2009年2月
Na,K-ATPase signal transduction triggers CREB activation and dendritic growth
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- 巻
- 106
- 号
- 7
- 開始ページ
- 2212
- 終了ページ
- 2217
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1073/pnas.0809253106
- 出版者・発行元
- NATL ACAD SCIENCES
Dendritic growth is pivotal in the neurogenesis of cortical neurons. The sodium pump, or Na,K-ATPase, is an evolutionarily conserved protein that, in addition to its central role in establishing the electrochemical gradient, has recently been reported to function as a receptor and signaling mediator. Although a large body of evidence points toward a dual function for the Na,K-ATPase, few biological implications of this signaling pathway have been described. Here we report that Na,K-ATPase signal transduction triggers dendritic growth as well as a transcriptional program dependent on cAMP response element binding protein ( CREB) and cAMP response element (CRE)-mediated gene expression, primarily regulated via Ca2+/calmodulin-dependent protein (CaM) kinases. The signaling cascade mediating dendritic arbor growth also involves intracellular Ca2+ oscillations and sustained phosphorylation of mitogen-activated protein (MAP) kinases. Thus, our results suggest a novel role for the Na,K-ATPase as a modulator of dendritic growth in developing neurons.
- リンク情報
- ID情報
-
- DOI : 10.1073/pnas.0809253106
- ISSN : 0027-8424
- PubMed ID : 19164762
- Web of Science ID : WOS:000263516100026