Kiyotsugu Yoshida

Profile Information

Affiliation: Porfessor, Dept. of Biochemistry, Jikei University

J-GLOBAL ID: 200901057430319957
researchmap Member ID: 5000036278

Research Areas

Life sciences / Tumor biology /

Research History

Apr, 2012 - Present

Professor, Dept. of Biochemistry, Jikei University
Apr, 2007 - Mar, 2012

Medical Research Institute, Tokyo Medical and Dental University
Dec, 2005 - Mar, 2007

Medical Research Institute, Tokyo Medical and Dental University
Jul, 2002 - Nov, 2005

Medical Research Institute, Tokyo Medical and Dental University
Oct, 2000 - Jun, 2002

Instructor, Dana Farber Cancer Institute
May, 1996 - Sep, 2000

Research Associate, Dana Farber Cancer Institute

Education

Apr, 1993 - Oct, 1997

医学研究科博士課程, 東京慈恵会医科大学大学院
Apr, 1987 - Mar, 1993

医学部, 東京慈恵会医科大学

Papers

Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor effects by induction of G1 arrest in lung adenocarcinoma.

Eriko Harada, Saishu Yoshida, Yuta Imaizumi, Akira Kawamura, Takashi Ohtsuka, Kiyotsugu Yoshida

Biochimica et biophysica acta. General subjects, 1868(6) 130600-130600, Mar 18, 2024
Protein kinase C delta enhances the diagnostic performance of hepatocellular carcinoma.

Chika Nakagawa, Tsunekazu Oikawa, Kohji Yamada, Akihito Tsubota, Chisato Saeki, Kuniko Katagiri, Naoko Tago, Hiroshi Kamioka, Kaoru Ueda, Koichiro Haruki …

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 1-13, Feb 15, 2024
DYRK2 promotes chemosensitivity via p53-mediated apoptosis after DNA damage in colorectal cancer.

Yasuhiro Takano, Satomi Yogosawa, Yuta Imaizumi, Hiroshi Kamioka, Yumi Kanegae, Ken Eto, Kiyotsugu Yoshida

Cancer science, Sep 30, 2023
Dyrk2 gene transfer suppresses hepatocarcinogenesis by promoting the degradation of Myc and Hras.

Hiroshi Kamioka, Satomi Yogosawa, Tsunekazu Oikawa, Daisuke Aizawa, Kaoru Ueda, Chisato Saeki, Koichiro Haruki, Masayuki Shimoda, Toru Ikegami, Yuji Nishikawa …

JHEP reports : innovation in hepatology, 5(7) 100759-100759, Jul, 2023
Extended-Synaptotagmin 1 Enhances Liver Cancer Progression Mediated by the Unconventional Secretion of Cytosolic Proteins.

Kohji Yamada, Yoshito Hannya, Tsunekazu Oikawa, Ayano Yoshida, Kuniko Katagiri, Saishu Yoshida, Rei Koizumi, Naoko Tago, Yuya Shimoyama, Akira Kawamura …

Molecules (Basel, Switzerland), 28(10), May 11, 2023
Inhibition of protein kinase C delta leads to cellular senescence to induce anti-tumor effects in colorectal cancer.

Yuya Shimoyama, Kohji Yamada, Saishu Yoshida, Akira Kawamura, Yoshito Hannya, Yuta Imaizumi, Tomotaka Kumamoto, Yasuhiro Takeda, Masayuki Shimoda, Ken Eto …

Cancer science, 114(6) 2471-2484, Feb 27, 2023
Protein Kinase C Delta Is a Novel Biomarker for Hepatocellular Carcinoma

Tsunekazu Oikawa, Kohji Yamada, Akihito Tsubota, Chisato Saeki, Naoko Tago, Chika Nakagawa, Kaoru Ueda, Hiroshi Kamioka, Tomohiko Taniai, Koichiro Haruki …

Gastro Hep Advances, 2(1) 83-95, 2023
Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B+ vesicle pathway in liver cancer.

Kohji Yamada, Saya Motohashi, Tsunekazu Oikawa, Naoko Tago, Rei Koizumi, Masaya Ono, Toshiaki Tachibana, Ayano Yoshida, Saishu Yoshida, Masayuki Shimoda …

Proceedings of the National Academy of Sciences of the United States of America, 119(36) e2202730119, Sep 6, 2022
細胞外PKCδはEGF受容体と結合して肝細胞がんの増殖に寄与する(Extracellular PKCδ associates with EGF receptor for liver cancer proliferation)

吉田彩乃, 山田幸司, 及川恒一, 小泉麗, 吉田彩舟, 吉田清嗣

日本癌学会総会記事, 81回 J-1037, Sep, 2022
DYRK2 maintains genome stability via neddylation of cullins in response to DNA damage.

Akira Kawamura, Saishu Yoshida, Katsuhiko Aoki, Yuya Shimoyama, Kohji Yamada, Kiyotsugu Yoshida

Journal of cell science, May 18, 2022
Extracellular PKCδ signals to epidermal growth factor receptor for tumor proliferation in liver cancer cells.

Kohji Yamada, Ryusuke Kizawa, Ayano Yoshida, Rei Koizumi, Saya Motohashi, Yuya Shimoyama, Yoshito Hannya, Saishu Yoshida, Tsunekazu Oikawa, Masayuki Shimoda …

Cancer science, 113(7) 2378-2385, May 1, 2022
Enforced dual-specificity tyrosine-regulated kinase 2 expression by adenovirus-mediated gene transfer inhibits tumor growth and metastasis of colorectal cancer.

Yuta Imaizumi, Saishu Yoshida, Yumi Kanegae, Ken Eto, Kiyotsugu Yoshida

Cancer science, 113(3) 960-970, Mar, 2022
New insights into the roles for DYRK family in mammalian development and congenital diseases

Genes & Diseases, 2022 Peer-reviewed
Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient

Satomi Yogosawa, Makiko Ohkido, Takuro Horii, Yasumasa Okazaki, Jun Nakayama, Saishu Yoshida, Shinya Toyokuni, Izuho Hatada, Mitsuru Morimoto, Kiyotsugu Yoshida

Communications Biology, 4(1), Dec, 2021
Unconventional Secretion of PKCδ Exerts Tumorigenic Function via Stimulation of ERK1/2 Signaling in Liver Cancer.

Kohji Yamada, Tsunekazu Oikawa, Ryusuke Kizawa, Saya Motohashi, Saishu Yoshida, Tomotaka Kumamoto, Chisato Saeki, Chika Nakagawa, Yuya Shimoyama, Katsuhiko Aoki …

Cancer research, 81(2) 414-425, Jan 15, 2021
PKCδ deficiency inhibits fetal development and is associated with heart elastic fiber hyperplasia and lung inflammation in adult PKCδ knockout mice.

Yuko S Niino, Ikuo Kawashima, Yoshinobu Iguchi, Hiroaki Kanda, Kiyoshi Ogura, Kaoru Mita-Yoshida, Tomio Ono, Maya Yamazaki, Kenji Sakimura, Satomi Yogosawa …

PloS one, 16(7) e0253912, 2021
Carbonic anhydrase 13 suppresses bone metastasis in breast cancer.

Satomi Yogosawa, Jun Nakayama, Mayuko Nishi, Akihide Ryo, Kiyotsugu Yoshida

Cancer treatment and research communications, 27 100332-100332, 2021
The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.

Saishu Yoshida, Katsuhiko Aoki, Ken Fujiwara, Takashi Nakakura, Akira Kawamura, Kohji Yamada, Masaya Ono, Satomi Yogosawa, Kiyotsugu Yoshida

eLife, 9, Aug 6, 2020
Impairment of DYRK2 by DNMT1‑mediated transcription augments carcinogenesis in human colorectal cancer.

Tomotaka Kumamoto, Kohji Yamada, Saishu Yoshida, Katsuhiko Aoki, Shinichi Hirooka, Ken Eto, Katsuhiko Yanaga, Kiyotsugu Yoshida

International journal of oncology, 56(6) 1529-1539, Jun, 2020
Clinical implications of drug-screening assay for recurrent metastatic hormone receptor-positive, human epidermal receptor 2-negative breast cancer using conditionally reprogrammed cells.

Rei Mimoto, Satomi Yogosawa, Hiroki Saijo, Atsushi Fushimi, Hiroko Nogi, Tadashi Asakura, Kiyotsugu Yoshida, Hiroshi Takeyama

Scientific reports, 9(1) 13405-13405, Sep 16, 2019

Misc.

Leakage? or Secretion? unconventional protein secretion in cancer

Kohji Yamada, Kiyotsugu Yoshida

Oncotarget, 14(1) 146-147, Jan 12, 2023
早期診断に有用な肝細胞癌特異的バイオマーカー血清PKCδ

及川恒一, 山田幸司, 坪田昭人, 佐伯千里, 上田薫, 神岡洋, 春木孝一郎, 池上徹, 吉田清嗣, 猿田雅之

肝細胞研究会プログラム・抄録集, 30th, 2023
Multiple subcellular localizations and functions of protein kinase Cδ in liver cancer.

Kohji Yamada, Kiyotsugu Yoshida

World journal of gastroenterology, 28(2) 188-198, Jan 14, 2022
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena …

Autophagy, 17(1) 1-382, Jan, 2021
Multiple functions of DYRK2 in cancer and tissue development.

Saishu Yoshida, Kiyotsugu Yoshida

FEBS letters, 593(21) 2953-2965, Nov, 2019
Mechanical insights into the regulation of programmed cell death by p53 via mitochondria.

Kohji Yamada, Kiyotsugu Yoshida

Biochimica et biophysica acta. Molecular cell research, 1866(5) 839-848, May, 2019
Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis.

Satomi Yogosawa, Kiyotsugu Yoshida

Cancer science, 109(11) 3376-3382, Nov, 2018
The functional role for condensin in the regulation of chromosomal organization during the cell cycle.

Yuya Kagami, Kiyotsugu Yoshida

Cellular and molecular life sciences : CMLS, 73(24) 4591-4598, Dec, 2016
Crosstalk between tumor suppressors p53 and PKCδ: Execution of the intrinsic apoptotic pathways.

Nurmaa Dashzeveg, Kiyotsugu Yoshida

Cancer letters, 377(2) 158-63, Jul 28, 2016
Cell death decision by p53 via control of the mitochondrial membrane.

Nurmaa Dashzeveg, Kiyotsugu Yoshida

Cancer letters, 367(2) 108-12, Oct 28, 2015
Engagement of DYRK2 in proper control for cell division.

Naoe Taira Nihira, Kiyotsugu Yoshida

Cell cycle (Georgetown, Tex.), 14(6) 802-7, 2015
DYRK2はSnailをリン酸化し乳がんの浸潤・転移を制御する(DYRK2 phosphorylates Snail and regulates the invasion and metastasis in breast cancer)

三本麗, 山口乃里子, 平直江, 鷹橋浩幸, 三木義男, 吉田清嗣

日本癌学会総会記事, 71回 88-88, Aug, 2012
DYRK2の発現欠失によるc-Jun/c-Mycの制御異常は細胞の腫瘍化を引き起こす(Dysregulation of c-Jun/c-Myc expression by depletion of DYRK2 triggers tumorigenesis)

平直江, 三本麗, 倉田盛人, 北川昌伸, 三木義男, 吉田清嗣

日本癌学会総会記事, 71回 71-71, Aug, 2012
DYRK2はsnail/E-cadherin系を介して癌の浸潤を制御する(DYRK2 regulates cancer invasiveness via Snail/E-cadherin pathway)

三本麗, 平直江, 鷹橋浩之, 内田賢, 三木義男, 吉田清嗣

日本癌学会総会記事, 70回 78-78, Sep, 2011
DYRK2によるc-Jun/c-Mycのリン酸化は細胞周期G1/S期の進行を制御する(DYRK2-mediated phosphorylation of c-Jun and c-Myc is required for proper control of the G 1/S transition)

平直江, 三本麗, 倉田盛人, 北川昌伸, 三木義男, 吉田清嗣

日本癌学会総会記事, 70回 99-99, Sep, 2011
DYRK2は転写因子c-Jun/c-Mycへのリン酸化を介して細胞周期G1/S期の進行を制御する(DYRK2 regulates the G1/S transition by phosphorylation of c-Jun and c-Myc)

平直江, 三本麗, 倉田盛人, 北川昌伸, 三木義男, 吉田清嗣

日本癌学会総会記事, 69回 373-374, Aug, 2010
The cell death machinery governed by the p53 tumor suppressor in response to DNA damage.

Kiyotsugu Yoshida, Yoshio Miki

Cancer science, 101(4) 831-5, Apr, 2010
Pim-1はRelA/p65のSer276をリン酸化することでNF-κBの活性化を制御する(Pim-1 kinase controls the transcription activity of NF-kappaB through phosphorylation of the RelA/p65 subunit at Ser276)

仁平啓史, 三木義男, 吉田清嗣

日本癌学会総会記事, 68回 368-368, Aug, 2009
ATMによるDYRK2のリン酸化はMDM2を介したユビキチン化の阻害に必要である(ATM phosphorylation of DYRK2 confers resistance to ubiquitination-mediated degradation by MDM2)

平直江, 三木義男, 吉田清嗣

日本癌学会総会記事, 68回 401-401, Aug, 2009
Role for DYRK family kinases on regulation of apoptosis.

Kiyotsugu Yoshida

Biochemical pharmacology, 76(11) 1389-94, Dec 1, 2008

Presentations

大腸がんに対するアデノウイルスベクターによるDYRK2過剰発現を用いた新規遺伝子治療

今泉佑太, 吉田彩舟, 青木勝彦, 鐘ヶ江裕美, 吉田清嗣, 大木隆生

日本外科学会定期学術集会抄録集, Apr, 2021, (一社)日本外科学会
肝臓癌におけるDYRK2の強制発現はアポトーシスを介して抗腫瘍効果を発揮する

横山志保, 與五沢里美, 鐘ヶ江裕美, 吉田彩舟, 及川恒一, 猿田雅之, 吉田清嗣

東京慈恵会医科大学雑誌, Nov, 2019, 東京慈恵会医科大学成医会
DNA Methylation of Dual-Specificity Tyrosine-Regulated Kinase 2 (DYRK2) Promoter Regulates Proliferation of Human Colorectal Cancer

Tomotaka Kumamoto, Kohji Yamada, Saishu Yoshida, Katsuhiko Aoki, Katsuhiko Yanaga, Kiyotsugu Yoshida

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, Oct, 2019, ELSEVIER SCIENCE INC
DYRK2のメチル化を標的とした大腸癌治療の可能性

隈本智卓, 山田幸司, 青木勝彦, 吉田清嗣, 矢永勝彦

日本消化器外科学会総会, Jul, 2019, (一社)日本消化器外科学会
DYRK2のプロモーター領域のメチル化はヒトの結腸直腸癌の進行を制御する(DNA methylation of DYRK2 promoter regulates progression of human colorectal cancer)

隈本智卓, 山田幸司, 青木勝彦, 矢永勝彦, 吉田清嗣

日本癌学会総会記事, Sep, 2018, (一社)日本癌学会
CR細胞を用いたルミナルB乳癌に対する新たな薬剤感受性試験法の確立(Conditional reprogramming cells are novel tools for drug response assay in Luminal B breast cancer)

三本麗, 與五沢里美, 伏見淳, 野木裕子, 武山浩, 吉田清嗣, 大木隆生

日本癌学会総会記事, Sep, 2018, (一社)日本癌学会
DYRK2 Regulates EMT through Snail degradation in ovarian serous adenocarcinoma

Nov 15, 2014
卵巣漿液性腺癌におけるDYRK2を介した転移メカニズムの解明

山口乃里子, 矢内原臨, 三本麗, 井廻良美, 上田和, 平田幸広, 斉藤美里, 岡本愛光, 吉田清嗣

東京慈恵会医科大学雑誌, Nov, 2014, 東京慈恵会医科大学成医会
卵巣漿液性腺癌におけるDYRK2を介した転移・浸潤メカニズムの解明(DYRK2 Regulates EMT through Snail Degradation in Ovarian Serous Adenocarcinoma)

山口乃里子, 三本麗, 上田和, 仁平直江, 矢内原臨, 岡本愛光, 吉田清嗣

日本癌学会総会記事, Sep, 2014, 日本癌学会
卵巣漿液性腺癌におけるDYRK2を介した転移・浸潤メカニズムの解明

山口乃里子, 矢内原臨, 平田幸広, 斉藤美里, 吉田清嗣, 岡本愛光

日本産科婦人科学会雑誌, Feb, 2014, (公社)日本産科婦人科学会
P2-55-5 卵巣漿液性腺癌におけるDYRK2を介した転移・浸潤メカニズムの解明(Group 93 卵巣腫瘍・基礎4,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)

山口乃里子, 矢内原臨, 平田幸広, 斉藤美里, 吉田清嗣, 岡本愛光

日本産科婦人科學會雜誌, 2014, 日本産科婦人科学会
DYRK2 regulates breast cancer invasion via Snail/E-cadherin pathway

R. Mimoto, Y. Imawari, M. Kamio, K. Kato, H. Nogi, Y. Toriumi, H. Takeyama, K. Yoshida, K. Uchida

CANCER RESEARCH, Dec, 2012, AMER ASSOC CANCER RESEARCH
DYRK2はSnailをリン酸化し乳がんの浸潤・転移を制御する(DYRK2 phosphorylates Snail and regulates the invasion and metastasis in breast cancer)

三本麗, 山口乃里子, 平直江, 鷹橋浩幸, 三木義男, 吉田清嗣

日本癌学会総会記事, Aug, 2012, 日本癌学会
DYRK2の発現欠失によるc-Jun/c-Mycの制御異常は細胞の腫瘍化を引き起こす(Dysregulation of c-Jun/c-Myc expression by depletion of DYRK2 triggers tumorigenesis)

平直江, 三本麗, 倉田盛人, 北川昌伸, 三木義男, 吉田清嗣

日本癌学会総会記事, Aug, 2012, 日本癌学会
癌抑制遺伝子産物p53によるアポトーシス関連遺伝子の探索(Discovery of the pro-apoptotic genes induced by the tumor suppressor p53)

ダシゼウェゲ・ヌルマ, 平直江, 木村純子, 三木義男, 吉田清嗣

日本癌学会総会記事, Sep, 2011, 日本癌学会
DYRK2によるc-Jun/c-Mycのリン酸化は細胞周期G1/S期の進行を制御する(DYRK2-mediated phosphorylation of c-Jun and c-Myc is required for proper control of the G 1/S transition)

平直江, 三本麗, 倉田盛人, 北川昌伸, 三木義男, 吉田清嗣

日本癌学会総会記事, Sep, 2011, 日本癌学会
DYRK2はsnail/E-cadherin系を介して癌の浸潤を制御する(DYRK2 regulates cancer invasiveness via Snail/E-cadherin pathway)

三本麗, 平直江, 鷹橋浩之, 内田賢, 三木義男, 吉田清嗣

日本癌学会総会記事, Sep, 2011, 日本癌学会
DYRK2は転写因子c-Jun/c-Mycへのリン酸化を介して細胞周期G1/S期の進行を制御する(DYRK2 regulates the G1/S transition by phosphorylation of c-Jun and c-Myc)

平直江, 三本麗, 倉田盛人, 北川昌伸, 三木義男, 吉田清嗣

日本癌学会総会記事, Aug, 2010, 日本癌学会
新規p53応答遺伝子D4S234EはDNA損傷下において小胞輸送を介してアポトーシスを誘導する(D4S234E, a novel p53-responsive gene, induces apoptosis via the ER trafficking in response to DNA damage)

三本麗, 木村純子, 三木義男, 吉田清嗣

日本癌学会総会記事, Aug, 2010, 日本癌学会
ATMによるDYRK2のリン酸化はMDM2を介したユビキチン化の阻害に必要である(ATM phosphorylation of DYRK2 confers resistance to ubiquitination-mediated degradation by MDM2)

平直江, 三木義男, 吉田清嗣

日本癌学会総会記事, Aug, 2009, 日本癌学会

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