論文

査読有り
1999年10月

Interaction between collagens and glycosaminoglycans investigated using a surface plasmon resonance biosensor

GLYCOBIOLOGY
  • H Munakata
  • ,
  • K Takagaki
  • ,
  • M Majima
  • ,
  • M Endo

9
10
開始ページ
1023
終了ページ
1027
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/glycob/9.10.1023
出版者・発行元
OXFORD UNIV PRESS

The interactions of glycosaminoglycans with collagens and other glycoproteins in extracellular matrix play important roles in cell adhesion and extracellular matrix assembly. In order to clarify the chemical bases for these interactions, glycosaminoglycan solutions were injected onto sensor surfaces on which collagens, fibronectin, laminin, and vitronectin were immobilized. Heparin bound to type V collagen, type IX collagen, fibronectin, laminin, and vitronectin; and chondroitin sulfate E bound to type II, type V, and type Vn collagen. Heparin showed a higher affinity for type IX collagen than for type V collagen. On the other hand, chondroitin sulfate E showed the highest affinity for type V collagen. The binding of chondroitin sulfate E to type V collagen showed higher affinity than that of heparin to type V collagen. These data suggest that a novel characteristic sequence included in chondroitin sulfate E is involved in binding to type V collagen.

Web of Science ® 被引用回数 : 44

リンク情報
DOI
https://doi.org/10.1093/glycob/9.10.1023
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/10521538
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000082810000008&DestApp=WOS_CPL

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