Koubun Yasuda - My portal

Profile Information

Affiliation: Faculty of Medicine, Department of Immunology, Hyogo Medical University

Degree: 医学博士(大阪大学)

J-GLOBAL ID: 200901071651250962
researchmap Member ID: 5000037306

Research Interests

免疫応答

Research Areas

Education

- 2001

Osaka University
- 1997

Faculty of Pharmaceutical Sciences, Tohoku University

Papers

Autophagy Inhibition Increased Sensitivity of Pancreatic Cancer Cells to Carbon Ion Radiotherapy.

Makoto Sudo, Hiroko Tsutsui, Shuhei Hayashi, Koubun Yasuda, Keiko Mitani, Nana Iwami, Makoto Anzai, Toshiro Tsubouchi, Mitsuaki Ishida, Sohei Satoi …

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 57(4) 212-225, Jul 19, 2023
IL-33-induced keratoconjunctivitis is mediated by group 2 innate lymphoid cells in mice.

Yuka Hosotani, Koubun Yasuda, Makoto Nagai, Kiyofumi Yamanishi, Nobuo Kanazawa, Fumi Gomi, Yasutomo Imai

Allergology international : official journal of the Japanese Society of Allergology, 72(2) 324-331, Apr, 2023
Thymic stromal lymphopoietin contributes to protection of mice from Strongyloides venezuelensis infection by CD4+ T cell-dependent and -independent pathways.

Atsuhide Koida, Koubun Yasuda, Takumi Adachi, Kazufumi Matsushita, Makoto Yasuda, Shigeru Hirano, Etsushi Kuroda

Biochemical and biophysical research communications, 555 168-174, May 28, 2021
Lung fibroblasts produce IL-33 in response to stimulation with retinoblastoma-binding protein 9 via production of prostaglandin E2.

Takumi Adachi, Koubun Yasuda, Taichiro Muto, Satoshi Serada, Tomohiro Yoshimoto, Ken J Ishii, Etsushi Kuroda, Kimi Araki, Masaki Ohmuraya, Tetsuji Naka …

International immunology, 32(10) 637-652, Sep 30, 2020
Regnase-1 degradation is crucial for IL-33- and IL-25-mediated ILC2 activation.

Kazufumi Matsushita, Hiroki Tanaka, Koubun Yasuda, Takumi Adachi, Ayumi Fukuoka, Shoko Akasaki, Atsuhide Koida, Etsushi Kuroda, Shizuo Akira, Tomohiro Yoshimoto

JCI insight, 5(4), Feb 27, 2020
Periostin forms a functional complex with IgA in human serum.

Junya Ono, Masayuki Takai, Ayami Kamei, Satoshi Nunomura, Yasuhiro Nanri, Tomohito Yoshihara, Shoichiro Ohta, Koubun Yasuda, Simon J Conway, Yasuyuki Yokosaki …

Allergology international : official journal of the Japanese Society of Allergology, 69(1) 111-120, Jan, 2020 Peer-reviewed
Role of eosinophils in protective immunity against secondary nematode infections.

Koubun Yasuda, Etsushi Kuroda

Immunological medicine, 42(4) 148-155, Dec, 2019
Anti-interleukin-6 receptor antibody treatment ameliorates postoperative adhesion formation.

Naoki Uyama, Hiroko Tsutsui, Songtao Wu, Koubun Yasuda, Etsuro Hatano, Xian-Yang Qin, Soichi Kojima, Jiro Fujimoto

Scientific reports, 9(1) 17558-17558, Nov 26, 2019
IL-33-Induced Atopic Dermatitis-Like Inflammation in Mice Is Mediated by Group 2 Innate Lymphoid Cells in Concert with Basophils.

Yasutomo Imai, Koubun Yasuda, Makoto Nagai, Minori Kusakabe, Masato Kubo, Kenji Nakanishi, Kiyofumi Yamanishi

The Journal of investigative dermatology, 139(10) 2185-2194, Oct, 2019 Peer-reviewed
Interleukin-1/-33 Signaling Pathways as Therapeutic Targets for Endometriosis

Toru Kato, Koubun Yasuda, Kazufumi Matsushita, Ken J Ishii, Seiichi Hirota, Tomohiro Yoshimoto, Hiroaki Shibahara

Frontiers in Immunology, 10 2021-2021, Aug, 2019 Peer-reviewed
Interleukin-18 in Health and Disease

International Journal of Molecular Sciences, Feb, 2019 Peer-reviewed
B cells with aberrant activation of Notch1 signaling promote Treg and Th2 cell-dominant T-cell responses via IL-33.

Hiroshi Arima, Momoko Nishikori, Yasuyuki Otsuka, Wataru Kishimoto, Kiyotaka Izumi, Koubun Yasuda, Tomohiro Yoshimoto, Akifumi Takaori-Kondo

Blood advances, 2(18) 2282-2295, Sep 25, 2018 Peer-reviewed
Human cystatin SN is an endogenous protease inhibitor that prevents allergic rhinitis.

Fukuoka A, Matsushita K, Morikawa T, Adachi T, Yasuda K, Kiyonari H, Fujieda S, Yoshimoto T

The Journal of allergy and clinical immunology, Aug, 2018 Peer-reviewed
Host responses to intestinal nematodes.

Yasuda K, Nakanishi K

International immunology, 30(3) 93-102, Mar, 2018 Peer-reviewed
Nematode-Infected Mice Acquire Resistance to Subsequent Infection With Unrelated Nematode by Inducing Highly Responsive Group 2 Innate Lymphoid Cells in the Lung.

Yasuda K, Adachi T, Koida A, Nakanishi K

Frontiers in immunology, 9(SEP) 2132, 2018 Peer-reviewed
Ablation of IL-33 gene exacerbate myocardial remodeling in mice with heart failure induced by mechanical stress

Punniyakoti T. Veeraveedu, Shoji Sanada, Keiji Okuda, Hai Ying Fu, Takashr Matsuzaki, Ryo Araki, Masaki Yamato, Koubun Yasuda, Yasushi Sakata, Tomohiro Yoshimoto …

BIOCHEMICAL PHARMACOLOGY, 138 73-80, Aug, 2017 Peer-reviewed
Expression of IL-33 in ocular surface epithelium induces atopic keratoconjunctivitis with activation of group 2 innate lymphoid cells in mice

Yasutomo Imai, Yuka Hosotani, Hiroto Ishikawa, Koubun Yasuda, Makoto Nagai, Orie Jitsukawa, Fumi Gomi, Kenji Nakanishi, Tomohiro Yoshimoto, Takahiro Nakamura …

SCIENTIFIC REPORTS, 7(1) 10053, Aug, 2017 Peer-reviewed
Activation of group 2 innate lymphoid cells exacerbates and confers corticosteroid resistance to mouse nasal type 2 inflammation

Taiyo Morikawa, Ayumi Fukuoka, Kazufumi Matsushita, Koubun Yasuda, Naruhito Iwasaki, Shoko Akasaki, Shigeharu Fujieda, Tomohiro Yoshimoto

INTERNATIONAL IMMUNOLOGY, 29(5) 221-233, May, 2017 Peer-reviewed
Allergen endotoxins induce T-cell-dependent and non-IgE-mediated nasal hypersensitivity in mice

Naruhito Iwasaki, Kazufumi Matsushita, Ayumi Fukuoka, Masakiyo Nakahira, Makoto Matsumoto, Shoko Akasaki, Koubun Yasuda, Takeshi Shimizu, Tomohiro Yoshimoto

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139(1) 258-+, Jan, 2017 Peer-reviewed
Murine allergic rhinitis and nasal T-h2 activation are mediated via TSLP- and IL-33-signaling pathways

Shoko Akasaki, Kazufumi Matsushita, Yukinori Kato, Ayumi Fukuoka, Naruhito Iwasaki, Masakiyo Nakahira, Shigeharu Fujieda, Koubun Yasuda, Tomohiro Yoshimoto

INTERNATIONAL IMMUNOLOGY, 28(2) 65-76, Feb, 2016 Peer-reviewed

Misc.

カスパーゼ1/11が、IL-33の分泌を制御してIL-33誘導性アトピー性皮膚炎の増悪に関与するかもしれない

草壁みのり, 今井康友, 安田好文, 永井諒, 山西清文

日本皮膚免疫アレルギー学会雑誌, 2(1) 199-199, Oct, 2018
タクロリムスは2型自然リンパ球が産生するTh2サイトカインの産生を抑制する

細谷友雅, 今井康友, 石川裕人, 安田好文, 永井諒, 實川織江, 中西憲司, 善本知広, 山西清文, 五味文

日本眼科学会雑誌, 122(臨増) 254-254, Mar, 2018
A unique DAMP with IL-33-inducing activity increases IL-33-expressing alveolar epithelial type II cells in lungs and induces primary cultured fibroblasts to produce IL-33 in vitro

Takumi Adachi, Koubun Yasuda, Taichiro Muto, Satoshi Serada, Tomohiro Yoshimoto, Tetsuji Naka, Kenji Nakanishi

CYTOKINE, 100 35-35, Dec, 2017
角粘膜上皮の過剰なIL-33はアトピー性角結膜炎を誘導する

今井康友, 細谷友雅, 石川裕人, 安田好文, 永井諒, 實川織江, 五味文, 中西憲司, 善本知広, 中村隆宏 …

アレルギー, 66(4-5) 686-686, May, 2017
アトピー性角結膜炎モデルとしてのIL-33過剰産生遺伝子改変マウスの有用性

細谷友雅, 今井康友, 石川裕人, 中村隆宏, 安田好文, 永井諒, 實川織江, 中西憲司, 善本知広, 山西清文 …

日本眼科学会雑誌, 121(臨増) 173-173, Mar, 2017
IL-33を表皮で過剰に発現するマウスのアトピー性皮膚炎の発症には好塩基球も関与している

今井康友, 安田好文, 山本雅章, 羽田孝司, 永井諒, 善本知広, 山西清文

Journal of Environmental Dermatology and Cutaneous Allergology, 10(4) 481-481, Oct, 2016
Basophils against intestinal parasite infection

60(8) 848-855, Aug, 2016
Skin-specific expression of IL-33 causes atopic dermatitis-like inflammation with activation of group 2 innate lymphoid cells in mice

Y. Imai, K. Yasuda, H. Mizutani, T. Yoshimoto, K. Nakanishi, K. Yamanishi

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 134 S108-S108, May, 2014
Esophageal Epithelial-Derived IL-33 Acts As an Exaggerator of Inflammation in the Pathogenesis of GERD

Tadayuki Oshima, Jing Shan, Taichiro Muto, Koubun Yasuda, Hirokazu Fukui, Jiro Watari, Kenji Nakanishi, Hiroto Miwa

GASTROENTEROLOGY, 146(5) S863-S863, May, 2014
IL-33 KO mice exhibit the reduced immediate type contact hypersensitivity

Y. Imai, T. Haneda, K. Yasuda, T. Yoshimoto, K. Nakanishi, K. Yamanishi

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133 S195-S195, May, 2013
Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice (vol 58, pg 28, 2010)

Masahito Tarutani, Yasutomo Imai, Koubun Yasuda, Hiroko Tsutsui, Kenji Nakanishi, Kiyofumi Yamanishi

JOURNAL OF DERMATOLOGICAL SCIENCE, 59(1) 63-63, Jul, 2010
表皮ランゲルハンス細胞はペプチド抗原によるナイーブT細胞の活性化を細胞間相互作用によって抑制する

今井康友, 林伸樹, 安田好文, 筒井ひろ子, 水谷仁, 中西憲司

Inflammation and Regeneration, 28(4) 333-333, Jul, 2008
「免疫難病・感染症等の先進医療技術」「IL‐18を標的とした自然型アトピー症の治療戦略」新規DC免疫法:抗原とアジュバントでパルスした樹状細胞はナイーブマウスに迅速かつ顕著なTh2応答を誘導する

今井康友, 今井康友, 安田好文, 今村美智子, 林伸樹, 善本知広, 山西清文, 筒井ひろ子, 水谷仁, 中西憲司

免疫難病・感染症等の先進医療技術第5回(最終)公開シンポジウム要旨集平成20年, 42, 2008
Contribution of TRIF to secretion of mature IL-1 beta and IL-18 via the TLR-mediated caspase-1 activation during extracellular bacterial infection in mice

Michiko Imamura, Koubun Yasuda, Jiro Fujimoto, Shizuo Akira, Hiroko Tsutsui, Kenji Nakanishi

HEPATOLOGY, 46(4) 692A-692A, Oct, 2007
376 マウスに移入された抗原とAlumでパルスされたDCはTh2細胞をCaspase-1非依存性に誘導する(抗原提示細胞1,一般演題(デジタルポスター),第57回日本アレルギー学会秋季学術大会)

今井康友, 安田好文, 林伸樹, 松本真琴, 善本知広, 水谷仁, 中西憲司

アレルギー, 56(8), Sep 30, 2007
ナイーブマウスに移入された抗原とAlumでパルスされたDCはTh2細胞をCaspase-1非依存性に誘導する

今井康友, 安田好文, 林伸樹, 松本真琴, 善本知広, 水谷仁, 中西憲司

日本臨床免疫学会会誌, 30(4) 280-280, Aug, 2007
Signal transduction of a T cell receptor in membrane lipid microdomains.

野田敏司, 斉藤伸一郎, 安田好文, 林文枝, 小杉厚

臨床免疫, 31(2) 190-196, Feb, 1999
A role of DIG fraction in TCR signal transduction: Localization of phosphorylated CD3-zeta and activated lck in DIG on T cell activation

A Kosugi, SI Saitoh, S Noda, K Yasuda, F Hayashi, T Hamaoka

MOLECULAR BIOLOGY OF THE CELL, 9 97A-97A, Nov, 1998
TCRシグナル伝達における可溶化剤不溶性細胞膜DIG画分の役割(1) T細胞活性化に伴うリン酸化CD3ζと活性型Lck分子の局在

安田好文, 小杉厚, 斉藤伸一郎, 野田敏司, 濱岡利之

日本臨床免疫学会会誌, (26回抄録集) 193-193, Oct, 1998
TCRシグナル伝達における可溶化剤不溶性細胞膜DIG画分の役割(2) 変異型Lck分子を用いた解析

林文枝, 安田好文, 斉藤伸一郎, 野田敏司, 濱岡利之, 小杉厚

日本臨床免疫学会会誌, (26回抄録集) 193-193, Oct, 1998

Professional Memberships

Research Projects

IL-33の働き