Sotomaru Yusuke

J-GLOBAL         Last updated: Dec 13, 2018 at 03:44
Sotomaru Yusuke
Hiroshima University
Job title
Doctor of Philosophy(Tokyo University of Agriculture), Master(Tokyo University of Agriculture)
Research funding number


Studies on reproductive developmental engineering technologies in mammals, especially in experimental and domestic animals: Development of animal cloning system using a micromanipulation and nuclear transfer techniques, and investigation of developmental mechanism in the early stage embryos

Research Areas


Academic & Professional Experience

Apr 1998
Mar 1999
Research Associate, Kinki University
Apr 2001
Mar 2004
Researcher, Central Institute for Experimental Animals
Apr 2004
Feb 2005
Office Director, Central Institute for Experimental Animals
Feb 2005
Mar 2007
Associate Professor, Natural Science Center for Basic Research and Development, Hiroshima University
Apr 2007
Mar 2011
Associate Professor, Natural Science Center for Basic Research and Development, Hiroshima University


Apr 1996
Mar 1998
Graduate School, Division of Agricultural Science, Kinki University
Apr 1991
Mar 1993
Animal Science, Graduate School, Division of Agriculture, Tokyo University of Agriculture
Apr 1987
Mar 1991
Faculty of Agriculture, Tokyo University of Agriculture

Published Papers

Sakashita A, Wakai T, Kawabata Y, Nishimura C, Sotomaru Y, Alavattam KG, Namekawa SH, Kono T.
Biol Reprod.      Oct 2018   [Refereed]
The fertility of sex-reversed XY female mice is severely impaired by a massive loss of oocytes and failure of meiotic progression. This phenomenon remains an outstanding mystery. We sought to determine the molecular etiology of XY oocyte dysfuncti...
Shirafuji, Toshihiko; Ueyama, Takehiko; Adachi, Naoko; Yoshino, Ken-Ichi; Sotomaru, Yusuke; Uwada, Junsuke; Kaneoka, Azumi; Ueda, Taro; Tanaka, Shigeru; Hide, Izumi; Saito, Naoaki; Sakai, Norio
JOURNAL OF NEUROSCIENCE   38(2) 278-290   Jan 2018   [Refereed]
Protein kinase C gamma (PKC gamma) knock-out (KO) animals exhibit symptoms of Parkinson's disease (PD), including dopaminergic neuronal loss in the substantia nigra. However, the PKC gamma substrates responsible for the survival of dopaminergic ne...
Kanda, Akifumi; Nobukiyo, Asako; Yoshioka, Miyuki; Hatakeyama, Teruhiko; Sotomaru, Yusuke
THERIOGENOLOGY   106 221-226   Jan 2018   [Refereed]
The common marmoset (Callithrix jacchus) is an experimental animal that is considered suitable for the creation of next-generation human disease models. It has recently been used in the reproductive technology field. Oocytes can be effectively col...
Yang, Bo; Kumoto, Takahiro; Arima, Takeshi; Nakamura, Minako; Sanada, Yohei; Kumrungsee, Thanutchaporn; Sotomaru, Yusuke; Shimada, Masayuki; Yanaka, Noriyuki
GENES TO CELLS   23(3) 136-145   Mar 2018   [Refereed]
To determine adipocytokines that play a regulatory role during obesity development, we explored the genes that encode growth factors and investigated the physiological functions for adipose tissue development. Here, we isolated amphiregulin (Areg)...
Kumamoto, Soichiro; Takahashi, Nozomi; Nomura, Kayo; Fujiwara, Makoto; Kijioka, Megumi; Uno, Yoshinobu; Matsuda, Yoichi; Sotomaru, Yusuke; Kono, Tomohiro
HUMAN MOLECULAR GENETICS   26(19) 3653-3662   Oct 2017   [Refereed]
The Dlk1-Dio3 imprinted domain functions in embryonic development but the roles of noncoding RNAs expressed from this domain remain unclear. We addressed this question by generating transgenic (TG) mice harbouring a BAC carrying IG-DMR (intergenic...

Conference Activities & Talks

A mutation of the spinocerebellar ataxia gene CACNA1G induces cerebellar Purkinje cell death and ataxia in mice.
Y. Matsuda
SFN2017   11 Nov 2017   
Techniques for creating genetically identical animalsin the non-human primates. [Invited]
Yusuke Sotomaru
2017 Asia-Oceania Regional Meeting for Marmoset Research   16 Mar 2017   
Characterization of common marmoset (Callithrix jacchus) bone marrow-derived cells.
Akifumi Kanda
International Society for Stem Cell Research   14 Jun 2012   International Society for Stem Cell Research
Effect of Donor-cell type on developmental potential of clone embryos in the common marmosets
Sotomaru Y
Marmoset –Frontiers in Biomedical Researches on Marmosets as a Primate Model   21 Feb 2012   
Use of an adhesion barrier for preventing postoperative adhesion in common marmosets that underwent oocyte collection
Hatakayama T
Marmoset –Frontiers in Biomedical Researches on Marmosets as a Primate Model   21 Feb 2012   Japan Society for Marmoset Reseach

Association Memberships


Research Grants & Projects

Hospital, National Center for Geriatrics and Gerontology: Strategic Research Programs for Brain Science(ACT-C)
Project Year: Apr 2017 - Mar 2018
Japan Agency for Medical Research and Development: Strategic Research Program for Brain Sciences
Project Year: Apr 2016 - Mar 2017
Japan Agency for Medical Research and Development: Strategic Research Program for Brain Sciences
Project Year: Apr 2015 - Mar 2016
Project Year: 2015 - 2018
Project Year: 2015 - 2018