2018年12月10日
New tetrahydroquinoline and indoline compounds containing a hydroxy cyclopentenone, virantmycin B and C, produced by Streptomyces sp. AM-2504.
The Journal of antibiotics
- 巻
- 72
- 号
- 3
- 開始ページ
- 169
- 終了ページ
- 173
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41429-018-0117-0
- 出版者・発行元
- Nature Publishing Group
Two new antibiotics, designated virantmycin B (1) and C (2), were isolated from the cultured broth of Streptomyces sp. AM-2504. Compounds 1 and 2 were purified by Diaion HP-20, silica gel, and octadecylsilane chromatography, followed by high-performance liquid chromatography. The chemical structures of the new compounds, 1 and 2, were determined by nuclear magnetic resonance and mass spectrometry, as containing a terahydroquinoline and an indoline, respectively, each also containing a hydroxy cyclopentenone moiety. Both compounds demonstrated weak antimicrobial (both antibacterial and antifungal) activity and compound 1 also showed antiviral activity against the dengue virus, whereas compound 2 exhibited no antiviral properties.
- リンク情報
-
- DOI
- https://doi.org/10.1038/s41429-018-0117-0
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/30532036
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000459798500007&DestApp=WOS_CPL
- URL
- https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J04548&link_issn=&doc_id=20190225200007&doc_link_id=30532036&url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F30532036&type=PubMed&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00001_1.gif
- URL
- https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J04548&link_issn=&doc_id=20190225200007&doc_link_id=10.1038%2Fs41429-018-0117-0&url=https%3A%2F%2Fdoi.org%2F10.1038%2Fs41429-018-0117-0&type=Crossref&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00002_2.gif
- ID情報
-
- DOI : 10.1038/s41429-018-0117-0
- ISSN : 0021-8820
- eISSN : 1881-1469
- 医中誌Web ID : 2019287763
- ORCIDのPut Code : 57725579
- PubMed ID : 30532036
- Web of Science ID : WOS:000459798500007