J-GLOBAL         Last updated: Jul 19, 2019 at 18:29
Nagasaki University
Graduate School of Biomedical Sciences, Medical and Dental Sciences
Job title
PhD(Osaka University)

Research Interests


Research Areas


Academic & Professional Experience

 Professor,Medical and Dental Sciences,Medical and Dental Sciences,Graduate School of Biomedical Sciences,Nagasaki University
 Researcher,National Institute of Health Japan
 Research Associate
 Visiting Researcher,Max-Plank Institute for Biology


Faculty of Dentistry, Osaka University

Committee Memberships

Japanese Society of Pediatric Dentistry  director

Awards & Honors

"LION AWARD", Japanese Society of Pediatric Dentistry

Published Papers

Porphyromonas gingivalis hydrogen sulfide enhances methyl mercaptan-induced pathogenicity in mouse abscess formation.
Nakamura S, Shioya K, Hiraoka BY, Suzuki N, Hoshino T, Fujiwara T, et al.
Microbiology and Immunology   523 119   Feb 2018   [Refereed]
Identification of a major glucose transporter in Flavobacterium johnsoniae: Inhibition of F. jonsoniae colony spreading by glucose uptake
Imamura K, Sato K, Narita Y, Kondo Y, Nakane D, Naito M, Fujiwara T. and Nakayama K
Microbiology and Immunology   62(8)    2018   [Refereed]
Involvement of PorK, a component of the type IX secretion system, in Prevotella melaninogenica pathogenicity.
Kondo Y, Sato, K, Nagano, Hoshino, T, Nishiguchi M, Fujiwara, T, and Nakayama, K.
Microbiology and Immunology   62(9)    2018   [Refereed]
Technique to Confirm Occlusal Contact Using an Articulating Paper Holder Equipped with Tongue Depressor" has been successfully submitted online and is presently being given full consideration for publication
N Tanoue, T Ayuse, T Fujiwara, T Ayuse
Journal of Prosthodontics      2018   [Refereed]
Long-term observation of a case of oculo-facio-cardio-dental syndrome that showed remarkable radioculomegaly of primary teeth
Nishiguchi M, Sasaki Y, Satoh K, Kamasaki Y, Kondo Y and FujiwaraT.
Journal of Translational Science   5(3) 1-4   2018   [Refereed]
Identification of a new subtype of dipeptidyl peptidase 11 and a third group of the S46-family members specifically present in the genus Bacteroides.
Nemoto TK, Bezerra GA, Ono T, Nishimata H, Fujiwara T, Ohara-Nemoto Y.
Biochimie   147 25-35   Oct 2017   [Refereed]
Draft Genome Sequence of a Clinical Isolate of Streptococcus mutans Strain HM
Kondo Y, Nishimata H, Hidaka K, Hasuwa T, Moriuchi H, Fujiwara T, et al
Genome Announc   5(33) e00826–17   Aug 2017   [Refereed]
Acute oral complications in a pediatric patient with acute lymphoid leukemia
Kamasaki Y, Satoh K, Nishiguchi M, Hoshino T, Fujiwara T.
Pediatr Int.   58(6) 484-487   May 2016   [Refereed]
Identification of Dipeptidyl-Peptidase (DPP)5 and DPP7 in Porphyromonas endodontalis, Distinct from Those in Porphyromonas gingivalis.
Nishimata H, Ohara-Nemoto Y, Baba T, Hoshino T, Fujiwara T, Shimoyama Y, et al.
PLOS ONE   9(12) e114221   Sep 2014   [Refereed]
Presurgical growth guidance with Naso-alveolar molding in infants with cleft lip and palate
43(1) 112-118   2007   [Refereed][Invited]
Ikuri Konishi, Satoshi Fukumoto, Aya Yamada, Kazuaki Nonaka, Taku Fujiwara
Pediatric Dental Journal   15(1) 143-146   2005   [Refereed]
Synergistic effects of streptococcal glucosyltransferases on adhesive biofilm formation
83(11) 874-879   2004   [Refereed]
Infection by Streptococcus pyogenes induces the receptor activator of NF-kappaB ligand expression in mouse osteoblastic cells
71(2) 948-955   2003   [Refereed]
The role of glucan-binding proteins in the cariogenicity of Streptococcus mutans
47(3) 213-215   2003   [Refereed]
Differential and quantitative analyses of mRNA expression of glucosyltransferases from Streptococcus mutans MT8148
81(2) 1093-113   2002   [Refereed]
Attenuation of glucan-binding protein C reduces the cariogenicity of Streptococcus mutans: analysis of strains isolated from human blood
81(6) 376-379   2002   [Refereed]
Dentin matrix protein 1 is predominantly expressed in chicken and rat osteocytes, but not osteoblasts. 
16(11) 2017-2026   2001   [Refereed]
Contributions of three glycosyltransferases to sucrose-dependent adherence of Streptococcus mutans
Ooshima T., Matsumura M., Hoshino T., Kawabata S., Sobue S. ,Fujiwara T.
J Dent Res   80(7) 1672-1677   2001
Biochemical and genetic characterization of serologically untypable Streptococcus mutans strains isolated from patients with bacteremia
109(5) 330-334   2001   [Refereed]
Dentin matrix protein 1 is predominantly expressed in chicken and rat osteocytes but not in osteoblasts
16(11) 2017-2026   2001   [Refereed]
Induction of experimental periodontitis in mice with Porphyromonas gingivalis-adhered ligatures
71(7) 1167-1173   2000   [Refereed]
Gene   256(1/2) 1-11   2000   [Refereed]
Simultaneous occurrence of unusual odontodysplasia and oligodontia in the permanent dentition: report of a case
10(4) 341-347   2000   [Refereed]
Targeted salivary gland immunization with plasmid DNA elicits specific salivary immunoglobulin A and G antibodies and serum immunoglobulin G antibodies in mice
67(11) 5863-5868   1999   [Refereed]
Comparison of the cariostatic effects between regimens to administer oolong tea polyphenols in SPF rats
32(1) 75-80   1998   [Refereed]
FEMS Microbiology Letters   161(2) 331-336   1998   [Refereed]
Porphyromonas gingivalis lipopolysaccharide modulates the responsiveness of human periodontal ligament fibroblasts to platelet-derived growth factor
33(7) 400-407   1998   [Refereed]
Modification of sucrose dependent cell adherence by deletion and reintroduction of the gtf genes in Streptococcus mutans
418 665-668   1997   [Refereed]
Prophyromonas gingivalis fimbriae mediate coaggregation with Streptococcus oralis through specific domains
76(4) 852-857   1997   [Refereed]
Cysteine protease of Porphyromonas gingivalis 381 enhances binding of fimbriae to cultured human fibroblasts and matrix proteins
64(3) 756-762   1996   [Refereed]
Molecular and immunological characterization of the fimbriae of Porphyromonas gingivalis
38(12) 921-930   1994   [Refereed]
Effects of selected surfactants on purified glucosyltransferases from mutans streptococci and cellular adherence to smooth surfaces
38(1) 54-60   1993   [Refereed]
Oolong tea polyphenols inhibit experimental dental caries in SPF rats infected with mutans streptococci
27(2) 124-129   1993   [Refereed]
Noncariogenicity of maltitol in specific pathogen-free rats infected with mutans streptococci
26(1) 33-37   1992   [Refereed]
Latex agglutination test for detection of mutans streptococci in relation to dental caries in children
37(2) 99-104   1992   [Refereed]
Biochemical and Biophysical Research Communications   187(3) 1432-1438   1992   [Refereed]
Dental caries induction in hyposalivated rats
25(2) 138-142   1991   [Refereed]
Trehalulose does not induce dental caries in rats infected with mutans streptococci
25(4) 277-282   1991   [Refereed]
Caries prevalence and salivary mutans streptococci in 0-2-year-old children of Japan
19(3) 151-154   1991   [Refereed]
Oral passive immunization against dental caries in rats by use of hen egg yolk antibodies specific for cell-associated glucosyltransferase of Streptococcus mutans
59(11) 4161-4167   1991   [Refereed]
Plaque formation of dietary isomaltulose in humans
24(1) 48-51   1990   [Refereed]
Chemical, immunobiological and antigenic characterizations of lipopolysaccharides from Bacteroides gingivalis strains
136(2) 319-326   1990   [Refereed]
Lipopolysaccharides of oral anaerobes associated with chronic inflammation: chemical and immunomodulating properties
6(4) 247-261   1990   [Refereed]
Effect of experimental hyposalivation on the induction of dental caries in rats infected with Streptococcus mutans
24(6) 446-451   1990   [Refereed]
Bacteroides lipopolysaccharides (LPS) induce anaphylactoid and lethal reactions in LPS-responsive and -nonresponsive mice primed with muramyl dipeptide
162(2) 428-434   1990   [Refereed]
Interaction of structural isomers of sucrose in the reaction between sucrose and glucosyltransferases from mutans streptococci
5(4) 189-194   1990   [Refereed]
Antimicrobial activities of thiolactomycin against gram-negative anaerobes associated with periodontal disease.
5(6) 340-345   1990   [Refereed]
Minami T., Miki T., Fujiwara T., Kawabata S., Izumitani A., Ooshima T., Sobue S. ,Hamada S.
Jap J Ped Dent   27(4) 1010-1017   1989   [Refereed]
Izumitani A., Fujiwara T., Minami T., Suzuki S., Ooshima T. ,Sobue S.
Jap J Ped Dent   27(4) 1018-1024   1989   [Refereed]
Effects of panose on glucan synthesis and cellular adherence by Streptococcus mutans
32(1) 25-31   1988   [Refereed]
Immunobiological properties of lipopolysaccharides isolated from Fusobacterium nucleatum and F. necrophorum
134(6) 1707-1715   1988   [Refereed]
Fujiwara T., Takei T., Kohno H., Sasada E., Izumitani A., Ooshima T. ,Sobue S.
Jap J Ped Dent   26(3) 556-563   1988   [Refereed]
Yoshida I., Fujiwara T., Ooshima T. ,Sobue S.
Jap J Ped Dent   26(4) 782-789   1988   [Refereed]
Characterization and immunobiologic activities of lipopolysaccharides from periodontal bacteria
2(2) 284-291   1988   [Refereed]
Serological properties and immunobiological activities of lipopolysaccharides from black-pigmented and related oral Bacteroides species
134(11) 2867-2876   1988   [Refereed]
Selection induction of prostaglandin E production in C3H/HeJ mouse macrophages by lipopolysaccharides from Bacteroides gingivalis
3(4) 196-198   1988   [Refereed]
Fujiwara T., Takei T., Izumitani A., Ooshima T. ,Sobue S.
Jap J Ped Dent   25(3) 608-613   1987   [Refereed]
Local Shwartzman activity of lipopolysaccharides from several selected strains of suspected periodontopathic bacteria
22(2) 103-107   1987   [Refereed]
Izumitani A., Fujiwara T., Yasufuku Y., Ooshima T. ,Sobue S.
Jap J Ped Dent   24(4) 751-757   1986   [Refereed]
Chemical composition and immunobiological properties of lipopolysaccharide and lipid-associated proteoglycan from Actinobacillus actinomycetemcomitans
21(5) 521-530   1986   [Refereed]
Biochemical and immunobiological properties of lipopolysaccharide (LPS) from Bacteroides gingivalis and comparison with LPS from Escherichia coli
47(3) 638-647   1985   [Refereed]


Etiology and clinical symptoms of Dental Caries
Fujiwara T.
210(4) 305-316   2005

Books etc

Compendium on Oral Health of Children around the World: Early Childhood Caries.
Hoshino T, Fujiwara T (Part:Contributor, Chapter JAPAN)
Nova publishers   Feb 2018   
Pediatric Dentistry 3rd edition
Ishiyaku Syuppan   2007   

Conference Activities & Talks

Preventive Strategies and Fluoride Protocols [Invited]
IAPD Global Summit on Early Childhood Caries   3 Nov 2018   
Current status of dental caries of preschool children in Japan [Invited]
16 Sep 2018   
Is human-milk lactose pathogen of the nursing caries? [Invited]
26th IAPD Congress,   Oct 2017   
Infective endocarditis and dental treatment

Research Grants & Projects

Molecularbiological analysis of the pathogenic factor of cariogenic bacteria
Establishment of oral microflora
The gene of tooth formation and genetic diagnosis of the formation disorder of the tooth.