SUMO (small ubiquitin-like protein), one of the ubiquitin-like proteins, functions as a posttranslational modification system by binding with various proteins with covalent bond similar to ubiquitin system such as E1, E2, E3. Before starting this ...
The purpose of this study was to clarify the mechanism for the onset of hyperuricemia and to develop a novel uricosuric drug targeting renal urate transporters by analyzing transgenic mice of urate efflux transporter URATv1 that expresses at the b...
In the kidney, prostaglandins (PGs), especially prostaglandin E_2(PGE_2), have important roles in renal hemodynamics, renin release, tubular sodium and water reabsorption. Because PGs are charged organic anions at physiological pH, they poorly pen...
Based on our preliminary results that the identification of intracellular binding protein PDZK1 for renal urate transporter URAT1 by yeast two-hybrid (Y2H) screening, we were planning to extend this research to clarify the functional regulatory me...
Identification of intracellular binding proteins for organic ion transporters
Basic Research Promotion Service for Health and Medical Field
