2009年
Effects of Relaxin on Development of Mesangial Proliferative Nephritis
Annals of the New York Academy of Sciences
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- 巻
- 1160
- 号
- 開始ページ
- 300
- 終了ページ
- 303
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.1749-6632.2009.03831.x
- 出版者・発行元
- BLACKWELL PUBLISHING
The involvement of relaxin (RLX) in nephritis has not been fully elucidated. In this study, we examined the expression of the R.LX receptor and effects of RLX administration in antithymocyte serum (ATS) nephritis. The nephritic glomeruli showed an increased immunostaining for LGR7 compared to normal glomeruli. The administration of RLX for 7 days to rats with ATS nephritis did not cause an alteration in blood pressure or body weight. On the sixth day, however, a significant reduction in urinary protein was recognized in rats treated with RLX. Histological studies revealed the amelioration of glomerular accumulation of Periodic acid-Schiff stain-positive matrix in rats treated with R.LX. Significant reductions of phosphorylated SMAD2, mesangial cell proliferation, and alpha-smooth muscle actin expression were observed in rats treated with RLX. These results suggest that RLX is a promising therapeutic tool for nephritic diseases.
- リンク情報
- ID情報
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- DOI : 10.1111/j.1749-6632.2009.03831.x
- ISSN : 0077-8923
- Web of Science ID : WOS:000265652100059