MISC

2001年5月

Protective immunity to Schistosoma japonicum infection depends on the balance of T helper cytokine responses in mice vaccinated with gamma-irradiated cercariae

PARASITE IMMUNOLOGY
  • Y Osada
  • ,
  • T Janecharut
  • ,
  • H Hata
  • ,
  • Y Mahakunkij-Charoen
  • ,
  • XW Chen
  • ,
  • T Nara
  • ,
  • K Kita
  • ,
  • S Kojima

23
5
開始ページ
251
終了ページ
258
記述言語
英語
掲載種別
DOI
10.1046/j.1365-3024.2001.00379.x
出版者・発行元
BLACKWELL SCIENCE LTD

Although the strain difference in protection of mice to Schistosoma mansoni infection has been described, limited information is available in the case of Schistosoma japonicum In the present study, we compared the protective immunity to S. japonicum infection and cytokine production in various strains of mice vaccinated with gamma -irradiated cercariae. A significant reduction in worm recovery was observed in male and female mice of DBA/2 at a 6-week interval between vaccination and a challenge infection, whereas vaccinated mice of C57BL/6, C57BL/10, (C57BL/6 x DBA/2) F1 (B6D2F1) and (C57BL/ 10 x DBA/2) FI (B10D2F1) showed no detectable level of protection. No sex-linked difference in development of resistance was observed in any of the strains so far examined. Vaccination with gamma -irradiated cercariae twice with a 3-week interval also induced significant protection against a challenge infection in DBA/2 but not in BALB/c or C57BL/6 strains. Further studies demonstrated that spleen cells of vaccinated C57BL/6 mice produced lower levels of IFN-gamma compared to the cells of vaccinated BALB/c and DBA/2. On the other hand, production of IL-10 by spleen cells was relatively higher in BALB/c mice than in the other two strains. Macrophages that had been stimulated with spleen cell culture supernatants derived from vaccinated DBA/2 damaged schistosomula more effectively than cells stimulated with supernatants derived from the other strains. These results suggest that different levels of protection observed among strains of mice depend on the balance of cytokine responses which consequently activate or suppress macrophage-mediated damage to schistosomula.

リンク情報
DOI
https://doi.org/10.1046/j.1365-3024.2001.00379.x
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000168688900004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1046/j.1365-3024.2001.00379.x
  • ISSN : 0141-9838
  • Web of Science ID : WOS:000168688900004

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