YOSHIOKA Kazuaki

J-GLOBAL         Last updated: Oct 28, 2019 at 19:54
 
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Name
YOSHIOKA Kazuaki
Affiliation
Kanazawa University
Section
Institute of Medical,Pharmaceutical and Health Sciences, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine
ORCID ID
0000-0002-8631-3846

Research Areas

 
 

Academic & Professional Experience

 
Jul 2017
 - 
Today
Associate Professor, Graduate School of Medical Science, Kanazawa University
 
Apr 2002
 - 
Jun 2017
Assistant Professor, Graduate School of Medical Science, Kanazawa University
 
Jan 2001
 - 
Mar 2002
Science and Technology Research Fellow, : Tokyo Metropolitan Institute for Neuroscience, Japan Science and Technology Agency
 
Oct 1999
 - 
Dec 2000
Research associate (Post-doc), Department of Neurochemistry, Tokyo Metropolitan Institute for Neuroscience
 
Apr 1998
 - 
Sep 1999
Research associate, Bioanalytical Systems, Inc.
 

Education

 
Apr 1994
 - 
Mar 1998
Doctoral program, Division of Materials Science and Biotechnology, Graduate School of Engineering, Tokyo University of Agriculture and Technology
 
Apr 1992
 - 
Mar 1994
Master's program, Division of Materials Science and Biotechnology, Graduate School of Engineering, Tokyo University of Agriculture and Technology
 
Apr 1990
 - 
Mar 1992
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology
 

Awards & Honors

 
2018
Research Grant, SENSIN Medical Research Foundation
 
2014
28th Research Grant, The HOKKOKU Cancer Foundation
 
2014
27th Ono Medical Research Grant, Ono Medical Research Foundation
 
2013
"Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.", 2013 Vascular Cell Biology Travel scholarship, Gordon Research Conference
 
2012
Research Grant, SENSHIN Research Foundation
 
2013
Research Grant, SUZUKEN Memorial Foundation
 
2013
26th NOVARTIS Research Encouragement Award, The NOVARTIS Foundation for the Promotion of Science
 
2013
Research Grant, Astellas Foundation for Research on Metabolic Disorders
 
2013
Naito's Memorial Research Encouragement Award, Naito Foundation
 
2013
Medical Research Encouragement Award, Takeda Science Foundation
 
2013
Research Grant, Japan Foundation for Applied Enzymology
 
2013
53rd Academic Encouragement Award, Ube Industries Foundation
 
2012
Research Grant, Life Science Foundation of Japan
 
2006
Young Investigator Award
 
2004
6th Research Grant, SENSHIN Medical Research Foundation
 
2004
Mitsubishi Pharma Research Foundation
 

Published Papers

 
Yasuda Daisuke, Kobayashi Daiki, Akahoshi Noriyuki, Ohto-Nakanishi Takayo, Yoshioka Kazuaki, Takuwa Yoh, Mizuno Seiya, Takahashi Satoru, Ishii Satoshi
JOURNAL OF CLINICAL INVESTIGATION   129(10) 4332-4349   Oct 2019   [Refereed]
Kitano Teppei, Usui Soichiro, Takashima Shin-ichiro, Inoue Oto, Goten Chiaki, Nomura Ayano, Yoshioka Kazuaki, Okajima Masaki, Kaneko Shuichi, Takuwa Yoh, Takamura Masayuki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   511(1) 179-184   Mar 2019   [Refereed]
Aung Khin Thuzar, Yoshioka Kazuaki, Aki Sho, Ishimaru Kazuhiro, Takuwa Noriko, Takuwa Yoh
JOURNAL OF PHYSIOLOGICAL SCIENCES   69(2) 263-280   Mar 2019   [Refereed]
Sarker Md Azadul Kabir, Aki Sho, Yoshioka Kazuaki, Kuno Kouji, Okamoto Yasuo, Ishimaru Kazuhiro, Takuwa Noriko, Takuwa Yoh
ENDOCRINOLOGY   160(1) 235-248   Jan 2019   [Refereed]
Pham Hoa Q., Yoshioka Kazuaki, Mohri Hiromi, Nakata Hiroki, Aki Sho, Ishimaru Kazuhiro, Takuwa Noriko, Takuwa Yoh
GENES TO CELLS   23(8) 670-687   Aug 2018   [Refereed]
Zhao Juanjuan, Okamoto Yasuo, Asano Yuya, Ishimaru Kazuhiro, Aki Sho, Yoshioka Kazuaki, Takuwa Noriko, Wada Takashi, Inagaki Yutaka, Takahashi Chiaki, Nishiuchi Takumi, Takuwa Yoh
PLOS ONE   13(5) e0197604   May 2018   [Refereed]
Mori Masayuki, Sakata Kenji, Nakanishi Chiaki, Nakahashi Takuya, Kawashiri Masa-aki, Yoshioka Kazuaki, Takuwa Yoh, Okada Hirofumi, Yokawa Jun-ichiro, Shimojima Masaya, Yoshimuta Tsuyoshi, Yoshida Shohei, Yamagishi Masakazu, Hayashi Kenshi
HEART AND VESSELS   32(10) 1244-1252   Oct 2017   [Refereed]
Ohkura Sei-ichiro, Usui Soichiro, Takashima Shin-ichiro, Takuwa Noriko, Yoshioka Kazuaki, Okamoto Yasuo, Inagaki Yutaka, Sugimoto Naotoshi, Kitano Teppei, Takamura Masayuki, Wada Takashi, Kaneko Shuichi, Takuwa Yoh
PLOS ONE   12(8) e0182329   Aug 2017   [Refereed]
Serafimidis Ioannis, Rodriguez-Aznar Eva, Lesche Mathias, Yoshioka Kazuaki, Takuwa Yoh, Dahl Andreas, Pan Duojia, Gavalas Anthony
PLOS BIOLOGY   15(3) e2000949   Mar 2017   [Refereed]
Aki Sho, Yoshioka Kazuaki, Okamoto Yasuo, Takuwa Noriko, Takuwa Yoh
JOURNAL OF BIOLOGICAL CHEMISTRY   290(10) 6086-6105   Mar 2015   [Refereed]

Misc

 
YOSHIOKA Kazuaki
Application Note(Oxford Instruments, Andor)      Aug 2019   [Invited]
S1P(2), A RECEPTOR FOR THE LYSOPHOSPHOLIPID MEDIATOR SPHINGOSINE 1-PHOSPHATE, PROTECTS AGAINST VASCULAR BARRIER DISRUPTION
Okamoto Yasuo, Cui Hong, Yoshioka Kazuaki, Takuwa Noriko, Shibamoto Toshishige, Takuwa Yoh
SHOCK   46(4) 28   Oct 2016   [Refereed]
Saori Koizumi, Kazuaki Yoshioka, Sho Aki, Yoh Takuwa
The Juzen Medical Society Kanazawa University   125(2) 77-78   Jun 2016   [Invited]
Yoshioka, K., Takuwa, N., Okamoto, Y., Takuwa, Y
Seikagaku. The Journal of Japanese Biochemical Society   85(9) 775-780   Sep 2013   [Invited]
Class II PI3 kinase C2 alpha has an essential role in angiogenesis and vascular homeostasis through regulating endosomal trafficking
Yoshioka Kazuaki, Takuwa Noriko, Okamoto Yasuo, Takuwa Yoh
JOURNAL OF PHYSIOLOGICAL SCIENCES   63 S98   2013   [Refereed]
Sphingosine-1-phosphate receptor-2 plays a protective role against anaphylactic shock through inhibiting eNOS
Cui Hong, Okamoto Yasuo, Yoshioka Kazuaki, Du Wa, Takuwa Noriko, Zhang Wei, Biswas Kuntal, Aki Sho, Zhao JuanJuan, Kuda Yuichi, Asano Masahide, Shibamoto Toshishige, Takuwa Yoh
JOURNAL OF PHYSIOLOGICAL SCIENCES   63 S119   2013   [Refereed]
Class II PI3 kinase-C2 alpha plays essential roles in endosomal Rac1 activation and cell migration in S1P-stimulated endothelial cells
Biswas Kuntal, Yoshioka Kazuaki, Aki Sho, Cui Hong, Zhao JuanJuan, Kuda Yuichi, Takuwa Noriko, Okamoto Yasuo, Takuwa Yoh
JOURNAL OF PHYSIOLOGICAL SCIENCES   63 S136   2013   [Refereed]
Disruption of sphingosine-1-phosphate receptor-2 gene inhibits atherosclerosis in apoE-deficient mice
Wang Fei, Okamoto Yasuo, Inoki Isao, Yoshioka Kazuaki, Takuwa Noriko, Takuwa Yoh
JOURNAL OF PHARMACOLOGICAL SCIENCES   115 97P   2011   [Refereed]
Okamoto, Y., Yoshioka, K., Takuwa, N., Takuwa, Y.
Seikagaku   83(6) 536-544   2011   [Invited]

Books etc

 
Bioactive Lipid Mediators. Yokomizo T., Murakami M. (eds)
Takuwa N., Okamoto Y., Yoshioka K., Takuwa Y. (Part:Joint Work, p237-252, Vascular endothelial S1P2 receptor limits tumor angiogenesis and hyperpermeability.)
Springer   2015   ISBN:978-443155669-5;978-443155668-8
Methods in Signal Transduction Series “G Protein-Coupled Receptors: Structure, Function, and Ligand Screening” Editors: Haga, T. and Takeda, S
Nakata H., Yoshioka K., Kamiya T. (Part:Joint Work, p219-240, Oligomerization of G Protein-Coupled Purinergic Receptors.)
CRC Press   Jan 2005   ISBN:978-142003827-9;0849327717;978-084932771-1

Conference Activities & Talks

 
Regulation of intracellular clearance by 3'-phosphoinositide-specific phosphatase, myotubularin-relatedprotein-4 (MTMR4).
Kazuaki Yoshioka, Quynh H. Pham, Sho Aki, Noriko Takuwa1, Yoh Takuwa
第92回日本生化学会大会、横浜パシフィコ(横浜)   18 Sep 2019   The Japanese Biochemical Society
Differential roles of class II PI3K in endocytosis and endosomal signaling
Kazuaki Yoshioka, Khin Thuzar Aung, Md Azadul Kabir Sarker, Sho Aki, Kuntal Biswas, Noriko Takuwa, Yoh Takuwa
60th International Conference on the Bioscience of Lipids, Hitotsubashi Hall (Tokyo)   17 Jun 2019   
Sequential phosphoinositide conversion is required for transforming growth factor β-induced receptor endocytosis and Smad2/3 activation in endothelial cells
Sho Aki, Kazuaki Yoshioka, Noriko Takuwa, Yoh Takuwa
60th International Conference on the Bioscience of Lipids, Hitotsubashi Hall (Tokyo)   17 Jun 2019   
Essential role of class II PI3K in endocytosis and endosomal signaling [Invited]
Yoshioka K., Aung KT., Sarker Md.A.K., Aki S., Biswas K., Takuwa N., Takuwa Y.
9th Federation of the Asia and Oceanian Physiological Societies (FAOPS2019) Symposium: Dynamics of membrane trafficking and intracellular signaling. (Kobe, Japan)   28 Mar 2019   
Sequential phosphoinositide conversion is required for TGFβ-induced receptor endocytosis in ECs.
Sho Aki, Kazuaki Yoshioka, Noriko Takuwa, Yoh Takuwa
the 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019), Kobe, Japan   28 Mar 2019   
S1P2 aggravates lung fibrosis through altering alveolar macrophage. polarization in mice
Yasuo Okamoto, Juanjuan Zhao, Kazuaki Yoshioka, Sho Aki, Kazuhiro Ishimaru, Noriko Takuwa, Yoh Takuwa
the 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019), Kobe, Japan   28 Mar 2019   
Novel indispensable role of and isoforms of class II PI3K for uterine smooth muscle contraction and labor
Azadul Kabir Sarker, Sho Aki, Kazuaki Yoshioka, Koji Kuno, Kazuhiro Ishimaru Noriko Takuwa, Yoh Takuwa
第54回北陸生殖医学会学術講演会   3 Jun 2018   
Class II phosphoinositide 3-kinase isoforms PI3K-C2α and PI3K-C2β play essential roles in pinocytosis in vascular endothelial cells 
Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Yoh Takuwa 
第 95 回日本生理学会大会    28 Mar 2018   
Indispensable role of α and β isoforms of class II phosphoinositide 3-kinases (PI3K) in the uterine smooth muscle contraction during labor 
Yoh Takuwa Juanjuan Zhao, Yasuo, Okamoto, Kazuaki Yoshioka and Noriko Takuwa.
第 95 回日本生理学会大会    28 Mar 2018   
Myotubularin-related protein 4 (MTMR4), a phosphoinositide 3'-phosphatase, regulates endolysosome integrity and autophagy flux in human lung alveolar epithelial A549 cells 
Quynh Hoa Pham, Yoshioka Kazuaki, Azadul Sarker Kabir, Aung Thuzar Khin, Islam Shahidul, Aki Sho, Ishimaru Kazuhiro, Takuwa Noriko, Takuwa Yoh
第 95 回日本生理学会大会    28 Mar 2018   

Research Grants & Projects

 
Japan Society for the Promotion of Science (KAKEN): Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2017 - Mar 2020    Investigator(s): Kazuaki YOSHIOKA
SENSHIN Medical Research Foundation: 2018 Research Grant
Project Year: Apr 2018 - Mar 2019    Investigator(s): Kazuaki YOSHIOKA
Japan Society for the Promotion of Science (KAKEN): Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2014 - Mar 2017    Investigator(s): Kazuaki YOSHIOKA
Ono Medical Research Foundation: 27th Research Grant
Project Year: Apr 2014 - Mar 2016    Investigator(s): Kazuaki Yoshioka
Japan Science and Technology Agency (JST): Adaptable and Seamless Technology Transfer Program through Target-driven R&D (A-STEP)
Project Year: Apr 2014 - Mar 2015    Investigator(s): Kazuaki YOSHIOKA
The HOKKOKU Cancer Foundation: 28th Research Grant
Project Year: Apr 2014 - Mar 2015    Investigator(s): Kauzuaki Yoshioka
Japan Society for the Promotion of Science (KAKEN): Grant-in-Aid for Challenging Exploratory Research
Project Year: Apr 2013 - Mar 2015    Investigator(s): Yoh Takuwa
Project Year: Apr 2013 - Mar 2015    Investigator(s): Kazuaki YOSHIOKA
Japan Society for the Promotion of Science (KAKEN): Grant-in-Aid for Scientific Research (B)
Project Year: Apr 2012 - Mar 2015    Investigator(s): Yoh Takuwa
Project Year: Apr 2013 - Mar 2014    Investigator(s): Kazuaki YOSHIOKA

Social Contribution

 
[Interviewee]  Oxford Instruments (Andor) Inc.  Aug 2019
[Organizing Member]  JICA  1 Apr 2015 - 2 Apr 2019
[Organizing Member]  JICA  2 Apr 2019