Yusuke Sotomaru - My portal

Profile Information

Affiliation: 教授, ., Hiroshima University

Degree: Doctor of Philosophy(Tokyo University of Agriculture)
Master(Tokyo University of Agriculture)

Researcher number: 90309352
J-GLOBAL ID: 200901082522797078
researchmap Member ID: 5000040885

Studies on reproductive developmental engineering technologies in mammals, especially in experimental and domestic animals: Development of animal cloning system using a micromanipulation and nuclear transfer techniques, and investigation of developmental mechanism in the early stage embryos

Research Interests

Research Areas

Life sciences / Laboratory animal science /

Research History

Apr, 2013

Vice Director, Natural Science Center for Basic Research and Development, Hiroshima University
Apr, 2011

Professor, Natural Science Center for Basic Research and Development, Hiroshima University
Apr, 2007 - Mar, 2011

Associate Professor, Natural Science Center for Basic Research and Development, Hiroshima University
Feb, 2005 - Mar, 2007

Associate Professor, Natural Science Center for Basic Research and Development, Hiroshima University
Apr, 2004 - Feb, 2005

Office Director, Central Institute for Experimental Animals
Apr, 2001 - Mar, 2004

Researcher, Central Institute for Experimental Animals
Apr, 1998 - Mar, 1999

Research Associate, Kinki University

Education

Apr, 1996 - Mar, 1998

Graduate School, Division of Agricultural Science, Graduate School, Division of Agricultural Science, Kinki University
Apr, 1991 - Mar, 1993

Animal Science, Graduate School, Division of Agriculture, Tokyo University of Agriculture
Apr, 1987 - Mar, 1991

Faculty of Agriculture, Tokyo University of Agriculture
Apr, 1987 - Mar, 1991

Faculty of Agriculture, Tokyo University of Agriculture

Papers

miR-582-5p targets Skp1 and regulates NF-Kappa B signaling-mediated inflammation

Li, Rongzhi, Sano, Tomomi, Mizokami, Akiko, Fukuda, Takao, Shinjo, Takanori, Iwashita, Misaki, Yamashita, Akiko, Sanui, Terukazu, Nakatsu, Yusuke, Sotomaru, Yusuke …

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 734, Jan 15, 2023 Peer-reviewed
In Vitro Transfection of Up-Regulated Genes Identified in Favorable-Outcome Neuroblastoma into Cell Lines

Hiyama, Yoko, Yamaoka, Emi, Fukazawa, Takahiro, Kojima, Masato, Sotomaru, Yusuke, Hiyama, Eiso

CELLS, 11(19), Oct, 2022 Peer-reviewed
GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after optic nerve crush in mice

Masuda, Shun, Tanaka, Shigeru, Shiraki, Hiroko, Sotomaru, Yusuke, Harada, Kana, Hide, Izumi, Kiuchi, Yoshiaki, Sakai, Norio

NEUROBIOLOGY OF DISEASE, 172, Oct 1, 2022 Peer-reviewed
Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation

Yoshimoto, Yuki, Uezumi, Akiyoshi, Ikemoto-Uezumi, Madoka, Tanaka, Kaori, Yu, Xinyi, Kurosawa, Tamaki, Yambe, Shinsei, Maehara, Kazumitsu, Ohkawa, Yasuyuki, Sotomaru, Yusuke …

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 10, Mar 9, 2022 Peer-reviewed
Disruption of piRNA machinery by deletion of ASZ1/GASZ results in the expression of aberrant chimeric transcripts in gonocytes

Ikeda, Shinya, Tanaka, Koki, Ohtani, Reiko, Kanda, Akifumi, Sotomaru, Yusuke, Kono, Tomohiro, Obata, Yayoi

JOURNAL OF REPRODUCTION AND DEVELOPMENT, 68(2) 125-136, 2022 Peer-reviewed
Overexpression of miR-125b in Osteoblasts Improves Age-Related Changes in Bone Mass and Quality through Suppression of Osteoclast Formation

Ito, Shota, Minamizaki, Tomoko, Kohno, Shohei, Sotomaru, Yusuke, Kitaura, Yoshiaki, Ohba, Shinsuke, Sugiyama, Toshie, Aubin, Jane E., Tanimoto, Kotaro, Yoshiko, Yuji

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(13), Jul, 2021 Peer-reviewed
Establishment of an integrated automated embryonic manipulation system for producing genetically modified mice

Eto, Tomoo, Ueda, Hiroki, Ito, Ryoji, Takahashi, Tsukasa, Watanabe, Toshiaki, Goto, Motohito, Sotomaru, Yusuke, Tanaka, Nobuaki, Takahashi, Riichi

SCIENTIFIC REPORTS, 11(1), Jun 3, 2021 Peer-reviewed
Single-Cell RNA-Sequencing Reveals the Breadth of Osteoblast Heterogeneity

Yoshioka, Hirotaka, Okita, Saki, Nakano, Masashi, Minamizaki, Tomoko, Nubukiyo, Asako, Sotomaru, Yusuke, Bonnelye, Edith, Kozai, Katsuyuki, Tanimoto, Kotaro, Aubin, Jane E. …

JBMR PLUS, 5(6), Jun, 2021 Peer-reviewed
UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes

Sera, Yasuyuki, Nakata, Yuichiro, Ueda, Takeshi, Yamasaki, Norimasa, Koide, Shuhei, Kobayashi, Hiroshi, Ikeda, Ken-ichiro, Kobatake, Kohei, Iwasaki, Masayuki, Oda, Hideaki …

BLOOD, 137(7) 908-922, Feb 18, 2021 Peer-reviewed
Optineurin defects cause TDP43-pathology with autophagic vacuolar formation

Kurashige, Takashi, Kuramochi, Masahito, Ohsawa, Ryosuke, Yamashita, Yui, Shioi, Go, Morino, Hiroyuki, Kamada, Masaki, Ayaki, Takashi, Ito, Hidefumi, Sotomaru, Yusuke …

NEUROBIOLOGY OF DISEASE, 148, Jan, 2021 Peer-reviewed
Effect of Cetrorelix administration on ovarian stimulation in aged mice

Kanda, Akifumi, Nobukiyo, Asako, Sotomaru, Yusuke

EXPERIMENTAL ANIMALS, 70(1) 31-36, 2021 Peer-reviewed
Oncogenic mutation in RAS-RAF axis leads to increased expression ofGREB1, resulting in tumor proliferation in colorectal cancer

Kochi, Masatoshi, Hinoi, Takao, Niitsu, Hiroaki, Miguchi, Masashi, Saito, Yasufumi, Sada, Haruki, Sentani, Kazuhiro, Sakamoto, Naoya, Oue, Naohide, Tashiro, Hirotaka …

CANCER SCIENCE, 111(10) 3540-3549, Oct, 2020 Peer-reviewed
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells

Naka, Kazuhito, Ochiai, Ryosuke, Matsubara, Eriko, Kondo, Chie, Yang, Kyung-Min, Hoshii, Takayuki, Araki, Masatake, Araki, Kimi, Sotomaru, Yusuke, Sasaki, Ko …

NATURE COMMUNICATIONS, 11(1), Sep 17, 2020 Peer-reviewed
Anti-inflammatory effects of miRNA-146a induced in adipose and periodontal tissues

Sanada, Taiki, Sano, Tomomi, Sotomaru, Yusuke, Alshargabi, Rehab, Yamawaki, Yosuke, Yamashita, Akiko, Matsunaga, Hiroaki, Iwashita, Misaki, Shinjo, Takanori, Kanematsu, Takashi …

BIOCHEMISTRY AND BIOPHYSICS REPORTS, 22, Jul, 2020 Peer-reviewed
Optineurin regulates osteoblastogenesis through STAT1

Mizuno, Noriyoshi, Iwata, Tomoyuki, Ohsawa, Ryosuke, Ouhara, Kazuhisa, Matsuda, Shinji, Kajiya, Mikihito, Matsuda, Yukiko, Kume, Kodai, Tada, Yui, Morino, Hiroyuki …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 525(4) 889-894, May 14, 2020 Peer-reviewed
Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction

Kobatake, Kohei, Ikeda, Ken-ichiro, Nakata, Yuichiro, Yamasaki, Norimasa, Ueda, Takeshi, Kanai, Akinori, Sentani, Kazuhiro, Sera, Yasuyuki, Hayashi, Tetsutaro, Koizumi, Miho …

CLINICAL CANCER RESEARCH, 26(8) 2065-2079, Apr, 2020 Peer-reviewed
The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice

Minamizaki, Tomoko, Nakao, Yuko, Irie, Yasumasa, Ahmed, Faisal, Itoh, Shota, Sarmin, Nushrat, Yoshioka, Hirotaka, Nobukiyo, Asako, Fujimoto, Chise, Niida, Shumpei …

COMMUNICATIONS BIOLOGY, 3(1) 30-30, Jan 16, 2020 Peer-reviewed
The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment

Kumrungsee, Thanutchaporn, Kariya, Taishi, Hashimoto, Kotaro, Koyano, Takayuki, Yazawa, Nao, Hashimoto, Takao, Sanada, Yohei, Matsuyama, Makoto, Sotomaru, Yusuke, Sakurai, Hiroaki …

SCIENTIFIC REPORTS, 9, Oct 1, 2019 Peer-reviewed
Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure

Sano, Tomomi, Sanada, Taiki, Sotomaru, Yusuke, Shinjo, Takanori, Iwashita, Misaki, Yamashita, Akiko, Fukuda, Takao, Sanui, Terukazu, Asano, Tomoichiro, Kanematsu, Takashi …

NUTRITION & METABOLISM, 16(1), Jul 4, 2019 Peer-reviewed
Synbiotics suppress colitis-induced tumorigenesis in a colon-specific cancer mouse model

Saito, Yasufumi, Hinoi, Takao, Adachi, Tomohiro, Miguchi, Masashi, Niitsu, Hiroaki, Kochi, Masatoshi, Sada, Haruki, Sotomaru, Yusuke, Sakamoto, Naoya, Sentani, Kazuhiro …

PLOS ONE, 14(6), Jun 26, 2019 Peer-reviewed

Books and Other Publications

マーモセットラボマニュアルはじめての取扱いから研究最前線まで

(Role: Joint author, 166-175)

アドスリー, Oct 31, 2018 (ISBN: 9784904419786)
こころの働きと病・覚醒剤－2007～2009世界脳週間の講演より－

(Role: Joint author, 125-142)

株式会社クバプロ, Mar 10, 2010 (ISBN: 9784878051074)
幹細胞・クローン研究プロトコール中辻憲夫編

(Role: Joint author, 231-239)

羊土社, Nov 1, 2001 (ISBN: 4897069351)

Presentations

Y染色体の存在がマウス雌性生殖系列に及ぼす影響

佐藤義治

第113回日本繁殖生物学会大会, Sep 23, 2020, 日本繁殖生物学会
マウス過剰排卵処置におけるPMSG投与時期の影響

外丸祐介

第67回日本実験動物学会総会（紙上開催、ポスター）, May 23, 2020, マウス過剰排卵処置におけるPMSG投与時期の影響外丸祐介、畠山照彦、神﨑道文第67回日本実験動物学会総会（紙上開催、ポスター）
Stepwise differentiation of ScxGFP iPS cells into mature tenocytes and ligamentocytes

Dec 3, 2019
マウス過剰排卵処置におけるPMSG投与のタイミングについて

外丸祐介

日本実験動物技術者協会関東支部REG部会第20回特別講演会, Nov 16, 2019, 日本実験動物技術者協会関東支部REG部
Effect of cetrorelix acetate administration on ovarian stimulation in aged mice.

Sotomaru Y

14th FELASA Congress, Jun 10, 2019, FELASA
ニホンザル体外受精卵のガラス化保存と冷蔵保存について

外丸祐介

Cryopreservation Conference 2018, Oct 25, 2018, Cryopreservation Conference
サル類における基盤的発生工学技術との凍結保存技術について

外丸祐介

第7回日本マーモセット研究会大会, Jan 16, 2018, 日本マーモセット研究会 Invited
サル類の体外培養系受精卵の作製について

外丸祐介

第35回動物生殖工学研究会（2017.12.2、川崎）（口頭）, Dec 2, 2017, 動物生殖工学研究会
A mutation of the spinocerebellar ataxia gene CACNA1G induces cerebellar Purkinje cell death and ataxia in mice.

Y. Matsuda

SFN2017, Nov 11, 2017
サル類における体外培養系受精卵の作製について．

外丸祐介

第51回日本実験動物技術者協会総会, Oct 13, 2017, 日本実験動物技術者協会総会 Invited
Parental origin-derived primary memories are erased in Zfp57-deficient embryonic stem cells.

Keisuke Sasaki

WCRB2017, Sep 28, 2017, 日本繁殖生物学会
Techniques for creating genetically identical animalsin the non-human primates.

Yusuke Sotomaru

2017 Asia-Oceania Regional Meeting for Marmoset Research, Mar 16, 2017 Invited
様々な核の組合せにより作製したマーモセット４倍体胚の発生能について

外丸祐介

第6回日本マーモセット研究会大会, Dec 12, 2016, 日本マーモセット研究会大会
Potineurin, a causative gene of amyotrophic lateral sclerosis, is involved in interferon beta production．

Fukushi M

第45回日本免疫学会学術集会, Dec 5, 2016, 日本免疫学会学術集会
霊長類における受精卵と精子の凍結保存

外丸祐介

Cryopreservation Conference 2016, Nov 10, 2016, 自然科学研究機構基礎生物学研究所 IBBPセンター
霊長類における遺伝的相同個体の作製技術について

外丸祐介

第63回日本実験動物学会総会, May 20, 2016, 日本実験動物学会 Invited
コモンマーモセットの膣スメアを指標にした性周期解析について

神田暁史

第5回日本マーモセット研究会大会, Jan 27, 2016, 日本マーモセット研究会大会
マーモセットにおける非侵襲的受精卵採取法を実施して

信清麻子

第5回日本マーモセット研究会大会, Jan 27, 2016, 日本マーモセット研究会大会
霊長類受精卵のガラス化保存

外丸祐介

Cryopreservation Conference 2015, Oct 28, 2015, 自然科学研究機構基礎生物学研究所 IBBPセンター
コモンマーモセット凍結保存精子の運動性と体外受精能

外丸祐介、畠山照彦、吉岡みゆき、信清麻子

第62回日本実験動物学会総会, May 29, 2015, 日本実験動物学会

Professional Memberships

Research Projects

胚盤胞補完法による臓器特異的疾患モデルマウスの開発

科学研究費助成事業基盤研究（Ｃ）, 文部科学省, Apr, 2018 - 2020

橋本晴夫
希少難治性疾患に対する画期的な医薬品医療機器等の実用化に関する研究：薬事承認を目指すシーズ探索研究（ステップ0）

日本医療研究開発機構研究費難治性疾患等実用化研究事業難治性疾患実用化研究事業, 国立研究開発法人日本医療研究開発機構, Mar, 2017 - 2019

吉子裕二
遺伝子改変マーモセットの効率的生産に向けた生殖工学技術の整備・開発

国家課題対応型研究開発推進事業（脳科学研究戦略推進プログラム・脳機能ネットワークの全容解明プロジェクト）, 日本医療研究開発機構, Apr, 2017 - Mar, 2018

外丸祐介
ウイルス感染は筋萎縮性側索硬化症(ALS)の発症に関与するか？

科学研究費助成事業基盤研究（Ｃ）, 文部科学省, 2016 - 2018

福士雅也
Role of polymeric OPN on fibrosis

KAKENHI, Grant-in-Aid for Scientific Research (C), MEXT, 2015 - 2018

Nishimichi Norihisa
Cancer fluid biopsy for childhood malignancies using one cell analysis

KAKENHI, Grant-in-Aid for Scientific Research (A), MEXT, 2015 - 2018

Hiyama Eiso, MASUJIMA TSUTOMU
遺伝子改変マーモセットの効率的生産に向けた生殖工学技術の整備・開発

脳科学研究戦略推進プログラム, 日本医療研究開発機構, Apr, 2016 - Mar, 2017

外丸祐介
遺伝子改変マーモセットの汎用性拡大および作出技術の高度化とその脳科学への応用

脳科学研究戦略推進プログラム, 日本医療研究開発機構, Apr, 2015 - Mar, 2016

外丸祐介
遺伝子改変マーモセットの汎用性拡大および作出技術の高度化とその脳科学への応用

国家課題対応型研究開発推進事業（脳科学研究戦略推進プログラム・脳機能ネットワークの全容解明プロジェクト）, 文部科学省, Apr, 2014 - Mar, 2015

外丸祐介
Comprehensive analysis of egg-specific reprograming factors based on cell cycle-specific localization

KAKENHI, Grant-in-Aid for Challenging Exploratory Research, MEXT, 2013 - 2015

SOTOMARU YUSUKE, KONO Tomohiro, KANDA Akifumi, HATAKEYAMA Teruhiko, YOSHIOKA Miyuki
生殖系列における性特異的エピゲノム制御の解明

科学研究費助成事業(基盤研究(A)), 基盤研究(A), 文部科学省, 2015

河野友宏, 外丸祐介
Detection of molecular targets for childhood cancers using genomics and cellomics: targeting for cancer stem cells

KAKENHI, Grant-in-Aid for Scientific Research (A), MEXT, 2012 - 2014

HIYAMA Eiso, KANAWA Masami, MASUJIMA Tsutomu, SOTOMARU Yusuke, KAMIMATSUSE Arata, OGURA Kaoru, NAKAGAWARA Akira
Analysis of Epigenome Marks and Transcriptome in the Germ Line by the Next Generation Sequencer

KAKENHI, Grant-in-Aid for Scientific Research (S), MEXT, 2010 - 2014

KONO Tomohiro, SOTOMARU Yusuke, SUZUKI Yutaka, KOBAYASHI Hisato
Establishment of the novel mouse model of metastatic colorectalcancer and identification of the biomarker for tissue-specific metastasis

KAKENHI, Grant-in-Aid for Scientific Research (B), MEXT, 2010 - 2013

HINOI, Takao
Molecular analysis for developing the newtargeting therapy in Japanese Pediatric Liver Tumor study group

KAKENHI, Grant-in-Aid for Scientific Research (B), MEXT, 2010 - 2012

KAMIMATSUSE, Arata, HIYAMA, Eiso, OGURA, Kaoru, KAMEI, Naomi, SOTOMARU, Yusuke
先端的遺伝子導入・改変技術による脳科学研究のための独創的霊長類モデルの開発と応用

国家課題対応型研究開発推進事業（キーテクノロジー研究開発の推進）脳科学研究戦略推進プログラム, 文部科学省, 2008 - 2012

伊佐正
Elucidation of development mechanism and molecular targets in neuroblastoma and hepatoblastoma using genomics and cellomics

KAKENHI, Grant-in-Aid for Scientific Research (B), MEXT, 2009 - 2011

HIYAMA, Eiso, MASUJIMA, Tsutomu, HIYAMA, Keiko, SOTOMARU, Yusuke, YAMAOKA, Hiroaki, KAMIMATSUSE, Arata
次世代シークエンサーを用いた生殖細胞におけるエピゲノム修飾の全ゲノムマッピング

科学研究費助成事業(基盤研究(A)), 基盤研究(A), 文部科学省, 2010 - 2010

河野友宏, 鈴木穣, 外丸祐介
神経芽腫のがん幹細胞研究:分化・退縮と発生・増殖・進展の二極化規定因子か?

科学研究費助成事業(基盤研究(B)), 基盤研究(B), 文部科学省, 2007 - 2008

檜山英三, 檜山桂子, 外丸祐介, 山岡裕明
Regulation of germ line function and development by genomic imprinting

KAKENHI, Grant-in-Aid for Scientific Research (A), MEXT, 2006 - 2008

KONO, Tomohiro, SOTOMARU, Yusuke