2001年2月
Establishment of gene-vaccinated skin grafting against Toxoplasma gondii infection in mice
VACCINE
- 巻
- 19
- 号
- 15-16
- 開始ページ
- 2172
- 終了ページ
- 2180
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S0264-410X(00)00366-2
- 出版者・発行元
- ELSEVIER SCI LTD
Vaccine effects of in vivo gene-vaccinated skin graft were evaluated against Toxoplasma gondii (T. gondii) infection. By using a gene gun, cDNA coding T. gondii SAG1 molecule was intracutaneously vaccinated into C57BL/6 (B6; a susceptible strain), BALB/c (a resistant strain) and (C57BL/6 x BALB/c) F1 (CBF1) mice, and the gene- vaccinated skin of these strains was transplanted to CBF1 mice. Regarding the antibody production against SAG1, CBF1-recipient mice transplanted with the SAG1 gene-vaccinated B6 skin were high responders, whereas CBF1 mice skin grafted with vaccinated skin of both BALB/c and CBF1 mice were low responders. The donor-derived LC/DC migrated to the draining lymph nodes of the recipients from the skin graft within 3 days. The vaccine effect against T. gondii challenge infection was obtained in CBF1 mice which received the skin graft of the SAG1 gene-vaccinated BALB/c mice. (C) 2001 Elsevier Science Ltd. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/S0264-410X(00)00366-2
- ISSN : 0264-410X
- Web of Science ID : WOS:000167538200039