Papers

Peer-reviewed Invited
Jul, 2017

Multinuclear zinc bisamidinate catalyzed asymmetric alkylation of alpha-ketoesters and its unique chemoselectivity

CHEMICAL COMMUNICATIONS
  • Masahiro Yamanaka
    • ,
  • Masamitsu Inaba
    • ,
  • Ryo Gotoh
    • ,
  • Yoshiyuki Ueki
    • ,
  • Kenichiro Matsui
Volume
53
Number
54
First page
7513
Last page
7516
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1039/c7cc01736g
Publisher
ROYAL SOC CHEMISTRY
The multinuclear Zn-bisamidinate catalyzed enantioselective addition of Et2Zn to alpha-ketoesters has been developed. The steric tuning of two amidinate units as well as multiple coordination on the Zn atoms play a key role in achieving high enantioselectivity (up to 98% ee) and unique chemoselectivity. The present catalyst exhibited the preferential alkylation of alpha-ketoesters even in the presence of aldehydes.
Link information
DOI
https://doi.org/10.1039/c7cc01736g
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000404606800019&DestApp=WOS_CPL
ID information
  • DOI : 10.1039/c7cc01736g
  • ISSN : 1359-7345
  • eISSN : 1364-548X
  • Web of Science ID : WOS:000404606800019
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