2018年4月1日
Increased affinity of endothelial cells to NiTi using ultraviolet irradiation: An in vitro study
Journal of Biomedical Materials Research - Part A
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- 巻
- 106
- 号
- 4
- 開始ページ
- 1034
- 終了ページ
- 1038
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/jbm.a.36304
- 出版者・発行元
- John Wiley and Sons Inc.
Nickel–titanium alloy (NiTi) is one of the most popular materials used endovascularly because of its shape memory and superelasticity. The NiTi device needs to be covered by endothelial cells after being placed in the blood vessel to reduce ischemic complications. The objective of this study was to examine the impact of ultraviolet (UV) irradiation on the biocompatibility of NiTi surfaces with endothelial cells. NiTi sheets were treated with UV irradiation for 48 h and human aorta derived endothelial cells were used in this study. UV irradiation converted the NiTi surface to hydrophilic state and increased albumin adsorption. The number of endothelial cell migration, attachment, proliferation as well as their metabolic activity were significantly increased on UV treated NiTi. This study provides the first evidence of the photoactivation of NiTi surfaces by UV irradiation and demonstrates improved biocompatibility of UV-treated NiTi surfaces with vascular endothelial cells. These results suggest that UV irradiation may promote endothelialization of NiTi devices in blood vessels. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1034–1038, 2018.
- リンク情報
- ID情報
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- DOI : 10.1002/jbm.a.36304
- ISSN : 1552-4965
- ISSN : 1549-3296
- SCOPUS ID : 85042491830