MASUMURA Kenichi

J-GLOBAL         Last updated: Mar 16, 2018 at 12:56
 
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Name
MASUMURA Kenichi
Affiliation
National Institute of Health Sciences
Section
Division of Genetics and Mutagenesis
Job title
Researcher
Degree
PhD

Research Areas

 
 

Academic & Professional Experience

 
Oct 2012
 - 
Today
Section Chief, Division of Genetics and Mutagenesis, National Institute of Health Sciences
 
1996
   
 
- Researcher, National Institute of Health Sciences
 

Published Papers

 
You X, Ando T, Xi J, Cao Y, Liu W, Zhang X, Honma M, Masumura K, Luan Y
Mutagenesis      Feb 2018   [Refereed]
Masumura K, Toyoda-Hokaiwado N, Niimi N, Grúz P, Wada NA, Takeiri A, Jishage KI, Mishima M, Nohmi T
Environmental and molecular mutagenesis   58(9) 644-653   Dec 2017   [Refereed]
Nohmi T, Masumura K, Toyoda-Hokaiwado N
Genes and environment : the official journal of the Japanese Environmental Mutagen Society   39 11   Feb 2017   [Refereed]
Masumura K, Toyoda-Hokaiwado N, Ukai A, Gondo Y, Honma M, Nohmi T
Mutation research   810 30-39   Nov 2016   [Refereed]
Morita T, Hamada S, Masumura K, Wakata A, Maniwa J, Takasawa H, Yasunaga K, Hashizume T, Honma M
Mutation research. Genetic toxicology and environmental mutagenesis   802 1-29   May 2016   [Refereed]
Masumura K, Toyoda-Hokaiwado N, Ukai A, Gondo Y, Honma M, Nohmi T
Genes and environment : the official journal of the Japanese Environmental Mutagen Society   38 10   Apr 2016   [Refereed]
Masumura K, Sakamoto Y, Kumita W, Honma M, Nishikawa A, Nohmi T
Genes and environment : the official journal of the Japanese Environmental Mutagen Society   37 24   Dec 2015   [Refereed]
Kuroda K, Hibi D, Ishii Y, Yokoo Y, Takasu S, Kijima A, Matsushita K, Masumura K, Kodama Y, Yanai T, Sakai H, Nohmi T, Ogawa K, Umemura T
Toxicological sciences : an official journal of the Society of Toxicology   144(1) 65-76   Mar 2015   [Refereed]
Yasunobu Aoki, Akiko H. Hashimoto, Yoshiki Sugawara, Kyoko Hiyoshi-Arai, Sataro Goto, Kenichi Masumura, Takehiko Nohmi
Genes and Environment   37    Jan 2015
© 2015 Aoki et al. Introduction: To examine whether the mutagenic potential of lung exposure to air-borne environmental mutagens is age dependent, we administered 1 mg of benzo[a]pyrene intratracheally to 11- And 24-month old (middle-aged and old,...
Takeiri A, Wada NA, Motoyama S, Matsuzaki K, Tateishi H, Matsumoto K, Niimi N, Sassa A, Grúz P, Masumura K, Yamada M, Mishima M, Jishage K, Nohmi T
DNA repair   24 113-121   Dec 2014   [Refereed]
Kawamura Y, Hayashi H, Masumura K, Numazawa S, Nohmi T
Toxicology   324 10-17   Oct 2014   [Refereed]
Kuroda K, Hibi D, Ishii Y, Takasu S, Kijima A, Matsushita K, Masumura K, Watanabe M, Sugita-Konishi Y, Sakai H, Yanai T, Nohmi T, Ogawa K, Umemura T
Mutagenesis   29(1) 27-36   Jan 2014   [Refereed]
Horibata K, Ukai A, Kimoto T, Suzuki T, Kamoshita N, Masumura K, Nohmi T, Honma M
Environmental and molecular mutagenesis   54(9) 747-754   Dec 2013   [Refereed]
Kawamura Y, Hayashi H, Kurata Y, Hiratsuka K, Masumura K, Nohmi T
Toxicology   312 56-62   Oct 2013   [Refereed]
Takehiko Nohmi, Takehiko Nohmi, Masami Yamada, Kenichi Masumura
Genes and Environment   34(4) 146-152   Dec 2012   [Refereed]
In regulatory toxicology, it is assumed that genotoxic carcinogens, which induce cancer through genotoxic mechanisms, have no threshold for their action. However, humans possess a number of defense mechanisms against DNA damaging agents, which may...
Takehiko Nohmi, Masamitsu Honma, Masami Yamada, Kenichi Masumura, Manabu Yasui, Katsuyoshi Horibata, Shoji Fukushima
Genes and Environment   34(4) 141-145   Dec 2012   [Refereed]
Tomoyuki Kamigaito, Tadashi Noguchi, Kazunori Narumi, Rie Takashima, Shuichi Hamada, Hisakazu Sanada, Masayuki Hasuko, Hiroyuki Hayashi, Kenichi Masumura, Takehiko Nohmi
Genes and Environment   34(1) 34-44   May 2012   [Refereed]
This study was conducted to evaluate the effectiveness of a transgenic rat mutation assay using F344 gpt delta rats. We investigated the mutagenic potential in the lung of nickel subsulfide (Ni3S2), an insoluble fine-crystallinemetallic compound a...
Yuji Kawamura, Hiroyuki Hayashi, Osamu Tajima, Sayuri Yamada, Tomomi Takayanagi, Hisako Hori, Wataru Fujii, Kenichi Masumura, Takehiko Nohmi
Genes and Environment   34(1) 18-24   May 2012   [Refereed]
Transgenic rat gene-mutation assays can be used to assess genotoxicity of chemicals in target organs for carcinogenicity. Since gene mutations in transgenes are genetically neutral and thus accumulate along with treatment periods, the assays are s...
Hajime Sui, Ryo Ohta, Toshiyuki Shiragiku, Ayaka Akahori, Kenichiro Suzuki, Madoka Nakajima, Hiroyuki Hayashi, Kenichi Masumura, Takehiko Nohmi
Genes and Environment   34(1) 25-33   May 2012   [Refereed]
The transgenic rodent (TGR) assay has been widely used to study in vivo gene mutations by chemicals or radiation; however, an optimal protocol has not yet been established to assess unknown genotoxic potential. The International Workshop on Genoto...
Naomi Toyoda-Hokaiwado, Yumiko Yasui, Yumiko Yasui, Makiko Takamune, Masami Yamada, Mina Muramatsu, Mina Muramatsu, Kenichi Masumura, Toshihiro Ohta, Takuji Tanaka, Takuji Tanaka, Takehiko Nohmi, Takehiko Nohmi
Genes and Environment   33(4) 160-166   Dec 2011   [Refereed]
Capsaicin from the red chili pepper is a prospective chemopreventive agent. To explore the possible antigenotoxic effects of capsaicin on N-diethylnitrosamine (DEN)- induced mutagenesis in vitro , we conducted bacterial mutation assays with Salmon...
Toyoda-Hokaiwado N, Yasui Y, Muramatsu M, Masumura K, Takamune M, Yamada M, Ohta T, Tanaka T, Nohmi T
Carcinogenesis   32(10) 1512-1517   Oct 2011   [Refereed]
Yamamoto A, Sakamoto Y, Masumura K, Honma M, Nohmi T
Mutation research   713(1-2) 56-63   Aug 2011   [Refereed]
Koyama N, Yasui M, Kimura A, Takami S, Suzuki T, Masumura K, Nohmi T, Masuda S, Kinae N, Matsuda T, Imai T, Honma M
Mutagenesis   26(4) 545-549   Jul 2011   [Refereed]
Masumura K, Sakamoto Y, Ikeda M, Asami Y, Tsukamoto T, Ikehata H, Kuroiwa Y, Umemura T, Nishikawa A, Tatematsu M, Ono T, Nohmi T
Environmental and molecular mutagenesis   52(3) 244-252   Apr 2011   [Refereed]
Facciotti MT, Pang WL, Lo FY, Whitehead K, Koide T, Masumura K, Pan M, Kaur A, Larsen DJ, Reiss DJ, Hoang L, Kalisiak E, Northen T, Trauger SA, Siuzdak G, Baliga NS
BMC systems biology   4 64   May 2010   [Refereed]
Okudaira N, Uehara Y, Fujikawa K, Kagawa N, Ootsuyama A, Norimura T, Saeki K, Nohmi T, Masumura K, Matsumoto T, Oghiso Y, Tanaka K, Ichinohe K, Nakamura S, Tanaka S, Ono T
Radiation research   173(2) 138-147   Feb 2010   [Refereed]
Whitehead K, Pan M, Masumura K, Bonneau R, Baliga NS
PloS one   4(5) e5485   2009   [Refereed]
Kuroiwa Y, Yamada M, Matsui K, Okamura T, Ishii Y, Masumura K, Tasaki M, Umemura T, Mitsumori K, Nohmi T, Hirose M, Nishikawa A
Toxicological sciences : an official journal of the Society of Toxicology   104(2) 274-282   Aug 2008   [Refereed]
Yamauchi K, Kakinuma S, Sudo S, Kito S, Ohta Y, Nohmi T, Masumura K, Nishimura M, Shimada Y
Mutation research   640(1-2) 27-37   Apr 2008   [Refereed]
Hashimoto AH, Amanuma K, Hiyoshi K, Sugawara Y, Goto S, Yanagisawa R, Takano H, Masumura K, Nohmi T, Aoki Y
Environmental and molecular mutagenesis   48(8) 682-693   Oct 2007   [Refereed]
Aoki Y, Hashimoto AH, Amanuma K, Matsumoto M, Hiyoshi K, Takano H, Masumura K, Itoh K, Nohmi T, Yamamoto M
Cancer research   67(12) 5643-5648   Jun 2007   [Refereed]
Xu A, Smilenov LB, He P, Masumura K, Nohmi T, Yu Z, Hei TK
Environmental health perspectives   115(1) 87-92   Jan 2007   [Refereed]
Kuroiwa Y, Umemura T, Nishikawa A, Kanki K, Ishii Y, Kodama Y, Masumura K, Nohmi T, Hirose M
Archives of toxicology   81(1) 63-69   Jan 2007   [Refereed]
Jiang L, Zhong Y, Akatsuka S, Liu YT, Dutta KK, Lee WH, Onuki J, Masumura K, Nohmi T, Toyokuni S
Cancer science   97(11) 1159-1167   Nov 2006   [Refereed]
Takeiri A, Mishima M, Tanaka K, Shioda A, Harada A, Watanabe K, Masumura K, Nohmi T
Mutation research   609(1) 102-115   Oct 2006   [Refereed]
Hashimoto AH, Amanuma K, Hiyoshi K, Takano H, Masumura K, Nohmi T, Aoki Y
Environmental and molecular mutagenesis   47(4) 277-283   May 2006   [Refereed]
Sato Y, Takahashi S, Kinouchi Y, Shiraki M, Endo K, Matsumura Y, Kakuta Y, Tosa M, Motida A, Abe H, Imai G, Yokoyama H, Nomura E, Negoro K, Takagi S, Aihara H, Masumura K, Nohmi T, Shimosegawa T
Carcinogenesis   27(5) 1068-1073   May 2006   [Refereed]
Miyazaki M, Yamazaki H, Takeuchi H, Saoo K, Yokohira M, Masumura K, Nohmi T, Funae Y, Imaida K, Kamataki T
Carcinogenesis   26(11) 1947-1955   Nov 2005   [Refereed]
Totsuka Y, Nishigaki R, Enomoto S, Takamura-Enya T, Masumura K, Nohmi T, Kawahara N, Sugimura T, Wakabayashi K
Chemical research in toxicology   18(10) 1553-1562   Oct 2005   [Refereed]
Hashimoto AH, Amanuma K, Hiyoshi K, Takano H, Masumura K, Nohmi T, Aoki Y
Environmental and molecular mutagenesis   45(4) 365-373   May 2005   [Refereed]
Shibata A, Kamada N, Masumura K, Nohmi T, Kobayashi S, Teraoka H, Nakagama H, Sugimura T, Suzuki H, Masutani M
Oncogene   24(8) 1328-1337   Feb 2005   [Refereed]
Shibata A, Masutani M, Kamada N, Masumura K, Nakagama H, Kobayashi S, Teraoka H, Suzuki H, Nohmi T
Environmental and molecular mutagenesis   43(3) 204-207   2004   [Refereed]
Furuno-Fukushi I, Masumura K, Furuse T, Noda Y, Takahagi M, Saito T, Hoki Y, Suzuki H, Wynshaw-Boris A, Nohmi T, Tatsumi K
Radiation research   160(5) 549-558   Nov 2003   [Refereed]
Takeiri A, Mishima M, Tanaka K, Shioda A, Ueda O, Suzuki H, Inoue M, Masumura K, Nohmi T
Chemical research in toxicology   16(2) 171-179   Feb 2003   [Refereed]
Mutation induction by heavy ion irradiation of gpt delta transgenic mice.
Yatagai F, Nohmi T, Kusakabe M, Masumura K, Yoshiki A, Yamaguchi H, Kurobe T, Kuniya K, Hanaoka F, Yano Y
Uchu Seibutsu Kagaku   14(3) 172-173   Oct 2000   [Refereed]

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 2010 - 2013    Investigator(s): Takehiko NOHMI
In regulatory toxicology, it is an axiom that there is no threshold for the action of genotoxic chemicals. Thus, genotoxic agents are not allowed to be present in food additives and others even at very low concentrations. However, humans possess v...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 2006 - 2009    Investigator(s): Takehiko NOUMI
DNA polymerase kappa (Polκ) is an enzyme involved in DNA synthesis across DNA lesions (translesion DNA synthesis). We identified important amino acids involved in the translesion DNA synthesis and generated human cells and mice, whose Polκ activit...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2004 - 2005    Investigator(s): Dai NAKAE
The present study assessed possible involvement of gene mutation in the early stage hepatocarcinogenesis, using gpt delta rats with a reporter transgene. In the study, 6-week-old male gpt delta rats originated from either Fischer 344 (F344) or Spr...
in vivo mutagenicity test of environmental mutagens using transgenic rodent mutation assay