2018年3月
Transgenic mice specifically expressing amphiregulin in white adipose tissue showed less adipose tissue mass.
Genes to cells : devoted to molecular & cellular mechanisms
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- 巻
- 23
- 号
- 3
- 開始ページ
- 136
- 終了ページ
- 145
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/gtc.12558
- 出版者・発行元
- WILEY
To determine adipocytokines that play a regulatory role during obesity development, we explored the genes that encode growth factors and investigated the physiological functions for adipose tissue development. Here, we isolated amphiregulin (Areg) gene whose expression was significantly up-regulated in obese adipose tissues. Areg mRNA level was positively correlated with macrophage marker gene expression in adipose tissues in vivo. Unexpectedly, Areg transgenic mice showed less adipose tissue mass with increased mRNA expression levels of Tnf-α and peroxisome proliferator-activated receptor γ coactivator 1α (Pgc-1α) and delayed white adipose tissue development during the convalescent stage in a dextran sodium sulfate-induced colitis model. This study showed that Areg mRNA expression was significantly up-regulated in obese adipose tissues and over-expression of Areg in white adipose tissue caused less adipose tissue mass.
- ID情報
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- DOI : 10.1111/gtc.12558
- ISSN : 1356-9597
- PubMed ID : 29341420