SAKAGUCHI Suehiro

J-GLOBAL         Last updated: Sep 13, 2019 at 10:46
 
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Name
SAKAGUCHI Suehiro
Affiliation
The University of Tokushima
Section
Graduate School of Biomedical Sciences

Education

 
Mar 1994
   
 
長崎大学 大学院医学研究科博士課程 修了
 

Awards & Honors

 
Jul 2013
Prions impair post-Golgi trafficking of membrane proteins, best presentation prize, Asian Pacific Prion Symposium 2013
Winner: Suehiro Sakaguchi
 

Published Papers

 
Roles of Prion Protein in Virus Infections.
Suehiro Sakaguchi, Junji Chida
DNA Cell Biol.   37(10) 808-811   Sep 2018   [Refereed]
Junji Chida, Hideyuki Hara, Masashi Yano, Keiji Uchiyama, Rani Nandita Das, Etsuhisa Takahashi, Hironori Miyata, Yukiko Tomioka, Toshihiro Ito, Hiroshi Kido, Suehiro Sakaguchi
PLoS Pathogens   Vol.14(No.5) e1007049-e1007049   May 2018   [Refereed]
The cellular prion protein, designated PrPC, is a membrane glycoprotein expressed abundantly in brains and to a lesser extent in other tissues. Conformational conversion of PrPC into the amyloidogenic isoform is a key pathogenic event in prion dis...
Hideyuki Hara, Miyata Hironori, Das Rani Nandita, Junji Chida, Yoshimochi Tatenobu, Keiji Uchiyama, Watanabe Hitomi, Kondoh Gen, Yokoyama Takashi, Suehiro Sakaguchi
Journal of Virology   Vol.92(No.1) pii:e01368-17-pii:e01368-17   Dec 2017   [Refereed]
Conformational conversion of the cellular isoform of prion protein, PrP, into the abnormally folded, amyloidogenic isoform, PrP, is a key pathogenic event in prion diseases, including Creutzfeldt-Jakob disease in humans and scrapie and bovine spon...
Keiji Uchiyama, Mitsuru Tomita, Masashi Yano, Junji Chida, Hideyuki Hara, Nandita Rani Das, Anders Nykjaer, Suehiro Sakaguchi
PLoS Pathogens   Vol.13(No.6) e1006470-e1006470   Jun 2017   [Refereed]
Prion diseases are a group of fatal neurodegenerative disorders caused by prions, which consist mainly of the abnormally folded isoform of prion protein, PrPSc. A pivotal pathogenic event in prion disease is progressive accumulation of prions, or ...
Das Rani Nandita, Miyata Hironori, Hideyuki Hara, Keiji Uchiyama, Junji Chida, Masashi Yano, Watanabe Hitomi, Kondoh Gen, Suehiro Sakaguchi
Archives of Virology   Vol.162(No.7) 1867-1876   Mar 2017   [Refereed]
The N-terminal polybasic region of the normal prion protein, PrP(C), which encompasses residues 23-31, is important for prion pathogenesis by affecting conversion of PrP(C) into the pathogenic isoform, PrP(Sc). We previously reported transgenic mi...

Misc

 
プリオン病における神経変性のメカニズム
Keiji Uchiyama, Suehiro Sakaguchi
Clinical Neuroscience   Vol.31(No.9) 1022-1024   Sep 2013
プリオン病
Suehiro Sakaguchi, Tsuyoshi Mori
Clinical Neuroscience   Vol.28(No.8) 906-908   Aug 2010
プリオン蛋白異常化と伝達・進行のメカニズム
Suehiro Sakaguchi
プリオン病と遅発性ウイルス感染症   37-43   Jul 2010
プリオン病予防ワクチンの開発の試み
Suehiro Sakaguchi
バイオ医薬の開発技術とシリーズ   373-384   Mar 2009
プリオン病と治療戦略の最近の動向
Suehiro Sakaguchi
BRAIN and NERVE   Vol.61(No.8) 929-938   2009

Books etc

 
シンプル微生物学(編集:小熊恵二,堀田博,若宮伸隆)
Suehiro Sakaguchi
Mar 2018   
Immunological strategies for the prevention and treatment of prion diseases.
Keiji Uchiyama, Suehiro Sakaguchi
Caister Academic Press   2013   
44章スローウイルスとプリオン
Suehiro Sakaguchi
丸善出版   Oct 2012   

Conference Activities & Talks

 
Prion protein protects mice from lethal infection with Influenza A virues
Junji Chida, Hideyuki Hara, Suehiro Sakaguchi
2017年度生命科学系学会合同年次大会 (ConBio2017) 第 40回日本分子生物学会年会/第90回日本 生化学会大会   8 Dec 2017   
Prion-infected neuroblastoma cells are resistant to influenza virus.
Hideyuki Hara, Junji Chida, Suehiro Sakaguchi
2017年度生命科学系学会合同年次大会 (ConBio2017) 第 40回日本分子生物学会年会/第90回日本 生化学会大会   7 Dec 2017   
High susceptibility of Sortilin-deficient cells to prion infection.
Keiji Uchiyama, Tomohiro Tohkoh, Suehiro Sakaguchi
第65回日本ウイルス学会学術集会   24 Oct 2017   
Identification and investigation of a novel anti-prion compound.
Keiji Uchiyama, Suehiro Sakaguchi
第65回日本ウイルス学会学術集会   24 Oct 2017   
Prion propagation through sortilin degradation.
Suehiro Sakaguchi, Keiji Uchiyama
第60回日本神経化学会大会   9 Sep 2017   

Research Grants & Projects

 
Grants-in-Aid for Scientific Research
Project Year: Jun 2017 - Mar 2019    Investigator(s): 坂口 末廣
Grants-in-Aid for Scientific Research
Project Year: Apr 2017 - Mar 2019    Investigator(s): 坂口 末廣
Grants-in-Aid for Scientific Research
Project Year: Apr 2015 - Mar 2017    Investigator(s): 坂口 末廣
Grants-in-Aid for Scientific Research
Project Year: Apr 2014 - Mar 2017    Investigator(s): SAKAGUCHI Suehiro