2016年6月
Dynamic Kinetic Resolution Approach for the Asymmetric Synthesis of Tetrahydrobenzodiazepines Using Transfer Hydrogenation by Chiral Phosphoric Acid
CHEMISTRY-A EUROPEAN JOURNAL
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- 巻
- 22
- 号
- 24
- 開始ページ
- 8078
- 終了ページ
- 8083
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/chem.201601611
- 出版者・発行元
- WILEY-V C H VERLAG GMBH
Asymmetric synthesis of tetrahydrobenzodiazepines was achieved by transfer hydrogenation of dihydrobenzodiazepines with benzothiazoline having a hydrogenbonding donor substituent by means of a newly synthesized chiral phosphoric acid. This method was applicable to various racemic dihydrobenzodiazepines to give the corresponding products in good yields with excellent diastereoselectivities and enantioselectivities taking advantage of the dynamic kinetic resolution. Furthermore, the effect of bulky substituent at 3,3'-position on the catalyst and hydrogen-bonding donor substituent on benzothiazoline was fully elucidated by the theoretical study.
- リンク情報
- ID情報
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- DOI : 10.1002/chem.201601611
- ISSN : 0947-6539
- eISSN : 1521-3765
- Web of Science ID : WOS:000380269400012