論文

査読有り
2007年2月

Downregulated P1 promoter-driven hepatocyte nuclear factor-4 alpha expression in human colorectal carcinoma is a new prognostic factor against liver metastasis

PATHOLOGY INTERNATIONAL
  • Tomoko Oshima
  • Takashi Kawasaki
  • Riuko Ohashi
  • Go Hasegawa
  • Shuying Jiang
  • Hajime Umezu
  • Yutaka Aoyagi
  • Hiroko Iwanari
  • Toshiya Tanaka
  • Takao Hamakubo
  • Tatsuhiko Kodama
  • Makoto Naito
  • 全て表示

57
2
開始ページ
82
終了ページ
90
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/j.1440-1827.2006.02061.x
出版者・発行元
BLACKWELL PUBLISHING

Liver metastases are the most critical prognostic factors for patients with colorectal carcinomas (CRC). It has been reported that the dysregulation of hepatocyte nuclear factor-4 alpha (HNF4 alpha) expression is linked to the development of CRC, gastric cancer and hepatocellular carcinoma. The purpose of the present paper was to examine the P1 and P2 promoter-driven HNF4 alpha (P1 and P2) expression in surgically resected CRC. Immunohistochemically, P1, P2, MUC1 and CD10 expression were evaluated in 63 cases of primary CRC. Positive staining with P1, P2, MUC1 and CD10 antibodies were observed in 37 (59%), 63 (100%), 42 (67%) and 27 (43%) cases, respectively. Loss or decreased P1 expression was observed with respect to the depth of the tumor invasion. The frequency of P1-positive expression in Dukes' C and D tumors was significantly lower than that in Dukes' A and B tumors. There was a relationship between the loss of P1 expression and metachronous liver metastases, and the survival rate of the P1-negative patients without liver metastasis at the time of the primary CRC resection tended to be worse than that of the P1-positive patients. These findings suggest that downregulation of P1 expression is involved in tumor metastasis and a worse prognosis.

リンク情報
DOI
https://doi.org/10.1111/j.1440-1827.2006.02061.x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17300672
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000243941600005&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/j.1440-1827.2006.02061.x
  • ISSN : 1320-5463
  • PubMed ID : 17300672
  • Web of Science ID : WOS:000243941600005

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