2022年5月5日
Sattahipmycin, a Hexacyclic Xanthone Produced by a Marine-Derived Streptomyces.
Journal of natural products
- 巻
- 85
- 号
- 5
- 開始ページ
- 1211
- 終了ページ
- 1217
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.jnatprod.1c00870
Sattahipmycin was isolated from the mycelium of marine-derived Streptomyces sp. GKU 257-1 by following the antibiofilm activity against E. coli NBRC 3972 throughout the purification steps. The structure of sattahipmycin was determined to be a new polycyclic xanthone related to xantholipin but lacking a dioxymethylene and a chlorinated carbon. This compound showed activity toward Gram-positive bacteria and Plasmodium falciparum, antibiofilm formation of Escherichia coli, and cytotoxicity to human cancer cell lines. Using genome sequence data, a biosynthetic pathway leading to sattahipmycin has been proposed involving an uncharacterized type II polyketide synthase biosynthetic gene cluster.
- リンク情報
- ID情報
-
- DOI : 10.1021/acs.jnatprod.1c00870
- PubMed ID : 35512262