腸癌
槇島誠
肝胆膵   72(5) 839-836   May 2016   [Invited]
Ichiro Takada, and Makoto Makishima
Expert Opinion on Therapeutic Patents   25(12) 1373-1383   Dec 2015   [Refereed][Invited]
非セコステロイドビタミンD受容体作用薬とその治療応用への展望
槇島誠
Clinical Calcium   25(3) 403-411   Mar 2015   [Invited]
Takada, I., and Makishima, M.
Expert Opinion on Therapeutic Patents   25(2) 175-191   Feb 2015   [Refereed][Invited]

Books etc

 
Cooperative regulation of expression of cytochrome P450 enzymes by aryl hydrocarbon receptor and vitamin D receptor. In: Yamasaki H (ed), Fifty Years of Cytochrome P450 Research
Makoto Makishima (Part:Joint Work, 277-290)
Springer Japan   Jul 2014   ISBN:978-4431549918
The bile acid derivative lithocholic acid acetate and lithocholic acid propionate are functionally selective vitamin D receptor ligands. In: Feldman D., Pike JW, and Adams JS (eds), Vitamin D, third edition
Makishima M, and Yamada S (Part:Joint Work, 1509-1524)
Academic Press   Jun 2011   ISBN:978-0123870346
Nuclear receptors sense bile acid metabolism: A hormonal action of bile acids. In: Morikawa K, Tate S (eds), Functional and Structural Biology on the Lipo-network
Makishima M
Transworld Research Network   2006   ISBN:81-7895-232-7
核内レセプターによるコレステロール胆汁酸代謝調節. 食習慣を監視する分子メカニズム. 荒川泰行(編) 消化器病学の進歩 2005 ― モノグラフ ― 肝・胆・膵 編
槇島誠
日本消化器病学会   2005   
Vitamin D receptor as a bile acid sensor. In: Paumgartner P (ed), Falk Symposium. No. 129. Bile acids: From Genomics to Disease and Therapy
Lu, T. T., Makishima, M., and Mangelsdorf, D. J. (Part:Joint Work, 39-45)
Kluwer Academic Publishers   2003   ISBN:978-0792387817

Conference Activities & Talks

 
ビタミンD受容体の糞中胆汁酸代謝への関与
石澤通康、槇島誠
日本レチノイド研究会第28回学術集会   18 Nov 2017   
肝臓免疫細胞における核内受容体LXRの自然免疫調節作用
梅田(遠藤)香織、中島弘幸、梅田直、関修司、槇島誠
日本レチノイド研究会第28回学術集会   18 Nov 2017   
Phenanthridin-6(5H)-one骨格を有する非ステロイド型プロゲステロン受容体拮抗薬
西山郵子、森修一、槇島誠、藤井晋也、影近弘之、橋下祐一、石川稔
日本レチノイド研究会第28回学術集会   18 Nov 2017   
高脂肪食摂取マウスの胆汁酸代謝系におけるビタミンD受容体の関与
石澤通康、槇島誠
第39回胆汁酸研究会   11 Nov 2017   
腸管粘膜由来SW480細胞でのビタミンD依存性カルシウムチャネルTRPV6の発現誘導におけるp38とGADD45Aの関与
石澤通康、赤木大輔、山本純平、槇島誠.腸管粘膜由来SW480細胞でのビタミンD依存性カルシウムチャネルTRPV6の発現誘導におけるp38とGADD45Aの関与
第356回脂溶性ビタミン総合研究委員会   8 Sep 2017   

Patents

 
特願2007-147866 : 作用選択的ビタミンD受容体作用剤
特願2006-077193 : 神経突起伸長誘導剤
特願2003-115518 : コレステロール血症治療薬
特願2002-376589 : アディポネクチンプロモーターおよびその用途
特許出願平9-173408 : 9−シス−レチノイン酸−α−トコフェロールエステルを含有する白血病治療薬