2020年5月27日
Hypofractionated palliative volumetric modulated arc radiotherapy with the Radiation Oncology Study Group 8502 "qUAD shot" regimen for incurable head and neck cancer
Radiation Oncology
- 巻
- 15
- 号
- 1
- 開始ページ
- 123
- 終了ページ
- 123
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1186/s13014-020-01548-w
Background: To review a single institutional experience of the Radiation Therapy Oncology Group (RTOG) 8502 "QUAD shot" regimen using volumetric modulated arc radiotherapy (VMAT) for incurable head and neck cancer (HNC). Methods: Thirty-four consecutive patients with HNC were treated with at least one cycle of the RTOG 8502 regimen. Treatment plans included the use of VMAT with 6 MV photons generated by a linear accelerator. Two daily fractions of 3.7 Gy were delivered with an interval of at least 6 h for 2 consecutive days, totaling 14.8 Gy over 4 fractions. This was repeated every 3-4 weeks for a total of three cycles. No concurrent systemic therapy was performed. Results: The number of completed cycles was 1 in 6 (18%) patients, 2 in 5 (15%), and 3 in 23 (68%). Tumor response was achieved in 29 (85%) patients and symptom relief in 20 (77%) of 26 patients. Overall response (tumor response or symptom relief) was achieved in 32 (94%) patients. All patients who received 2 or more treatment cycles achieved overall response. Median overall survival (OS) was 5.7 months. Multivariate analysis revealed that completion of all three treatment cycles was significantly associated with better OS (P = 0.002). Grade 2 toxicity was observed in four (12%) patients, but no acute Grade ≥ 3 or late toxicity was observed. Conclusions: The RTOG 8502 "QUAD shot" regimen using VMAT is effective for incurable HNC with highly reduced toxicity. Treatment with multiple cycles is recommended for better treatment response and/or survival.
- リンク情報
-
- DOI
- https://doi.org/10.1186/s13014-020-01548-w
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/32460865
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251877
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085589418&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85085589418&origin=inward
- ID情報
-
- DOI : 10.1186/s13014-020-01548-w
- eISSN : 1748-717X
- PubMed ID : 32460865
- PubMed Central 記事ID : PMC7251877
- SCOPUS ID : 85085589418