MISC

2009年6月

Survival and late effects on development of patients with infantile brain tumor

PEDIATRICS INTERNATIONAL
  • Yuko Nomura
  • ,
  • Sawa Yasumoto
  • ,
  • Fumio Yanai
  • ,
  • Hidetaka Akiyoshi
  • ,
  • Takahito Inoue
  • ,
  • Keiko Nibu
  • ,
  • Hitoshi Tsugu
  • ,
  • Takeo Fukushima
  • ,
  • Shinichi Hirose

51
3
開始ページ
337
終了ページ
341
記述言語
英語
掲載種別
DOI
10.1111/j.1442-200X.2008.02760.x
出版者・発行元
WILEY-BLACKWELL PUBLISHING, INC

Most infants with brain tumor may have a poor prognosis. The aim of the present study was to retrospectively analyze the survival and outcome with regard to mental and physical development in 11 subjects with brain tumor; these tumors were diagnosed when the patients were under 1 year of age.
The histological diagnoses of these tumors were astrocytoma, n > 3; pineocytoma, n > 2; teratoma, n > 1; ependymoma, n > 1; atypical teratoid/rhabdoid tumor, n > 1; glioblastoma, n > 1; medulloblastoma, n > 1; and choroid plexus papilloma, n > 1. Surgical resection was performed in eight patients, and adjuvant chemotherapy was administered to all except one patient with choroid plexus papilloma. Radiotherapy was additionally performed for four of the 10 chemotherapy patients.
Six patients survived. Among the surviving patients, five were under no treatment for 50-167 months after the diagnosis (median duration, 89 months), while one received chemotherapy for 20 months. Five patients exhibited mental retardation, and one patient experienced normal development after surgical removal of his choroid plexus papilloma. Diencephalic syndrome developed in one patient with pilomyxoid astrocytoma that necessitated hormone replacement therapy, and bodyweight over +2 SD was observed in two patients. The remaining five patients died 11-111 months after diagnosis (median duration, 24 months).
The prognosis of infantile brain tumor with regard to mortality and developmental outcome remains poor. Furthermore, survivors require comprehensive medical and social support for an extended period.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1111/j.1442-200X.2008.02760.x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19400825
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000266465700004&DestApp=WOS_CPL

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